Liver – Korea Research Institute for Bioscience & Biotechnology (Coordinating Center)
| Project Title: | Research and Development of Cancer Biomarkers for Gastric and Liver Cancers | |
| Cancer Site: | Liver | |
| Principal Investigator(s): | Hyang-Sook YOO, Ph.D. | |
| Participating Institutions: |
Korea Research Institute for Bioscience & Biotechnology (KRIBB – Coordinating Center)
Chungnam National University General Hospital (CNUGH) Eulji University Hospital (EUH) Korea Cancer Center Hospital (KCCH) Korea Basic Science Institute (KBSI) Fred Hutchinson Cancer Research Center (FHCRC) |
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| Mouse Model(s): |
Liver cancer mouse model
Gastric cancer mouse model
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| Technical Approaches: |
2D gel electrophoresis
Glycoprotein capture Human protein tyrosine and dual specificity phosphatase (PTP) antibody chip Mass spectrometry Phosphoprotein capture primarily using Immobilized Metal Affinity Column (IMAC) method Small molecule microarray Restriction Length Genome Scanning for profiling of DNA methylation change of cancer tissue |
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Brief Description of Project:
Cancer is the first cause of deaths in Korea with annual incidence of over 100,000 cases and the cost for diagnosis and treatment is over 1.3 trillion Won. It is an emerging consensus among physicians and oncologists that early detection of cancer is the most promising way of treating the disease and decreasing the death rate.
The advent of new and sensitive proteome analysis technologies has opened new possibilities of developing biomarkers in serum, which can be utilized in the diagnosis of early cancers through a casual blood test. The current technologies allow detection of low femtomole quantity proteins in appropriate experimental conditions. In addition to the sensitivity, many other technologies have been developed in the area of enrichment of low abundant proteins in serum, sensitive protein tagging, and high throughput proteome analysis.
The nature of massive sample analysis and new technology dependence in the efficient discovery of clinically useful biomarkers has led to the proposal and formation of national and international collaborative networks. Fred Hutchinson Cancer Research Center (FHCRC) is leading an international consortium on the biomarker discovery, which could facilitate the material and technology sharing, and collective analysis of large and diverse data.
In the current project, we will carry out a biomarker discovery program in collaboration with the international efforts led by FHCRC. We will serve as a branch site of the international consortium and conduct a massive biomarker discovery study concentrated on cancers such as gastric and liver cancer that affect the Korean population.
Team Members and Expertise:
Kwang Hee BAE, Ph.D. (KRIBB) [khbae@kribb.re.kr]
Proteomics
Jonghwa BHAK, Ph.D (KRIBB) [jong@kribb.re.kr]
Bioinformatics
Eun Wie CHO, Ph.D. (KRIBB) [ewcho@kribb.re.kr]
Proteomics
In-Pyo CHOI, Ph.D. (KRIBB) [ipchoi@kribb.re.kr]
Immune escape and gastric cancer
Hyo Jeong HONG, Ph.D. (KRIBB)
Antibody Engineering
Sung Hyun KANG, Ph.D. (KRIBB) [skang@kribb.re.kr]
Proteomics
Jin Young KIM, Ph.D. (KBSI) [jinyoung@kbsi.re.kr]
Proteomics
Seung Ho KIM, Ph.D. (KRIBB) [shkim@kribb.re.kr]
Proteomics
Yong Sung KIM, Ph.D. (KRIBB) [yongsung@kribb.re.kr]
Coordinator of Tissue Banking
DNA methylation profiling of gastric cancer
Mouse model of gastric cancer
Jeong Heon KO, Ph.D. (KRIBB) [jhko@kribb.re.kr]
Proteomics
Kyung Hoon KWON, Ph.D. (KBSI) [khoon@kbsi.re.kr]
Proteomics
Sang Chul LEE, Ph.D. (KRIBB) [lesach@kribb.re.kr]
Proteomics
Seong-Eon RYU, Ph.D. (KRIBB) [ryuse@kribb.re.kr]
Proteomics team leader
Hyang-Sook YOO, Ph.D. (KRIBB—Biomarker Team PI) [yoohyang@kribb.re.kr]
Leader of Functional Genome Project of Korea focusing on gastric and liver cancer genome analysis
Jong Shin YOO, Ph.D. (KBSI) [jongshin@kbsi.re.kr]
Mass Spectometry
Proteomics
Tae Sung YOON, Ph.D. (KRIBB) [yoonts@kribb.re.kr]
Proteomics
Dae-Yeul YU, Ph.D. (KRIBB) [dyyu10@kribb.re.kr]
Mouse model of liver cancer
Ung Sik YU, Ph.D. (KRIBB) [ungsik@kribb.re.kr]
Bioinformatics
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