Cell proliferation

Cell proliferation is controlled by

• Growth factors that bind to...
  
  
• Receptors on the cell surface that connect to...
  
  
• Signaling molecules (signal transduction pathway ) that convey message from receptor to the nucleus where...
  
  
• Transcription factors bind to DNA, turning on or off the production of proteins that...
  
  
• Cause cells to continue dividing.

Mutations in any of the genes encoding these types of proteins can affect proliferation and many examples have been found in cancer cells. For example, several mutations affecting different proteins that regulate one part of the cell cycle (G1 to S phase) have been consistently seen in many tumors.

	Cell Differentiation
	Mutations Affecting Cellular Processes
	Accumulation of Mutations in Cancer
	Cell Proliferation
	Genomic Instability
	Familial Cancers