"CMV-specific immunity after cord blood transplantation and studies on the persistence of T cell memory"
Human cytomegalovirus (HCMV) infects approximately 60% of the US population and is a significant pathogen in newborns, HIV infected individuals and after transplantation. Immune reconstitution to CMV after hematopoietic cell transplantation (HCT) is important for long-term protection from CMV infection and disease. This project will address two aspects of CMV T cell immunology: first, reconstitution of CMV-specific T cell immunity after cord blood transplantation in seropositive recipients, and second, immune reconstitution after primary CMV infection via stem cells. Studies will provide important novel insight into the biology of T cell responses and memory in two distinct clinical settings.