Human Biology Division

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Assistant Member, Human Biology Division
The Beronja Lab studies molecular and cellular mechanisms that are essential for tissue growth during development and tumorigenesis. Our goal is to identify genes and gene pathways that can be used as targets in cancer therapy with a particular focus on the regulators of the balance between stem cell renewal and differentiation.
Phone: (206) 667-7609
Fax: (206) 667-2917
Associate Member, Human Biology Division
The Bielas Laboratory studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the pathogenesis of cancer and age-related disease.
Phone: (206) 667-3170
Fax: (206) 667-2537
Research Member, Human Biology Division
The Bolouri lab is interested in understanding how gene regulatory interactions control cellular state and identity, both in normal development (e.g. in stem cell differentiation) and in diseases such as cancer. A particular focus of the lab is the development and use of integrative computational systems biology methods to map gene regulatory networks from whole genome data (sequence, expression, DNA methylation, miRNA-seq, etc).
Phone: (206) 667-2748
Fax: (206) 667-2917
Professor, Department of Medicine, University of Washington
Jose Carreras/E. Donnall Thomas Endowed Chair for Cancer Research, Fred Hutchinson Cancer Research Center
The Clurman Lab studies how cell division is regulated in normal cells, and how abnormal control of cell division leads to cancer. They hope to use these mechanistic insights into tumor formation to develop new cancer treatment strategies.
Phone: (206) 667-4524
Fax: (206) 667-5255
Affiliate Investigator, Human Biology Division
Genomic duplication followed by adaptive mutation is considered one of the primary forces for evolution of new function. Duplicated sequences are also dynamic regions of rapid structural change during the course of chromosome evolution. The long-term goal of his research is to understand the evolution, pathology and mechanism(s) of recent gene duplication and DNA transposition within the human genome. His work involves the systematic discovery of these regions, the development of methods to assess their variation, the detection of signatures of rapid gene evolution and ultimately the correlation of this genetic variation with phenotypic differences within and between species.
Phone: (206) 543-9526
Fax: (206) 543-6575
Director of Molecular and Cellular Biology (MCB) Graduate Program, Fred Hutchinson Cancer Research Center
Editor-in-Chief (as of Jan. 1, 2013), Virology
Associate Editor, PLoS Pathogens
The Emerman Lab studies the molecular and evolutionary basis for the replication of HIV and related viruses, with an emphasis on the interaction of these viruses with their host cells. Our goal is to understand what determines resistance or vulnerability to current, past and potential viral diseases.
Phone: (206) 667-5058
Fax: (206) 667-6523
The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.
Phone: (206) 667-4500
Fax: (206) 667-5815
Attending Physician, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses
Phone: (206) 667-5122
Fax: (206) 667-6523
Research Associate Member, Human Biology Division
The Grandori Lab focuses on exploiting the weaknesses of cancer cells to identify targeted, less toxic cancer therapies. RNA interference (RNAi) combined with high throughput technology enables us to interrogate the human genome for genes that are essential for viability of molecularly defined cancer cells, thus allowing the unbiased identification of these Achilles' heels.
Phone: (206) 667-1835
Fax: (206) 667-5815
The Hockenbery lab studies programmed cell death (apoptosis) pathways that are defective in many cancer cells; and the role of cancer-cell metabolism in apoptosis, oncogene functions, and environmental/dietary risk factors, including excess supply of nutrients. After identifying cancer-selective targets, they carry out small-molecule screens for inhibitors to identify lead compounds as anticancer agents.
Phone: (206) 667-4611
Fax: (206) 667-6519
Senior VP and Director , Human Biology Division
Director, Solid Tumor Translational Research, Fred Hutchinson Cancer Research Center and UW Medicine
Chap and Eve Alvord and Elias Alvord Chair in Neuro-Oncology, UW Medicine
Professor of Neurological Surgery, University of Washington
The Holland lab works at the intersection of multiple disciplines to address the molecular basis of brain tumors and develop new approaches to their treatment. Our research focuses on developing mouse models of brain cancer that mimic the behavior of the disease in patients. Our work with mouse models has led to clinical trials in glioma patients. We also have developed imaging strategies to follow mouse brain tumors as they develop—a powerful system that is used to test promising new drugs with potential benefit for patients.
Phone: (206) 667-6117
Fax: (206) 667-7850
The Kemp Lab studies tumor formation in mice to better understand how environmental and genetic factors interact to cause cancer. They also work to develop simple blood tests for early cancer detection by discovering biomarkers, the proteins that signal the earliest traces of disease.
Phone: (206) 667-4252
Fax: (206) 667-5815
Intercellular communication and the control of cell growth.
Phone: (206) 667-5408
Fax: (206) 667-2537
Assistant Member, Human Biology Division
The MacPherson Lab is focused on understanding the mechanisms through which cancer-mutated genes drive tumorigenesis. The lab studies two tumor types, small cell lung carcinoma (SCLC) and retinoblastoma. Genomic analyses of human tumors allow us to identify gene mutations that may contribute to tumor initiation, progression and metastasis.
Phone: (206) 667-6464
Fax: (206) 667-2917
Member Emeritus, Basic Sciences Division
Member Emeritus, Human Biology Division
Cellular and viral oncogenes; normal and neoplastic B-cell development in the bursa of Fabricius; functional genomic analysis of somatic genomic instability in cancer
Phone: (206) 667-4417
Fax: (206) 667-6523
Dr. Peter Nelson's lab focuses on understanding the molecular, cellular and physiological events that lead to cancer initiation and progression. A particular emphasis involves hormonal carcinogenesis and prostate cancer with the goal of developing new strategies for diagnosis, prognosis and therapy.
Phone: (206) 667-3377
Fax: (206) 667-2917
The Overbaugh lab has a long-standing interest in understanding the mechanisms of HIV-1 transmission and pathogenesis. The lab is part of a larger team, comprising researchers in both Seattle and Kenya (The Nairobi HIV/STD Project). Trainees in the lab have opportunities to engage in studies of viral evolution, virus-host cell interactions, and viral immunology all within the context of international collaboration.
Phone: (206) 667-3524
Fax: (206) 667-6524
Assistant Member, Human Biology Division
The Paddison Lab uses functional genetics to probe the underlying biology of mammalian stem/progenitor cells. We identify and characterize gene products affecting stem cell self-renewal, differentiation, proliferation, or survival through the use of RNAi knockdown technologies.
Phone: (206) 667-4312
Fax: (206) 667-4023
The Peichel Lab uses a small fish called the threespine stickleback as a model organism to conduct research aimed at identifying the genetic and molecular mechanisms that underlie evolutionary processes. Research topics include understanding evolution of the fish's behavior and sex chromosomes.
Phone: (206) 667-1628
Fax: (206) 667-6523
The Porter Lab focuses on identifying and understanding the molecular events in normal and cancer cells that are associated with the initiation and progression of human cancer, with a focus on breast and ano-genital cancers. They also investigate the molecular profiles that distinguish different types of cancer or determine an individual's cancer risk.
Phone: (206) 667-3751
Fax: (206) 667-5815
The Reid Lab is focused on understanding the mechanisms by which environmental exposures (i.e. aspirin or other nonsteroidal antiinflammatory agents) affect the evolution of clones that lead to the development of esophageal adenocarcinoma in patients with Barrett's esophagus.
Fax: (206) 667-6192
Associate Member, Human Biology Division
Directly assessing the human t-cell receptor repertoire
Phone: (206) 667-2571
Fax: (206) 667-1319
The Salama lab studies the gastric bacterial pathogen Helicobacter pylori, which infects half the world's population and can cause ulcers and gastric cancer.
Phone: (206) 667-1540
Fax: (206) 667-6524
Associate Professor, University of Washington
Affiliate Investigator, Human Biology Division
The mission of the Shendure Lab is to develop and apply new technologies in genomics and molecular biology. Most projects in the lab exploit new DNA sequencing technologies, and generally fall into one of six areas: 1) next-generation human genetics; 2) genome contiguity & completeness; 3) massively parallel functional analysis; 4) molecular tagging; 5) synthetic biology; 6) translational genomics.
Phone: (206) 685-8543
Fax: (206) 685-7301
Associate Member, Clinical Research Division
Associate Member, Human Biology Division
The overarching goal of the projects in the Simon laboratory is the development of small molecules as mechanistic probes for a variety of cellular processes and as potential lead compounds for the development of therapeutic agents. To this end we apply an interdisciplinary approach ranging from chemical synthesis and medicinal chemistry to genetics and cell biology. The compounds we are studying have been identified from large collections of synthetic, drug-like compounds and from natural sources. While screening compound libraries is a significant part of what we do the majority of our efforts go into mechanistic studies to understand the biology and pharmacology of lead compounds and efforts to improve their activity through chemical synthesis of analogs.
Phone: (206) 667-6241
Fax: (206) 667-5669
Associate Member, Human Biology Division
The Taniguchi Lab's long-term research objective is to elucidate molecular mechanism of DNA damage response pathways, such as the Fanconi Anemia-BRCA (FA-BRCA) pathway, and their involvement in carcinogenesis.
Phone: (206) 667-7283
Fax: (206) 667-5815
The Tapscott Lab studies gene transcription and expression in normal development and disease, with an additional emphasis on rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other research areas include gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.
Phone: (206) 667-4499
Fax: (206) 667-6524
Member and Director Emeritus, Human Biology Division
The Vasioukhin lab studies the mechanisms and significance of cell polarity and cell adhesion in normal mammalian development and cancer. In addition, we have a significant interest in the mechanisms responsible for initiation and progression of human prostate cancer. We believe that it is important to study cells in their normal microenvironment.
Phone: (206) 667-1710
Fax: (206) 667-6524
Fred Hutchinson Cancer Research Center is a world leader in research to prevent, detect and treat cancer and other life-threatening diseases.