Linkage analysis is a powerful method for identifying disease genes. Recent
dramatic improvements in sequencing render it a potential tool for marker
acquisition and genotyping in linkage studies. However, the prospects
of using this technology, as well as the possible limitations, have not been
studied so far.
In this collaborative project we intend to explore the properties of sequence-based
linkage analysis. We will study the variation among family members
expected to be found by sequencing and compare it with empirical human data.
We will then study the informativeness of a sequence-based marker map
as a function of sequence-stretch length and spacing. Finally, we will
apply the approach to dog pedigrees.
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