Mutations affecting Cellular Processes

Cancer cells clonally evolve as a result of specific mutations that lead to the following characteristics of cancer cells.

• loss of normal cell differentiation or inability to undergo normal cell death (apoptosis)
  
  
• unregulated cell proliferation
  
  
• genomic instability

	Cell Differentiation
	Mutations Affecting Cellular Processes
	Accumulation of Mutations in Cancer
	Cell Proliferation
	Genomic Instability
	Familial Cancers