Publications

2007

Sawyer, S.L., Emerman, M., and Malik, H.S.

Discordant Evolution of the Adjacent  Antiretroviral Genes TRIM22 and TRIM5 in Mammals (2007) PLoS Pathog., 3 (12) 1918-1929 Abstract / Full Text

Yamashita, M., Perez, O., Hope, T.J., and Emerman, M.

Evidence for Direct Involvement of the Capsid Protein in HIV Infection of Nondividing cells. (2007) PLoS Pathog., 3 (10) 1502-1510. Abstract / Full Tex

Voronin, Y., Chohan, B., Emerman, M., and Overbaugh, J.

Primary Isolates of Human Immunodeficiency Virus 1 (HIV-1) are Usually Dominated by the Major Variants Found in Blood. (2007) J. Virol. 81: 10232-10241. Abstract / Full Text

Kaiser, S.M., Malik, H.S., and Emerman, M.

Restriction of an Exinct Retrovirus by the Human Trim5a Antiviral Protein (2007) Science 316:1756-1758. Abstract / Full Text

2006

Yamashita, M., and Emerman, M.

Retroviral Infection of Non-dividing Cells: Old and New Perspectives. (2006) Virology, 344: 88-93. Abstract / Full Text

Kaiser, S.M., and Emerman, M.

Uracil DNA Glycosylase is Dispensable for HIV-1 Replication and Does Not Contribute to the Antiviral Effects of the Cytidine Deaminase, Apobec3G. (2006) J. Virol., 80:875-882. Abstract / Full Text

Sawyer, S.L., Wu, L., Akey, J.M., Emerman, M., and Malik, H.S

High Frequency Persistence of an Impaired Allele of the Retroviral Defense Gene TRIM5a in Humans. (2006) Current Biology, 16: 95-100. Abstract / Full Text

OhAinle, M., Kerns, J.A., Malik, H.S., and Emerman, M.

Adaptive Evolution and Antiviral Activity of the Conserved Mammalian Cytidine Deaminase APOBEC3H. J. Virol. (2006). J. Virol., 80: 3853-3862. Abstract / Full Text

Emerman, M.

How Trim5α defends against retroviral invasions. (2006) Proc. Nat. Acad. Sci. (USA), 103: 5249-5250. Abstract / Full Text

Lewinski MK, Yamashita M, Emerman M, Ciuffi A, Marshall H, et al.

Retroviral DNA Integration: Viral and Cellular Determinants of Target-Site Selection. (2006) PLoS Pathog 2(6): e60 Full Text

 

Lin, T-Y. , Emerman, M.

Cyclophilin A interacts with diverse lentiviral capsids. (2006) Retrovirology 3: 70. Abstract/ Full Text

 

2005

Sawyer, S.L., Wu, L., Emerman, M., and Malik, H.S.

Positive selection in primate Trim5a identifies a critical species-specific retroviral restriction. (2005) Proc. Natl. Acad. Sci. USA 102: 2832-2837. Abstract / Full Text

Yamashita, M., and Emerman, M.

The Cell Cycle Independence of HIV Infections is Not Determined by Known Karyophilic Viral Elements. (2005) PLoS Pathog 1 (3) e18: 170-178. Abstract / Full Text

Voronin, Y., Overbaugh, J., and Emerman, M.

SIV Variants that Differ in Pathogenicity Differ in Fitness under Rapid Cell-turnover Conditions. (2005) J. Virol. 79: 15091-15098. Abstract / Full Text

2004

Goh, W.C., Manel, N. , and Emerman, M.

The Human Immunodeficiency Virus Vpr Protein Binds Cdc25C: Implications for G2 arrest (2004) Virology, 318: 338-351. Abstract / Full Text

Kaiser, S.M., and Emerman, M.

Controlling lentiviruses: Single amino acid changes can determine specificity (2004). Proc. Natl. Acad. Sci. USA, 101, 3725-3726. Abstract / Full Text

Yamashita, M., and Emerman, M.

Capsid is a dominant determinant of retroviral infectivity in non-dividing cells. (2004) J. Virol.,78:5670-5678. Abstract / Full Text

Sawyer, S.L., Emerman, M., and Malik H. S.

Ancient, Positive Selection of the Antiviral DNA Editing Enzyme Apobec3G in Primates (2004) PLoS Biology 2: 1278-1285. Abstract / Full Text

2003

Gummuluru, S., and Emerman, M.

AIDS 2002, A Year in Review: Advances in HIV molecular biology. (2003) AIDS, 16, S17-S24. Abstract

Gummuluru, S., Rogel M., Stamatatos, L., and Emerman, M.

Binding of human immunodeficiency virus type 1 to immature dendritic cells can occur independently of DC-SIGN and mannose binding C-type lectin receptors via a cholesterol dependent pathway. (2003) J. Virol. 77: 12865-12874. Abstract / Full Text

2002

Lewinsohn, D.A., Lines, R., Lewinshohn, D.M., Riddell, S. R., Greenberg, P.D., Emerman, M., and Bartz, S.R.

HIV-1 Vpr does not inhibit CTL-mediated apoptosis of HIV-1 infected cells. (2002) Virology 294, 13-30.

Somasundaran, M., Sharkey, M., Brichacek, B., Luzuraga, K. Emerman, M. Sullivan, J., and Stevenson, M.

Evidence for a cytopathogenicity determinant within HIV-1 Vpr. (2002) Proc. Natl. Acad. Sci. USA 99: 9503-9508.

Gummuluru, S., KewalRamani, V.N., and Emerman, M.

Dendritic Cell Mediated viral transfer to T cells is required for HIV-1 Persistence in the Face of Rapid Cell Turnover. (2002), J. Virol, 76, 10692-10701.

McDonald, D. , Vodicka, M. , Lucero, G. , Svitkina, T.M. , Borisy, G.G., Emerman, M., and Hope, T.J.

Visualization of the intracellular behavior of HIV in living cells. (2002) Journal of Cell Biology, 159, 441-452.

Dvorin, J.D., Bell, P., Maul, G.G., Yamashita, M., Emerman, M., and Malim, M. H.

Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type-1 nuclear import. (2002), J. Virol. , 76, 12087-12096.

2001

Malim, M. H. and Emerman, M.

(2001) HIV-1 sequence variation: drift, shift, and attenuation. Cell 104, 469-472.

Bouyac-Bertoia, M., Dvorin, J.D., Fouchier, R.A.M., Jenkins, Y., Meyer, B.E., Wu, L.I., Emerman, M., Malim, M.H.

(2001) HIV-1 infection requires a functional integrase NLS. Molecular Cell, 7, 1025-1035.

2000

Emerman, M.

(2000) Learning from Lentiviruses. Nature Genetics 24, 8-9.

Holte, S. and Emerman, M.

(2000) A competition model for viral inhibition of host cell proliferation. Mathematical Biosciences. 166 :69-84.

Harrington R. Wu L. Pullen H. Emerman M.

(2000) Direct detection of infectious HIV-1 in blood using a centrifugation-indicator cell assay. Journal of Virological Methods. 88 :111-115.

Gummuluru, S., Kinsey, C. M., Emerman, M.

(2000). In vitro rapid turnover assay for HIV-1 replication selects for cell-to-cell spread. J. Virol. 74, 10882-10891.

1999

Bartz, S.R. and Emerman, M.

(1999) HIV-1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/Caspace-8. J. Virol, 73, 1956-1963.

Goh, W.C., Markee, J., Akridge, R.E, Meldorf, M., Musey, L., Karchmer, T., Krone, M., Collier, A., Corey, L., Emerman, M., and McElrath, M.J.

(1999) Protection against HIV-1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 co-receptor defects. J. Infect. Dis. 179: 548-557.

Gummuluru, S. and Emerman, M.

(1999) Cell Cycle and Vpr-Mediated Regulation of HIV-1 Expression in Primary and Transformed T Cell Lines. J. Virol., 73, 5422-5430.

1998

Goh, W. C, Rogel, M.E, Kinsey, C.M. , Michael, S.F., Fultz, P.N., Nowak, M.A., Hahn, B.H., and Emerman, M.

(1998) HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo. Nature Medicine, 4, 65-70.

Vodicka, M.A., Koepp, D.M., Silver, P.A., and Emerman, M.

(1998) HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. Genes & Dev.,12, 175-185.

Emerman, M. and Malim, M.H.

(1998) HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology. Science, 280, 1880-1884.

1997

Selig, L., Benichou, S., Rogel, M. E. , Wu, L. I. , Vodicka, M. A., Sire, J., Benarous, R., and Emerman, M.

(1997) Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest. J. Virol., 71, 4842-4846.

Stivahtis, G.L., Soares, M.A., Vodicka, M.A., Hahn, B.H., and Emerman, M.

(1997) Conservation and host-specificity of Vpr-mediated cell cycle arrest suggest a fundamental role in primate lentiviral evolution and biology. J. Virol., 71 , 4331-4338.

Gu, J., Emerman, M., and Sandmeyer, S.

(1997) Small heat shock protein suppression of Vpr-induced cytoskelatal defects in budding yeast. Mol. Cell. Biol. , 17, 4033-4042.

Vodicka, M.A., Goh, W. C. , Wu, L.I. , Rogel, M.E., Bartz, S.R. Schweickart, V.L., Raport , C.J., and Emerman, M.

(1997) Indicator cell Lines for detection of primary strains of human and simian immunodeficiency viruses. Virology, 233, 193-198.

1996

Bartz, S.R., Rogel, M.E., and Emerman, M.

(1996) HIV-1 Vpr cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control. J. Virol., 70, 2324-2331.

KewalRamani, V.N., and Emerman, M.

(1996) Vpx association with mature core structures of HIV-2. Virology, 218, 159-168.

KewalRamani, V.N., Park, C., Gallombardo, P., and Emerman, M.

(1996) Protein stability influences human immunodefiency virus type 2 Vpr virion incorporation and cell cycle effect. Virology, 218, 326-334.

Emerman, M.

(1996) From curse to cure: HIV for gene therapy? Nature Biotechnology, 14, 943.

Emerman, M.

(1996) HIV, Vpr, and the cell cycle. Current Biology, 6, 1096-1103.

Fletcher, T.M., Brichacek, B., Sharova, N., Newman, M.A., Stivahatis, G., Sharp, P.M., Emerman, M., Hahn, B.H., and Stevenson, M.A.

(1996) Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIVSM. EMBO J., 15, 101-111.

Sharp, P.M., Bailes, E., Stevenson, M.A., Emerman, M., and Hahn, B.H.

(1996) Gene acquisition in HIV and SIV. Nature, 383, 586-587.

Selected publications 1990-1995

Rogel, M.E., Wu, L.I., and Emerman, M.

(1995) The HIV-1 vpr gene prevents cell proliferation during chronic infection. J. Virol. 69, 882-888.

Heinzinger, N., Bukrinsky, M., Haggerty, S., Ragland, A., KewalRamani, V., Lee, M., Gendelman, H., Ratner, L., Stevenson, M., and Emerman, M.

(1994) The Vpr protein of HIV-1 influences nuclear targeting of viral nucleic acids in non-dividing host cells. Proc. Natl. Acad. Sci. (USA) 91, 7311-7315.

Lewis, P., and Emerman, M.

(1994) Passage through mitosis is required for onco-retroviruses, but not for the human immunodeficiency virus. J. Virol. 68: 510-516.

Deminie, C., and Emerman, M.

(1993) Incorporation of human immunodeficiency virus Gag proteins into murine leukemia virus virions. J. Virol. 67, 6499-6506.

Bukrinsky, M.I., Haggerty, S., Dempsey, M.P., Sharova, N., Adzubei, A., Spitz, L., Lewis, P., Goldfarb, D., Emerman, M., and Stevenson, M.

(1993) A nuclear targeting signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature 365, 666-669.

Lewis, P., Hensel, M., and Emerman, M.

(1992) Human immunodeficiency virus infection of cells arrested in the cell-cycle. EMBO J., 11, 3053-3058.

Kimpton, J., and Emerman, M.

(1992) Detection of replication competent and pseudotyped HIV with a sensitive cell line on the basis of activation of an integrated ß-galactosidase gene. J. Virol., 66, 2232-2239.

Peden, K., Emerman, M., and Montagnier, L.

(1991) Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1/LAI, HIV-1/MAL, and HIV-1/ELI. Virology, 185, 661-672.

Selected publications 1984-1989

Emerman, M., Vazeux, R., and Peden, K.

(1989) The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization. Cell, 57 , 1155-1165.

Cordonnier, A., Montagnier, L., and Emerman, M.

(1989) Single amino acid changes in the human immunodeficiency virus envelope affect viral tropism and receptor binding. Nature, 340, 571-574.

Guyader, M., Emerman, M., Sonigo, P., Clavel, F., Montagnier, L, and Alizon, M.

(1987) Genome organization and transactivation of the human immunodeficiency virus type 2. Nature, 326, 662-669.

Emerman, M., Guyader, M., Montagnier, L., Baltimore, D., and Muesing, M.A.

(1987) The specificity of the human immunodeficiency virus type 2 transactivator is different from that of the human immunodeficiency virus type 1. The EMBO J., 6, 3755-3760.

Emerman, M. and Temin, H.M.

(1986) Comparison of promoter suppression in avian and murine retrovirus vectors. Nuc. Acid Res. 14: 9381-9396.

Emerman, M. and Temin, H.M.

(1984) Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism. Cell 39: 459-467.

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