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Lawrence Corey, MDHead Head Member Professor |
Dr. Corey serves as the joint head of Fred Hutchinson Cancer Research Center Clinical Research Division's Program in Infectious Diseases and the Virology Division of the University of Washington's Department of Laboratory Medicine. Dr. Corey specializes in herpesvirus, HIV and other infectious disease-related research. He participates in many projects at the Center and throughout the research community. Some of the projects in which Dr. Corey is currently involved in are listed below.
The Herpes Virus Research programs involve studies in HSV, CMV, HHV-6 and HHV-8. The genital HSV program has been the most longstanding, having had NIH funding since 1978. This program involves clinical investigations of HSV reactivation and transmission; laboratory based studies on the cellular immunology of HSV and studies of HSV-HIV interactions. In the last few years the laboratory has emphasized developing an HSV vaccine. The context of this is to define the T cell responses to HSV, especially cytotoxic T cell responses as a means of developing a CTL-based vaccines for both immunotherapy and prophylaxis of genital HSV. The laboratory-based programs are done in concert with Drs. David Koelle, Associate Professor of Medicine and Chris Posavad, Research Assistant Professor of Laboratory Medicine. The Clinical Research Program in genital herpes is directed by Dr. Anna Wald, Associate Professor at the University of Washington. A special clinic dedicated to a wide range of clinical studies on the frequency of HSV resolution, prevalence of HSV acquisition by vaccines and novel theories for HSV infections.
The Program in HHV-8 infection is interested in studies of the transmission of HHV-8 and defining the interactions between HHV-8 and epithelial cells, especially the mechanism of salivary excretion of HHV-8. This work is done with Dr. Anna Wald, Associate Professor of Medicine, Dr. Corey Casper, Acting Instructor in Medicine, and Jeff Vieira, Ph.D., Research Assistant Professor of Laboratory Medicine.
The FHCRC Program in Infectious Diseases is interested in the prevention of CMV and HHV-6 infections in the immunocompromised host and the role these infections play in the morbidity of HSCT. This work is led by Dr. Michael Boeckh at the Center.
The HIV Research Program also directed by Dr. Corey involves both laboratory and clinical investigation. Dr. Corey is the PI of the NIAID supported HIV Vaccine Trials Network, a global network of clinical trials sites and laboratories dedicated to Phase I-III trials of candidate HIV vaccines. Other faculty involved in the effort are Drs. Judith Wasserheit, Steve Self, and Julie McElrath. Training opportunities for post doctoral fellows interested in learning vaccine biology and clinical trials are available within the context of the network. The HIV laboratory program is devoted to defining persistent reservoirs of HIV infection. Laboratory work is coordinated with Tuofu Zhu and Jim Mullins of the University of Washington and Dr. Julie McElrath at the FHCRC.
Click on a project to view a detailed report of the project and see some relevant pictures and lists of publications. Each list of publications is not necessarily a complete list. However, the lists give Dr. Corey's most recent publications that pertain to his research projects.
- Herpes Simplex Virus (HSV) Infections
- The Virology Lab Core
- Cytotoxic T Cell Responses to HSV in HIV Infected Persons
- Human Herpesvirus 8: Epidemiology and Natural History
- HIV Programs
- HIV Vaccine Program (HVTN)
- Biologic Activity of Transferred HIV-Specific CD8 Clones
- Transmission and Acquisition of Human Herpesvirus 8
- Immunology of Primary HIV-1 Infection
- Program Project: Clinical Epidemiology and Pathogenesis of Asymptomatic HSV
- Cytotoxic T-Cell Responses to HSV in HIV-Infected Persons
- Molecular Diagnostic Laboratory
- HSV Infection in HIV Infected Individuals
- Viral Diagnostic Laboratory
