Simon Lab at the FHCRC

Yeast Screen of FDA-Approved Anticancer Drugs and Related Compounds

These data have not been endorsed by the National Cancer Institute or the Fred Hutchinson Cancer Research Center.
  • A general overview of the project.
  • Description of the experimental procedures used in the yeast screen.
  • Table of the yeast strains used in the drug screen.
  • Complete list of the FDA-approved, non-biological anticancer drugs.
  • Summary of selective toxicities in the yeast screen of FDA-approved anticancer drugs.

  • Irradiation

    X-rays

  • Alkylating Agents

    Lomustine (NSC-79037)
    Carmustine (NSC-409962)
    Streptozocin (NSC-85998)
    Cisplatin (NSC-119875)
    Mechlorethamine (NSC-762)
    Mitomycin (NSC-26980)
    Thiotepa (NSC-6396)
    Dacarbazine (NSC-45388)

  • Antimetabolites

    Methotrexate (NSC-740)
    Trimetrexate (NSC-249008)
    Ara-CMP (NSC-99445)
    Fludarabine phosphate (NSC-312887)
    Hydroxyurea (NSC-32065)
    Fluorouracil (NSC-19893)
    Floxuridine (NSC-27640)
    Pentostatin (NSC-218321)

  • DNA cutters

    Bleomycin (NSC-125066)

    Topoisomerase I poisons

    Camptothecin sodium salt (NSC-100880)

    Topoisomerase II poisons

    Daunorubicin (NSC-82151)
    Doxorubicin (NSC-123127)
    Idarubicin (NSC-256439)
    Mitoxantrone (NSC-301739)

  • DNA binders

    Dactinomycin (NSC-3053)
    Send comments and questions to Julian Simon.


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