Human Biology Division

About the Division

The Human Biology Division was formed in 1998 by merging the Cancer Biology Program, the Division of Molecular Medicine, and an initiative in genetics/genomics. Since that time, Human Biology has stimulated productive interactions that transcend these programs. The goal of Human Biology is to cultivate interdisciplinary research focused on human biology and the complex problems of cancer and other human diseases. The program is structured to foster and support laboratory-based and computational research at the interface of basic, clinical, and population sciences.

Human Biology faculty members are unified by their common focus on problems of human biology, despite the challenges presented by the genetic and lifestyle factors that influence disease risk. Faculty also share a conviction that multidisciplinary approaches are essential to achieve better understanding, diagnosis, treatment, and  prevention of human disease. Therefore, the program blends fundamental, applied, and translational research. While research in the program is solidly grounded in high-quality basic research into molecular mechanisms, often performed in model organisms and in vitro systems, Human Biology faculty derive key insights from clinical and population-based research.

The Human Biology Division brings together faculty with expertise in molecular and cell biology, genomics, genetics, virology, infectious disease, computational biology, pathology and clinical research. In other institutions, such a diverse faculty would be distributed among many different departments. In Human Biology, the close interaction of this broad collection of talented and motivated investigators provides unique opportunities for synergistic collaborations. The division is comprised of 23 faculty members who are training 90 postdoctoral fellows and graduate students. Each faculty member is independent, and the division follows an egalitarian style of governance and support.

The division plans a major expansion in solid tumor research over the next five years, with the recruitment of a new division director and another seven faculty members. The Center has traditionally been world famous for its research and treatment of hematologic malignancies.  The association of Fred Hutchinson Cancer Research Center with Seattle Cancer Care Alliance (SCCA) has tremendously expanded the care of patients with solid tumors. The Human Biology Division is committed to increase the ongoing research on solid tumor cancer biology that is being done in this division and the Clinical Research Division, as well as the excellent population-based research on solid tumors done in the Public Health Sciences Division.

Multidisciplinary research is encouraged within the division through inter-laboratory communication and collaboration. Interactions across divisional lines are enhanced by the fact that many Human Biology faculty members hold joint appointments in the Basic Sciences, Clinical Research, or Public Health Sciences divisions and are affiliated with various University of Washington departments

The division's laboratories occupy all three floors of the Hutchinson Building and parts of the adjacent Thomas Building on the Robert W. Day Campus at South Lake Union. Sky bridges connect the labs of the division with other divisions at the Hutchinson Center. In addition, graduate students and postdoctoral fellows provide an important link among faculty in the five divisions and receive support through interdisciplinary training grants. Extensive Shared Resources at the Hutchinson Center help division labs access cutting-edge technologies.

Major areas of research in the Human Biology Division include: the biology of cell proliferation, DNA repair, apoptosis, cellular immortality, and differentiation; evolution and genetics, including genomic studies of the aberrations associated with cancer progression and resistance to chemotherapy; the biology of human pathogens, including H. pylori, HIV, HPV and CMV; mouse models of human cancer and other human disorders; discovery of new biomarkers for early detection of disease; and the development of new therapies for cancer, AIDS, and other human diseases. Investigators in the Human Biology Division also interact closely with population-based scientists and clinicians studying the genetics and epidemiology of breast, cervical, ovarian, prostate, and esophageal cancers to find better ways to prevent, diagnose, and treat these cancers.

For more information on interests of individual faculty in the Human Biology Division, see Faculty Research.

Fred Hutchinson Cancer Research Center is a world leader in research to prevent, detect and treat cancer and other life-threatening diseases.