Genes and Proteins Related to SHIP

The oculocerebrorenal (OCRL) gene product. The SHIP2 protein.

  • The Ship2 gene product is the most closely related to Ship and was originally isolated as a partial cDNA called 51C, which lacked the SH2 domain. The full-length protein contains one potential PTB-binding site and three poly-proline regions and does contain an N-terminal SH2 domain. The sequence for the cDNA and protein can be obtained at murine SHIP2 or human SHIP2.

The human inositol polyphosphate-5-phosphatase type II gene product.

  • Most of the homology with Ship resides in the central IP5P-like domain, and like the OCRL protein, this gene product contains neither an SH2 domain, a PTB-binding site, nor potential SH3-binding sites. The sequence is found at M74161.

Synaptojanin.

  • A nerve terminal protein of 145 kDa, this protein is a member of the inositol-5 phosphatase family and contains several proline-rich sequences in the C-terminus. Synaptojanin may be involved in synaptic vesicle recycling and the sequence is found at rat synaptojanin.


5pt_Yeast_1-3

  • There are three known yeast inositol-5 phosphatases. These proteins are related to p150Ship in the central IP5P domain only and contain a SacI domain unrelated to the Ship protein within the N-terminal half of each yeast molecule. The sequences are listed in GenBank as: Z38062, Z47047, and X79743, and can be obtained using the GenBank database query at the bottom of our home page.


SIP proteins

  • Human cDNAs for two presumptive proteins of 145 kDA and 110 kDa have been reported and a third 130 kDa protein is inferred from these sequences. Unfortunately, there are several problems with these results because neither of the two cDNAs is complete and no RNA or protein data are presented. It is not even clear where the proteins are expressed because each cDNA was obtained from a different tissue. The GenBank description for U50040 (SIP-110), and U50041(SIP-145).