Papers from the Gottschling Lab

D. E. Gottschling

DNA repair: corrections in the golden years.
Curr Biol. 2006 Nov 21;16(22):R956-8
Abstract

R. G. Gardner, Z. W. Nelson & D. E. Gottschling

Ubp10/Dot4p Regulates the Persistence of Ubiquitinated Histone H2B: Distinct Roles in Telomeric Silencing and General Chromatin.
Mol Cell Biol. 2005 Jul;25(14):6123-39
Abstract  | Full Text

R. G. Gardner, Z. W. Nelson & D. E. Gottschling

Degradation-mediated protein quality control in the nucleus.
Cell. 120(6):803-15 (2005)
Abstract  | Full Text

E. Y. Xu, X. Bi, M. J. Holland, D. E. Gottschling & J. R. Broach

Mutations in the Nucleosome Core Enhance Transcriptional Silencing.
Mol Cell Biol. 25(5):1846-59 (2005)
Abstract  | Full Text

D. E. Gottschling

Summary: epigenetics--from phenomenon to field.
Cold Spring Harb Symp Quant Biol. 2004;69:507-19

M. A. McMurray & D. E. Gottschling

Genetic instability in aging yeast: a metastable hyperrecombinational state.
Cold Spring Harb Symp Quant Biol. 2004;69:339-47

M. A. McMurray & D. E. Gottschling

Aging and genetic instability in yeast.
Curr Opin Microbiol 7(6):673-9 (2004)
Abstract  | Full Text

A. E. Stellwagen, Z. W. Haimberger, J. R. Veatch & D. E. Gottschling

Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.
Genes Dev 17(19):2384-2395 (2003)
Abstract  | Full Text

M. A. McMurray & D. E. Gottschling

An age-induced switch to a hyper-recombinational state.
Science 301(5641):1908-11 (2003)
Abstract  | Full Text

C. M. Smith, P. R. Gafken, Z. Zhang, D. E. Gottschling, J. B. Smith & D. L. Smith

Mass spectrometric quantification of acetylation at specific lysines within the amino-terminal tail of histone H4.
Anal Biochem 316(1):23-33 (2003)
Abstract  | Full Text

F. van Leeuwen & D. E. Gottschling

The histone minority report: the variant shall not be silenced.
Cell 112(5):591-3 (2003)
Abstract  | Full Text

F. van Leeuwen & D. E. Gottschling

Genome-wide histone modifications: gaining specificity by preventing promiscuity.
Curr Opin Cell Biol 14(6):756-62 (2002)
Abstract  | Full Text

C. M. Smith, Z. W. Haimberger, C. O. Johnson, A. J. Wolf, P. R. Gafken, Z. Zhang, M. R. Parthun, & D. E. Gottschling

Heritable chromatin structure: mapping "memory" in histones H3 and H4.
Proc Natl Acad Sci U S A 99 Suppl 4:16454-61 (2002)
Abstract  | Full Text

M. L. DuBois, Z. W. Haimberger, M. W. McIntosh, & D. E. Gottschling

A Quantitative Assay for Telomere Protection in Saccharomyces cerevisiae.
Genetics 161:995-1013 (2002)
Abstract  | Full Text

F. van Leeuwen & D. E. Gottschling

Assays for gene silencing in yeast.
Methods Enzymol 350:165-86 (2002)

F. van Leeuwen, P. R. Gafken, & D. E. Gottschling

Dot1p modulates silencing in yeast by methylation of the nucleosome core.
Cell 109(6):745-56 (2002)
Abstract  | Full Text

A. Bedalov, T. Gatbonton, W. P. Irvine, D. E. Gottschling, & J. A. Simon

Identification of a small molecule inhibitor of Sir2p.
Proc Natl Acad Sci U S A 98(26):15113-15118 (2001)
Abstract  | Full Text

S. J. Diede & D. E. Gottschling

Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere.
Current Biology 11(17):1336-40 (2001)
Abstract  | Full Text

S. E. Peterson, A. E. Stellwagen, S. J. Diede, M. S. Singer, Z. W. Haimberger, C. O. Johnson, M. Tzoneva, & D. E. Gottschling

The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.
Nature Genetics 27(1): 64-67 (2001)
Abstract  | Full Text

D. E. Gottschling

Gene silencing: Two faces of SIR2.
Current Biology 10: R708-R711 (2000)
Abstract  | Full Text

M. L. Dubois, S. J. Diede, A. E. Stellwagen, & D. E. Gottschling

All things must end: Telomere dynamics in yeast.
Cold Spring Harbor Symposia on Quantitative Biology 65:281-296 (2000)

T. J. Kelly, S. Qin, D. E. Gottschling, & M. R. Parthun

Type B Histone Acetyltransferase Hat1p Participates in Telomeric Silencing.
Mol Cell Biol 20: 7051-7058 (2000)
Abstract  | Full Text

S. J. Diede & D. E. Gottschling

Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.
Cell 99(7), 723-33 (1999)
Abstract  | Full Text

A. Kahana & D. E. Gottschling

DOT4 links silencing and cell growth in Saccharomyces cerevisiae.
Mol Cell Biol 19(10), 6608-6620 (1999)
Abstract  | Full Text

D. E. Gottschling & B. Stoddard

Telomeres: structure of a chromosome's aglet.
Current Biology 9(5), R164-7 (1999)
Abstract  | Full Text

J. B. Stevenson & D. E. Gottschling

Telomeric chromatin modulates replication timing near chromosome ends.
Genes Dev 13, 146-151 (1999)
Abstract  | Full Text

M. S. Singer, A. Kahana, A. J. Wolf, L. L. Meisinger, S. E. Peterson, C. Goggin, M. Mahowald, & D. E. Gottschling

Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae.
Genetics 150, 613-632, (1998)
Abstract  | Full Text

M. R. Parthun, J. Widom & D. E. Gottschling

The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism.
Cell 87, 85-94 (1996)
Abstract  | Full Text

M. S. Singer & D. E. Gottschling

TLC1: template RNA component of Saccharomyces cerevisiae telomerase [see comments].
Science 266, 404-409 (1994)
Abstract

O. M. Aparicio & D. E. Gottschling

Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way.
Genes Dev 8, 1133-1146 (1994)
Abstract

H. Renauld, O. M. Aparicio, P. D. Zierath, B. L. Billington, S. K. Chhablani & D. E. Gottschling

Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage.
Genes Dev 7, 1133-45 (1993)
Abstract

D. E. Gottschling

Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo.
Proc Natl Acad Sci U S A 89, 4062-5 (1992)
Abstract

O. M. Aparicio, B. L. Billington & D. E. Gottschling

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.
Cell 66, 1279-87 (1991)
Abstract

D. E. Gottschling, O. M. Aparicio, B. L. Billington & V. A. Zakian

Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription.
Cell 63, 751-62 (1990)
Abstract