Public Health Sciences Labs & Projects
CANTRANce, or CANcer TRANslation for Comparative Effectiveness, is a modeling tool that provides a bridge from results concerning intermediate endpoints in cancer comparative effectiveness studies to disease-specific mortality.
One of the main challenges in the conduct of comparative effectiveness studies is that limitations in follow-up or data sources often require investigators to make inferences from intermediate endpoints rather than the endpoints of most interest. The primary endpoint of greatest interest for most cancer comparative effectiveness studies is disease-specific mortality. While models can provide mortality projections based on intermediate endpoints, they require investment and experience to build. CANTRANce is a user-friendly modeling framework that allows cancer researchers to use their studies of intermediate endpoints to estimate the impact of their interventions on mortality.
The framework is publicly available via a web application that enables study investigators to input their comparative effectiveness study results, identify key parameters necessary for the translation process, and select from a variety of mechanisms through which the intervention might affect disease-specific deaths. The framework will ultimately support the five different comparative effectiveness study types listed below. Links are provided for those web interfaces that are currently available for user modeling. Please also see the related manuscripts for examples of how each model may be used.
|Novel biomarkers||Sensitivity to detect disease|
|Screening tests||Stage distribution of detected cancers|
|Diagnostic Tests||Primary treatment distribution||Interface Manuscript|
|Primary treatment||Time to disease recurrence|
Please email Jeanette Birnbaum with questions or comments.