Simon Lab at the FHCRC

List of FDA-Approved Non-biological Anticancer Drugs

These data have not been endorsed by the National Cancer Institute or the Fred Hutchinson Cancer Research Center.

This is a listing of all chemical agents approved for the treatment of cancer. The compounds have been divided into the traditional categories according to mechanism of action or structural similarities. The highlighted drugs have been tested in the Field Station's Yeast Screen. These results can be viewed by following the link.

Alkylating Agents

Nitrosourea-related Compounds

Lomustine (NSC-79037)
Carmustine (NSC-409962)
Streptozocin (NSC-85998)

Mustards

Mechlorethamine (NSC-762)
Melphalan (NSC-8806)
Uracil Nitrogen Mustard (NSC-34462)
Chlorambucil (NSC-3088)
Cyclophosphamide (NSC-26271)
Iphosphamide (NSC-109724)

Other Alkylating Agents

Cisplatin (NSC-119875)
Carboplatin (NSC-2412240)
Mitomycin (NSC-26980)
Thiotepa (NSC-6396)
Dacarbazin (NSC-45388)
Procarbazine (NSC-77213)
Hexamethyl Melamine (NSC-13875)
Triethylene Melamine (NSC-9706)
Busulfan (NSC-750)
Pipobroman (NSC-25154)
Mitotane (NSC-38721)

Antimetabolites

Methotrexate (NSC-740)
Trimetrexate (NSC-249008), a Methotrexate analog
Pentostatin (NSC-218321)
Cytarabine (NSC-63878)
Ara-CMP (NSC-99445), an activated form of Cytarabine
Fludarabine phosphate (NSC-312887)
Hydroxyurea (NSC-32065)
Fluorouracil (NSC-19893)
Floxuridine (NSC-27640)
Chlorodeoxyadenosine (NSC-105014)
Gemcitabine (NSC-613327)
Thioguanine (NSC-752)
6-Mercaptopurine (NSC-755)

DNA cutters

Bleomycin (NSC-125066)

Topoisomerase I poisons

Topotecan (NSC-609699)
Irinotecan (NSC-616348)
Camptothecin sodium salt (NSC-100880), a strucutral analog of Topotecan and Irinotecan

Topoisomerase II poisons

Daunorubicin (NSC-82151)
Doxorubicin (NSC-123127)
Idarubicin (NSC-256439)
Mitoxantrone (NSC-301739)
Teniposide (NSC-122819)
Etoposide (NSC-141540)

DNA binders

Dactinomycin (NSC-3053)
Mithramycin (NSC-24599)

Spindle Poisons

Vinblastine (NSC-49842)
Vincristine (NSC-67574)
Navelbine (NSC-608210)
Paclitaxel (NSC-125973)
Docetaxel (NSC-628503)

Some brief thoughts on the generally accepted mechanism of action for the FDA-approved drugs.

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Send comments and questions to Julian Simon.