Research Initiatives:
1. Clinical Studies in fungal infections. Clinical studies are underway and in development, with the focus on preventing fungal infection, which have become leading infections in HSCT recipients. This includes randomized antifungal therapy trials in myelobative and non-myelobative transplant recipients, and multiple studies to determine performance characteristics and optimal testing methods for new diagnostic assays.
2. Epidemiology of Invasive Fungal Infections (IFI) in HSCT patients.
A database has been created to identify IFIs in our institution, dating back to 1985. Multiple studies are
underway to understand infections risks.
Publications
1. Marr KA , Seidel K, Slavin MA, Bowden RA, Schoch HG, Flowers MED, Corey L, and M Boeckh. Prolonged fluconazole prophylaxis is associated with persistent protection against candidiasis-related death in allogeneic marrow transplant recipients: long-term follow-up of a randomized, placebo-controlled trial Blood 96 (6):2055 (2000).
2. Marr KA , Seidel K, White TC, and RA Bowden. Candidemia in blood and marrow transplant recipients: evolution of risk factors after the adoption of prophylactic fluconazole J Infect Dis 181:309-16 (2000).
3. Marr KA, Carter R, Crippa F, Wald A, Corey L. Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients Clin Infect Dis 34:909-17 (2002).
4. Crippa F, Holmberg L, Carter RA, Hooper H, Marr KA , Bensinger W, Chauncey T, Corey L, and Boeckh M. Infectious complications after autologous CD34 selected peripheral blood stem cell transplantation. Biol Blood Marrow Transplant ; 8:281-89 (2002).
5. Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, Kern W, Marr KA , Ribaud P, Lortholary O, Sylvester R, de Pauw B. Randomized comparison of voriconazole and amphotericin B in primary therapy of invasive aspergillosis. A collaborative study of the EORTC invasive fungal infection group and the global aspergillosis study group. New Engl J Med 347:408-15 (2002).
6. Junghanss C, Marr KA , Carter RA, Sandmaier B, Maris MB, Maloney DG, Chauncey T, Storb R. Incidence and outcome of bacterial and fungal infections following nonmyeloablative compared with myeloablative allogeneic hematopoietic stem cell transplantation: a matched control study. Biol Blood Marrow Transplant . 2002;8(9):512-20.
7. Marr KA, Carter RA, Boeckh M, Martin P, Corey L. Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risks. Blood 10(13):4358-66 (2002).
8. Fukuda T, Boeckh M, Carter R, Sandmaier B, Maris M, Maloney D, Martin P, Storb R, Marr KA . Invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplantation after nonmyeloablative conditioning: risks and outcomes . Blood (in press, 2003)
