Multiple Sclerosis

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Multiple Sclerosis: Fast Facts

• Multiple sclerosis is an autoimmune disease, which means the body's immune system attacks its own tissues, resulting in inflammation. Like other autoimmune diseases, multiple sclerosis occurs more frequently in women than men.
• Multiple sclerosis impairs the central nervous system because the immune system specifically goes after a protein called myelin, which coats nerve fibers.
• Some multiple sclerosis patients have severe symptoms, including paralysis and the inability to move or feel due to nerve damage, but others suffer only from mild weakness or numbness. These symptoms can be persistent or periodic and may also include loss of balance, loss of coordination and tremors.
• Scientists suspect there is a genetic component to multiple sclerosis, as certain families have an increased predisposition to autoimmune diseases in general. The incidence of multiple sclerosis is higher in the most northern latitudes, suggesting environmental factors may also be at play. A viral infection may also trigger the disease's onset in genetically predisposed individuals.

Learn more about autoimmune diseases at the Seattle Cancer Care Alliance.

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Multiple Sclerosis: Some of our Key Research

Developing a drug to prevent multiple-sclerosis relapse
A breakthrough drug for treatment of patients with relapsing forms of multiple sclerosis arose from a method developed by Dr. Elizabeth Wayner beginning in the late 1980s. Known as Tysabri® (Natalizumab), the drug uses an antibody — that is, a type of immune-system protein that binds exclusively to another protein — to prevent the inflammation associated with multiple sclerosis.

Tysabri may also prove beneficial for patients with other autoimmune diseases, such as lupus, Crohn's disease and rheumatoid arthritis, as well as melanoma, a serious form of skin cancer. Learn more. »

Using transplantation to treat severe autoimmune diseases
Dr. Richard Nash and colleagues are leading clinical trials to examine the feasibility of high-dose chemotherapy and stem-cell transplantation – the standard treatment for leukemia and other blood cancers – in treating severe forms of autoimmune diseases, including multiple sclerosis, systemic lupus and scleroderma (also known as systemic sclerosis). Their early results have been promising, prompting larger studies.

With transplantation, it may be possible to remove the reactive cells that are triggering the immune system to attack the body. In such a transplantation, a patient's stem cells are collected, and cells that react against the patient's own tissue are removed. Next, the patient undergoes high-dose chemotherapy and takes drugs to suppress their immune system. The patient then receives an infusion of the stem cells that were collected before treatment, with the goal of rebuilding a new, healthier immune system. Learn more. »

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Multiple Sclerosis: More Resources

• Advances in disease treatment in recent years have come out of clinical trials that test innovative medical approaches on patients. Find out more about clinical trials on multiple sclerosis. »

• The Hutchinson Center conducts ongoing studies that depend on participation of healthy volunteers. Learn more about getting involved in research studies. »

• The Hutchinson Center is on a mission to eliminate cancer and related diseases as causes of human suffering and death, and you can help. Make a gift today. »

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