Human Biology Division

Image: Human Biology laboratory

Integrating fundamental, applied and translational scientists to improve the diagnosis, treatment and prevention of cancer and other diseases.

Human Biology researchers come together to form a multidisciplinary team that is influenced by individual advances. Their diverse expertise include molecular and cell biology, genomics, genetics, virology, infectious disease, computational biology, pathology and clinical research. Grounded in high-quality basic science, the research performed in Human Biology blends fundamental, applied, and translational research performed in model organisms and in vitro systems.

Highlights

Highlight 1
Hutch Integrated Data Repository and Archive (HIDRA) database aims to change how cancer is treated as doctors will be able to tailor treatment to patients by seeing what has worked for others with similar tumors
Read more about HIDRA »
Highlight 2
The tumor suppressor p53 regulates key events in the cellular lifecycle, including cell cycling, cell death, and senescence. Disruption of p53 in model systems leads to increased frequency and earlier development of cancer.
Read more about microRNA control of p53 »
Highlight 3
Together Fred Hutch, UW Medicine and SCCA are working to develop the most precise treatment options for patients with solid tumor cancers. The primary goal is to translate laboratory sciences into the most precise treatment options for patients with solid tumor cancers.
Learn more about STTR »
Highlight 4
On April 18, 2014, fifteen students from the Edmonds Community College Mathematics, Engineering, and Science Achievement (MESA) students visited the FHCRC to meet scientists, learn about their science and visit laboratories. This was a two hour event organized by Hutch United.
Read more about the MESA visit »
Highlight 5
If treated early, prostate cancer is usually curable. After metastasis occurs, however, these tumors become resistant to treatment and are generally fatal. Therefore, inhibiting metastasis may significantly improve the survival time for patients with prostate cancer. The Vasioukhin laboratory has previously shown that the host serine protease Hepsin promotes prostate cancer progression and metastasis.
Read more about hepsin inhibitors and metastasis »
Highlight 6
Hemizygous deletions at chromosomal location 16q22.1 frequently occur in many human cancers, including more than 50% of all breast cancers. One of the genes in this locus, CTCF, is critical for chromatin organization and acts as a master regulator of the genome.
Read more about CTCF »
Highlight 7
Dr. Chris Kemp of the Human Biology Division at Fred Hutch, co-authored a paper demonstrating that, in contrast to the predominant “two hit” theory on tumor suppressor genes, it was not necessary to lose both copies, one hit was enough.
Read more about tumor suppressor gene research  »
Highlight 8
Dr. Stephen Tapscott has labored for years at Fred Hutchinson Cancer Research Center to unravel the mechanisms that drive muscular dystrophy, a condition that steadily deteriorates muscles until they stop functioning. Last year that work caught the attention of a key partner that could be critical to transforming Tapscott's research into an effective therapy.
Read more about partnering to beat muscular dystrophy »
Highlight 9
Resistance to chemotherapy is almost as frustrating for oncologists as it is heartbreaking for cancer patients. Thanks to a breakthrough by a team of scientists led by Dr. Pete Nelson, science is a significant step closer to understanding why chemotherapy fails to wipe out all of the tumor cells it targets.
Read improving chemotherapy »
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Faculty & Labs

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Fred Hutchinson Cancer Research Center is a world leader in research to prevent, detect and treat cancer and other life-threatening diseases.