When Appelbaum was a medical student, he happened upon an early write-up of bone-marrow transplantation by Dr. E. Donnall Thomas, who later won a Nobel Prize for the pioneering blood-cancer treatment. Little did he know that one day he'd have Thomas' job at the Hutchinson Center.
Through years of intensive research, Buck became the first to identify a family of genes that control the olfactory system, a complex network that governs our sense of smell.
Co-Director, UCI/Hutchinson Center Cancer Alliance
Early in his career, Dr. Corey Casper developed a staggering vision. He knew that more than 20 percent of cancer cases are triggered by infectious disease. And he believed that these cancers could be prevented or eliminated in a relatively short amount of time.
Just as the Center's founders showed the world that blood cancers could be conquered, Cheever is working to create one of the nation's leading programs devoted to developing breakthrough treatments for breast, prostate, colorectal and other solid tumor cancers.
By harnessing the healing power of umbilical cord blood, Delaney is on the forefront of developing a treatment that may prove to be a landmark breakthrough for deperately ill leukemia patients.
Longtime collaboration between Malik and Emerman has led to important discoveries about the evolutionary struggle between viruses and humans. Ultimately, they hope their research may lead to new drugs to fight HIV.
By turning to tiny yeast cells for clues, Gottschling is trying to get a better grasp on a problem that has long vexed biologists: the relationship between cancer and aging.
Greenberg is a world expert in discovering how rare disease-fighting cells, called T-cells, can be manipulated to treat a range of cancers—and with milder side effects than traditional therapies.
Groudine says he's "not at all a top down kind of leader—I give people responsibility and turn them loose." Meanwhile, his own research as an award-winning molecular and cellular biologist has earned him international renown.
Renowned for his genetic research, Henikoff has developed widely used computer programs and a wealth of other research tools that have led to breakthroughs in many areas of basic science.
Higano is a pioneer in testing therapeutic vaccines against prostate cancer—part of a growing field of cancer research called immunotherapy, which harnesses the natural power of the immune system to fight disease.
Hingorani's work has yielded one of the most significant advances in decades related to early detection and treatment of pancreas cancer, a disease that is almost uniformly a death sentence by the time it is detected.
Kiem investigates how stem cells can be extracted, manipulated at a genetic level and delivered back to sick patients to treat a range of diseases, from infections like HIV to aggressive cancers.
Maloney has played a pivotal role in developing targeted treatments that rely on special molecules called antibodies to fight cancer, including a paradigm-changing drug for lymphoma patients.
A veteran leukemia researcher and oncologist, Martin is devoted to improving the lives of patients who have received bone marrow or stem cell transplants.
As one of the leaders of a massive international effort to develop a preventive vaccine for HIV, McElrath has spent more than two decades at the forefront of the war on AIDS.
McTiernan's groundbreaking studies have produced some of the first specific answers about the role of exercise and weight loss in reducing cancer risk, earning her a spot on a federal advisory committee.
Mostaghel works to improve our understanding of what makes cancer treatments successful and how best to target them to patients, with a focus on prostate cancer.
Nelson's pioneering work on the mother-child cell transfer that happens during pregnancy, known as microchimerism, could form the basis for new therapies for people with autoimmune diseases like rheumatoid arthritis, scleroderma and diabetes.
Employing a cutting-edge technology called RNA interference, Paddison investigates why cells behave in particular ways--work that could lead to better therapies for many diseases.
Paulovich's lab develops technologies aimed at rapidly screening large numbers of telltale proteins—known as "biomarkers"—for clues that may indicate the earliest stages of cancer and other diseases.
By examining the evolution of body type and behavior in stickleback fish, Peichel works to shed light on the genetic networks at play in other complex traits, such as cancer and other common human diseases.
Some of the world's most successful treatments for lymphoma and other blood cancers have emerged from research by Press and colleagues, who pioneered the use of radioactive molecules that blast cancer with high doses of radiation while sparing healthy cells.
Physician, cancer researcher, and health economist
When Ramsey talks about medicine, his upturned palms often rise to form an imaginary scale. As a physician, cancer researcher and health economist, he weighs the cost and benefit of various treatments, doggedly advocating for the best patient care for the least amount of money.
Growing up in an orphanage in Hershey, Pa., Roth often heard "no" from the adults in his life. No, he couldn't run on the high-school track or cross-country teams. No, he'd never be a scientist. Now his research may one day transform emergency medicine.
Why are some cancer cells so successful at dodging our body's natural disease-fighting powers? That's the major research question that motivates Spies and his colleagues, whose work may lead to new approaches for cancer treatment.
The hope of cancer prevention motivates Stanford on a very personal level. Five of her close family members have fought the disease. "I look at my son," she says, "and I am inspired to do something to prevent him from getting prostate cancer like both of his grandfathers."
In his laboratory at the Hutchinson Center, Dr. Barry Stoddard uses some of the most advanced technology in the world to probe the structure and function of biological molecules atom by atom.
Much of what scientists have learned—and are still learning—about the biology of stem-cell transplantation came from Storb's laboratory. He continues to pioneer new blood-cancer treatments after working on team led by Dr. E. Donnall Thomas, the father of bone marrow transplantation.
Taniguchi delves into a natural process called DNA repair to shed light on a phenomenon that has long vexed oncologists: why anti-cancer drugs often decline in effectiveness over time.
By studying molecules called micro-RNAs in our cells, Tewari hopes to better understand what makes unchecked cell growth occur, particularly with cancerous ovarian and prostate tumors. His work holds promise for improving early detection and treatment of cancers.
Through refining a technique called adoptive T-cell therapy, Warren is working to develop treatments that use the body's immune system to attack kidney and colon cancers more precisely while sparing healthy organs.
Yee is on the cutting edge of a medical field called adoptive immunotherapy, which he has used to fight advanced skin cancer by harnessing a patient's own infection-fighting T-cells to seek and destroy tumor cells.
The Hutchinson Center's clinical research breakthroughs are delivered to patients through our treatment arm, the Seattle Cancer Care Alliance. This collaboration combines the strengths of the Hutchinson Center, UW Medicine and Seattle Children's.
You can help eliminate cancer and related diseases by attending Hutchinson Center events and participating in our other fundraising and community efforts.
The Hutchinson Center's pioneering researchers push the boundaries of science to find new ways to prevent, detect and treat cancer and related diseases.