Welcome to the
Parkhurst Lab Home Page

You have found the home page of Susan Parkhurst's Laboratory in the Division of Basic Sciences at Fred Hutchinson Cancer Research Center in Seattle, WA. Our lab is interested in the actions of both maternally and zygotically contributed gene products that govern proper embryonic development in Drosophila. We use developmental, genetic, cell and molecular approaches to look at different regulatory mechanisms and pathways required for proper Drosophila embryonic development. Our current efforts are divided between two areas of study: (1) the molecular mechanism(s) of transcriptional repression mediated by the hairy basic-Helix-Loop-Helix transcriptional regulator, and (2) actin cytoskeletal dynamics mediated by the Rho1 small GTPase.

Rho GTPases and Morphogenesis		Hairy and Transcriptional Repression