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A Study of Brentuximab Vedotin in Patients With CD30-positive Non-Hodgkin Lymphoma

Complete title: A phase 2 study of brentuximab vedotin in relapsed or refractory CD30-positive non-Hodgkin lymphoma (NHL)

Research Study Number       20110853
    
Principal Investigator       Andrei Shustov, MD
    
Phase       II

Look up trial at NIH

Research Study Description

This is a single-arm, open-label, multicenter, phase 2 clinical trial to evaluate the efficacy and safety of brentuximab vedotin as a single agent in patients with CD30-positive non-Hodgkin lymphoma (NHL).

Eligibility Criteria (must meet the following to participate in this study)

- Ages Eligible for Study: 6 Years and older

- Genders Eligible for Study: Both

- Histologically-confirmed CD30-positive NHL

- Relapsed or refractory disease following at least 1 prior systemic therapy

- Measurable disease of at least 1.5 cm as documented by CT

- ECOG performance status less than or equal to 2

Other eligibility criteria may apply.

Exclusions (conditions that would prevent participation in this study)

- History of another primary invasive malignancy that has not been in remission for at least 3 years

- Current diagnosis of systemic or cutaneous anaplastic large cell lymphoma or mycosis fungoides

- B cell lymphoma previously treated with only single-agent rituximab or corticosteroids as monotherapy

- Known cerebral/meningeal disease

Other exclusion criteria may apply.



Research Study Number       20110853
    
Contact       Seattle Cancer Care Alliance Intake Office
    
Telephone       800-804-8824 / 206-288-1024
    
   

Keywords
Hematologic Malignancies; Lymphoma; Non-Hodgkin's Lymphoma (NHL)

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