Symposium Schedule

Seattle Genetic Instability and Cancer Symposium

April 22, 2013

9am-7pm in Pelton Auditorium

9:00-9:15         Welcome

9:15-10:30       Session 1: Replication Stress and DNA Damage Response

Bridget Hughes—An essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation (Postdoc, Clurman lab, FHCRC)

Nicholas Wallace—Beta Human Papillomavirus 5 and 8 E6 Expression Disrupts BRCA1-Mediated Double Strand Break repair (Postdoc, Galloway lab, FHCRC)

Laura Lee—The role of chromatin remodelers in the S phase checkpoint (Graduate Student, Tsukiyama lab, FHCRC)

Jairo Rodriguez—ATR-like kinase Mec1 up-regulates chromatin accessibility at DNA replication forks and facilitates replication fork progression during replication stress (Postdoc, Tsukiyama lab, FHCRC)

Masaoki Kawasumi—A chemical genetic screen identifies novel ATM/ATR pathway inhibitors that sensitize p53-deficient cells to DNA-damaging agents without affecting ATR kinase catalytic activity (Acting Instructor, Nghiem Lab, UW)

10:30-10:50     Coffee Break

10:50-12:05     Session 2: DNA Repair and Mutagenesis

Philamer Calses—UV-induced phosphorylation of DGCR8 regulates cellular resistance to UV (Graduate Student, Taniguchi Lab, FHCRC)

Jen-Wei Huang—miR-103/107 target RAD51 and RAD51D to promote cellular sensitivity to cisplatin and PARP inhibition (Graduate Student, Taniguchi Lab, FHCRC)

Julia Sidorova—Novel methods in the analysis of DNA replication and DNA damage response in human cells (Research Assistant Professor, UW)

Alan Herr—DNA replication error-induced extinction of diploid yeast (Principal Investigator, UW)

Edward Fox—Lethal Mutagenesis: targeting the mutator phenotype in cancer

(Acting Assistant Professor, Loeb Lab, UW)

12:05 – 1:30    Lunch

1:30 – 3:00      Session 3: Cancer Mechanisms

Celia Payen—Mechanism of formation of large inverted duplications (Postdoc, Dunham Lab, UW)

Anna Sunshine—Defining the genetic basis of aneuploidy’s effect on cellular fitness (Graduate Student, Dunham Lab, UW)

Andrew Adey—The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line (Graduate Student, Shendure Lab, UW)

Sarah Zanders—It ain't just fair: cheating chromosome segregation in meiosis and mitosis (Postdoc, Malik and Smith Labs, FHCRC)

Kyle Fowler—Three-dimensional Control of Meiotic Recombination Initiation (Research Technician, Smith Lab, FHCRC)

Yu Ding—Cancer-specific requirement for BUB1B/BUBR1 in human brain tumor initiating cells and genetically transformed cells (Postdoc, Paddison Lab, FHCRC)

3:00 – 3:20      Coffee Break (Poster Set-up)

3:20 – 4:10      Keynote Address, Dr. Junjie Chen, Protein-protein interaction network in                                    DNA damage response and tumorigenesis                                                                                                       (University of Texas MD Anderson Cancer Center)

4:10 – 5:10      Session 4: Genetic Engineering

Ryo Takeuchi—Creation of Endonucleases Targeting Human Genes for Genome Engineering (Staff Scientist, Stoddard Lab, FHCRC)

Blake Hovde—Targeting DNA methylation using homing endonuclease/ methyltransferase fusion proteins (Graduate Student, Monnat Lab, UW)

Sandrine Boissel—MegaTALs: a novel designer rare-cleaving nuclease scaffold for highly active and specific genome engineering (Graduate Student, Scharenberg Lab, Seattle Children’s)

Martine Aubert—Prevention of HSV pathogenesis by rare-cutting DNA endonuclease mediated mutagenesis of latent viral genomes (Senior Staff Scientist, Jerome Lab, FHCRC)

5:10 – 5:15      Closing Remarks

5:15 –5:30       Poster Set-up

5:30 –7:00       Reception and Poster Session (SZE/ D1-080 combo room)                                                       Registration required

REGISTRATION

Register for SGICS is now closed. Registration is required to attend the Reception and Poster session. The symposium talks are open to the public and do not require registration.