Conj 533
The Dynamic Chromosome (1.5 Credits)
Autumn 08— Weeks 1-5; 9/25-10/28/08
Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizer: Sue Biggins (FHCRC/UW Genome Sciences & Biochemistry Affiliate)
This course is a graduate level introduction to the chromosome, viewing it as the ultimate organelle. It will focus on understanding how chromosomes are maintained and propagated. It will use a combination of lecture, literature review, and in class discussion to explore genetic, biochemical, and cytological methods for defining our current knowledge about chromosomes. The course requires students to have taken undergraduate cell biology, biochemistry and genetics.
*For more information about the course contact Sue Biggins, (206) 667-1351
Conj 534
Nervous System Development (1.5 Credits)
Winter 08 — Weeks 6-10; 2/12-3/13/08
Location: FHCRC, Day Campus; Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizers: Jon Cooper (FHCRC/UW Biochemistry Affiliate); Cecilia Moens (FHCRC/UW Biology & BMSD Affiliate)
This course will cover basic principles of nervous system development, but will not cover mechanisms of synaptic signaling or electrical activity. Our emphasis will be on the vertebrate nervous system, but we will discuss principles gleaned from studies of invertebrate neural development as well. The course combines faculty lectures and student-run discussions of key papers in the field. This course follows conceptually from CONJ 542, “Early Vertebrate Development”, which is held in the first half of Winter Quarter. Students are encouraged although not required to take both courses.
*For more information about the course contact Jon Cooper, (206) 667-4454 or Cecilia Moens, (206) 667-5627
Conj 535
RNA Structure and Biological Function (1.5 Credits)
Winter 08 — Weeks 6-10; 2/12-3/13/08
Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizers: Adrian Ferré-D'Amaré (FHCRC/UW Biochemistry Affiliate)
Survey of the diversity of cell-biological roles played by RNA with emphasis on structural principles and structure-function relationships. Readings from classic and current literature to cover both, methods for the study of RNA, and examples of the function of this nucleic acid as part of the machinery of gene expression.
At least a semester of undergraduate biochemistry (or equivalent) required.
A semester (or more) of undergraduate physical chemistry would be a plus.
Grades will be based on quizzes on the assigned primary literature.
*For more information about the course contact Adrian Ferré-D'Amaré
Conj 537
Mechanisms of Transcriptional Regulation (1.5 Credits)
Autumn 07 — Weeks 6-10; 11/1 -12/6/07
Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizer: Toshio Tsukiyama (FHCRC/UW Biochemistry Affiliate)
A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Transcriptional regulation, development and diseases in mammals (Steve Tapscott).
*For more information about the course contact Toshio Tsukiyama
Conj 539
Biological Basis of Neoplasia (1.5 Credits)
Spring 08 — Weeks 6-10; 5/6-6/5/08
Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizer: *Chris Kemp (FHCRC/UW Pathology Affiliate)
This course allows students to gain experience in applying the several disciplines which comprise cellular and molecular biology toward a deeper understanding of a complex biological problem: neoplastic change. The course consists of a series of lectures to introduce students to the major themes in research in the cellular and molecular biology of neoplastic change. They cover principal cancer phenotypes, oncogenes, tumor suppressor genes, genetic instability and mutator phenotypes, loss of tissue homeostasis and senescence and chemical carcinogenesis. The lectures are supplemented by in-class student discussions of focus topics lead by a scientist working on the selected problem.
Prerequisites: Introductory biochemistry and cell biology.
Additional Information and Course Syllabus
*For more information about the course contact Chris Kemp, (206) 667-4252.
Conj 544
Protein Structure, Modification and Regulation (1.5 Credits)
Winter 08 — Weeks 1-5; 1/8 - 2/7/08
Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/74
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructors: B. L. Stoddard (FHCRC/UW Biochemistry Affiliate)
Readings: Selected papers from primary literature.
We will provide an overview of general principles of protein structure, including (i) forces and interactions that contribute to folding, dynamics and stability, (ii) the structural and functional effects of post-transcriptional and post-translational splice variation, (iii) covalent chemical modification of protein side chains, (iv) the functional effects of ligand binding via cooperativity and allostery, and and (v) diversification of protein fold and function during evolution.
Background and Prerequisites: The course will assume knowledge at the level of an advanced undergraduate biochemistry course. Knowledge in the areas we will discuss at the level of Stryer Biochemistry or Alberts Molecular Biology of the Cell will be assumed.
For More Information and Course Overview
Conj 551
Immunity (1.5 Credits)
Spring 08 — Weeks 1-5; 4/1 - 5/1/08
Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/74
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructor: Roland K. Strong (FHCRC/UW Immunology Affiliate)
Readings: Selected chapters from Abbas & Lichtman, Cellular & Molecular Immunology, 5th edition, and papers from the primary literature.
The goal of this course is to provide an understanding of the workings of the central cellular and molecular players in the mammalian immune system, at a level appropriate for the non-specializing graduate student. Classes will be run as discussions of the assigned readings. The selective topics will include the molecular basis of B and T cell activation and effector functions, as well as an introduction to the mechanisms of innate immunity. The course grade will be based upon written critiques and in-class oral presentations of seminal papers from the current and classic literature.
Prerequisites: A basic understanding of molecular biology and biochemistry from undergraduate- and prior graduate-level courses as well as permission of the instructor. Course size will be limited to ten (auditors are welcome).
*For more information about the course contact Roland Strong, (206) 667-5587.
Conj 552 - Fall
Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/74
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructor: Dan Gottschling (FHCRC/Genome Sciences Dept. Affiliate), David Hockenbery (FHCRC/Dept. of Medicine Affiliate), Mark Roth (FHCRC/Biochemistry Dept. Affiliate)
This course will focus on small molecules and the ways that the chemistry of these molecules facilitates life under changing conditions. It will include systems from microbiology to human physiology to understand aspects of cancer, aging, and animation. A combination of lecture and in class discussion will be used to explore topics including bioenergetics/metabolic flux, adaptation, and allometric scaling.
Prerequisites: Undergraduate organic chemistry and biochemistry. Evaluations will be made based on assigned problem sets. Graduate students only. No auditors. Course limited to 25 students.
*For more information about the course contact Mark Roth, (206) 667-5602.
Genetics
MCB / FHCRC 517 Topics
DNA Repair and Genetic Recombination (3 Credits)
*Gerry Smith
This course emphasizes the critical analysis of data, using DNA repair and recombination as an example. The goals are to help students critically analyze scientific literature, to introduce them to a current subject in molecular and cellular biology, and to aid them in public presentations. The instructor will give short lectures for background, followed by detailed discussion of one to three papers from classical and current literature. Weekly problem sets are assigned. Winter or Spring; Biannually; Meets once weekly for 3 hours.
*For more information contact Gerry Smith, (206) 667-4438.
Virology
MCB / FHCRC 532
Human Pathogenic Viruses (3 Credits)
*Michael Emerman
This course will cover the molecular biology and pathogenesis of major groups of human viruses, including retroviruses, flaviviruses, herpesviruses, influenza viruses, poliovirus, papillomaviruses, and others. The class will meet on Tuesdays and Thursdays from 1:30 to 3:00 PM. Course registration is limited to 16. Fall 08/09; FHCRC Rooms B1-072 & 074; 1:30 - 3:00pm
*For more information contact Michael Emerman, (206) 667-5058.
Additional Information and Course Syllabus
Cell Biology
MCB / FHCRC 511
Cell Cycle Control (3 Credits)
*L. Breeden, B. Edgar
A focus of this course is on the recent advances in understanding the control of the cell cycle. Information will be drawn from genetic and biochemical studies of fission and budding yeast, marine invertebrates, Drosophila, amphibians, and mammalian culture cells. This course will also address the biochemical processes and molecular interactions that are necessary for chromosome duplication. There will be discussion of rate-limiting events and study of how those events are coupled to the physiological signals that control cell proliferation. Some lectures will be given by outside experts. The class will meet for 1.5 hours twice per week. Spring 08/09
*For more information contact Linda Breeden, (206) 667-4484.
Developmental Biology
MCB / FHCRC 521
Embryos, Genes, and Development (4 Credits)
*S. Parkhurst, J. Priess, P. Soriano
This course will provide a thorough introduction to vertebrate and invertebrate development emphasizing cellular, genetic and molecular mechanisms. The course will focus primarily on development of fruit flies, nematodes, and mice. Emphasis will be on understanding fundamental embryological processes such as induction, determination, and pattern formation. The relationship between development and evolution will also be explored. Current technologies such as transgenic animals, genetics, mosaic analysis, homologous recombination, somatic cell genetics, and classical embryonic manipulations will be analyzed. Selected topics include developmental genetics of regulatory hierarchies, lateral inhibition, limb regeneration and development, cell lineage analysis, myogenesis and neurogenesis, X-chromosome inactivation, imprinting, and sex determination. Following introductory lectures, the course will focus on primary literature detailing the current state of the field using journal club presentations (by students). Winter 08/09
*For more information contact Susan Parkhurst, (206) 667-6466.
Structural Biology
MCB / FHCRC 542
Nucleic Acids and Enzymes (2 Credits)
*B. Stoddard
This elective will cover the structure/function relationships of enzymes that act on DNA and RNA. The course will focus both on various molecular systems, and also on important techniques used for their study, including high resolution structure determination, single molecule methods, kinetics and thermodynamic binding analyses, and protein engineering.
Students will be graded on a combination of presentation and organization of an assigned paper from the primary literature, and a written fellowship-style proposal at the end of the quarter.
Background and prerequisites: Students should have a strong background in undergraduate biochemistry, and hopefully have taken Conjoint 544 "Protein Structure, Modification and Regulation".
Spring 07/08
*For more information contact Barry Stoddard, 206) 667-4031 or go to the Stoddard Lab Page
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