Pilot Research Project Four

Metabolic Responses to Hypoxia

Co-Principal Investigators:
Wayne Van Voorhies, Ph.D. – NMSU
Mark Roth, Ph.D. – FHCRC

The goal of this research is to better understand the metabolic state of animals that are deprived of oxygen. In this initial pilot project phase we will adapt methods for analyzing metabolism energetics and oxidative damage to studying the model organism zebrafish (Danio rerio). We will apply these methods:

	To determine the response of the metabolism and intracellular energetics of zebrafish embryos to varying oxygen tensions at different periods in development.
	To define the extent of oxidative damage that results from alterations in the oxygen levels.
	To develop and begin to test hypotheses about mechanisms of surviving hypoxia that may be common to zebrafish and tumors.

This project will allow us to bring together the expertise of investigators from FHCRC and NMSU to develop a research project that neither institute could perform alone. Our common interest in measuring, understanding and manipulating oxidative stress in organisms makes this a natural collaboration that has direct implications for the treatment of cancer.

For More Information:

To learn about the work of Dr. Mark Roth's research laboratory at the FHCRC, visit http://www.fhcrc.org/labs/roth/.

Interested NMSU faculty and students may contact Dr. Wayne Van Voorhies at wvanvoor@nmsu.edu or Dr. Mark Roth at mroth@fhcrc.org to learn more about this pilot research project.