 |
|
|
|
|
|
|
|
|
|
|
 |
||||||||||
 |
 |
 |
||||||||
 |
||||||||||
 |
 |
 |
 |
 |
 |
 |
 |
 |
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||
|
|
|
|
||||||||
|
|
||||||||||
|
|
|
|
|
|
|
|
|
|
||
 |
| The domain structure of p145 SHIP. The SH2, inositol 5'-phosphatase, and C-terminal domains are shown in light orange, blue, and green, respectively. The region between the SH2 and inositol 5'-phosphatase domains is of unknown function and colored gray. Two asterisks above the central enzymatic domain mark the locations of homology regions with all 5'-phosphatases; and two NPXY motifs, when tyrosine phosphorylated, have potential for binding PTB or possibly SH2 domains. These are designated with red in the C-terminal region. The remainder of the C-terminal domain has several potential polyproline motifs (PxxP) for binding SH3 domains. These polyproline motifs are shown in dark green. Three of the motifs show very good consensus for SH3 domain binding, while two others have weaker homology and are shown with narrower dark green bands. The scale below the SHIP domain structure designates its length in amino acids. |
| The SHIP proteins are becoming a complex array of spliced products, and also may consist of a protein product expressed from separate promoters within the gene for SHIP. Several homologues and orthologues are known. The structural and biological properties of the SHIP proteins are therefore complex and will not be discussed indetail here. Most of these topics have been covered in the review: Rohrschneider, Fuller, Wolf, Liu and Lucas, Structure, Function, and Biology of the SHIP proteins.Genes & Development14:505-520,2000. |
| 1) References on SHIP. | This PubMed search is based on a set of keywords such as inositol phosphatase, SH2 domain, plus Ship -- beginning with publications in 1996. If only the keyword "Ship" is used, a gezillion references about "Diarrhea outbreak aboard a cruise Ship" are returned!! |
| 2)Related Genes.
|
This page lists a number of proteins related to SHIP along with their GenBank accession numbers. A more complete list is found in the above G & D review publication. |
| 3) SHIP Humor Page. |  See how weird a few scientists can be.
|
 |
 |
 |
 |
 |
 |