Most recent papers:
Stolworthy, T.S., Korkegian, A. M., Willmon, C. L., Ardiani, A., Cundiff, J., Stoddard, B. L. and Black, M.E.  (2008) "Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine" J. Mol. Biol 377 (3): 854 - 869.
and

Jiang, L, Althoff, E. A., Clemente, F. R., Doyle, L., Rothlisberger, D., Zanghellini, A., Gallaher, J. L., Betker, J. L., Tanaka, F., Barbas, C. F., Hilvert, D., Houk, K. N., Stoddard, B. L. and Baker, D. (2008) "De Novo computational design of retro-aldol enzymes" Science 319 : 1387 - 1391.
and

Lambert, A. R., Sussman, D., Shen, B. W., Nix, J., Maunus, R., Samuelson, J., Xu, S. -Y., and Stoddard, B. L. (2008) "Structures of the rare cutting restriction endonuclease NotI revieal a novel metal binding fold involved in DNA recognition" Structure 16: 558 - 569.   (See also this commentary)    (Supplementary Information)

 Intron-encoded homing endonucleases, maturases and REases
  Blood coagulation proteins  General enzymology / Time-resolved
 Nucleotide synthesis and salvage
 
  Hydrolases, phosphatases, kinases  Protein Engineering Reviews and Commentaries

Articles, 1993 to present (click on top heading of each group to go to research summary page):

Intron-encoded homing endonucleases, maturases and restriction endonucleases:

1. Stephens, K., Monnat, R. Heath, P.J. and Stoddard, B. L. (1997) "Crystallization and preliminary x-ray characterization of I-CreI: an intron-encoded restriction endonuclease" Proteins 28: 137 - 139.

2. Heath, P. J., Stephens, K., Monnat, R. and Stoddard, B. L. (1997) "Structure of the I-CreI intron-encoded endonuclease: a novel fold that binds and cleaves a long DNA target sequence" Nature Structural Biology 4 (6) 468-476.

3. Flick, K.E., McHugh, D., Heath, J.D., Stephens, K.M., Monnat, R.J. Jr., and Stoddard, B.L. (1997) "Crystallization and preliminary X-ray studies of I-PpoI: a nuclear, intron-encoded homing endonuclease from Physarum polycephalum" Protein Science 6: 2677 - 2680.

4. Flick, K.E., Jurica, M. S., Monnat, R. J. Jr., and Stoddard, B. L. (1998) "DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI" Nature 394: 96 - 101.

5. Jurica, M. S., Monnat, R. J. Jr. and Stoddard, B. L. (1998) "DNA recognition and cleavage by the LAGLIDADG homing endonuclease I-CreI" Molecular Cell 2: 469 - 476.

6. Galburt, E., Chevalier, B., Tang, W., Jurica, M. S., Flick, K. E., Monnat, R. J. Jr., and Stoddard, B. L. (1999) "A novel endonuclease mechanism directly visualized for I-PpoI" Nature Structural Biology 6: 1096 - 1099.

7. Galburt, E., Jurica, M., Chevalier, B., Erho, D., Tang, W., Monnat, R. J. Jr., and Stoddard, B. L. (2000) "Conformational changes and cleavage by the homing endonuclease I-PpoI: a critical role for a leucine residue in the active site" J. Mol. Biol. 300(4): 877 - 887.

8. Chevalier, B., Monnat, R. J. Jr. and Stoddard, B. L. (2001) "The homing endonuclease I-CreI uses three metals, one of which is shared between two active sites" Nature Structural Biology 8 (4): 312 - 316. 

9. Chevalier, B., Kortemme, T., Chadsey, M., Baker, D., Monnat, R. J. Jr. and Stoddard, B. L. (2002) "Design, activity and structure of a highly specific artificial endonuclease" Molecular Cell 10 : 895 - 905. (Also listed under "protein engineering" below)

10. Chevalier, B., Turmel, M., Lemieux, C., Monnat, R. J. Jr. and Stoddard, B. L. (2003) "Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI" J. Mol. Biol. 329: 253 - 269.

11. Bolduc, J. M., Spiegel, P. C., Chatterjee, P., Brady, K. L., Downing, M. EW., Caprara, M. G., Waring, R. B. and Stoddard, B. L. (2003) "Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor" Genes and Development 17: 2875-2888.
(See also the corresponding commentary by Marlene Belfort)

12.  Bakhrat, A., Jurica, M. S., Stoddard, B. L. and Raveh, D. (2004) "Homology modeling and mutational analysis of HO endonuclease of yeast" Genetics 166: 721 - 728.

13.   Shen, B. W., Landthaler, M., Shub, D. A. and Stoddard, B. L.  (2004) "DNA binding and cleavage by the HNH homing endonuclease I-HmuI" J. Mol. Biol. 342 (1): 34 - 56..

14.  Sussman, D., Chadsey, M., Fauce, S., Engel, A., Bruett, A., Monnat, R. J. Jr., Stoddard, B. L. and Seligman, L. (2004) "Isolation and characterization of new homing endonuclease specificities at individual target site positions" J. Mol. Biol. 342 (1): 31 - 41.

15.  Chevalier, B., Sussman, D., Otis, C., Noel, A. -J., Turmel, M., Lemieux, C., Stephens, K., Monnat, R. J. Jr. and Stoddard, B. L.  (2004) "Analysis of the symmetric metal-dependent I-CreI homing endonuclease mechanism" Biochemistry  43: 14015 - 14026.

16.  Landthaler, M., Shen, B.W., Stoddard, B. L. and Shub, D.A.  (2006) "Two phage intron-encoded endonucleases with homologous DNA recognition sequences but distinct DNA specificities" J. Mol. Biol. 358 (4): 1137 - 1151.

17.  Ashworth, J., Havranek, J. J., Duarte, C. M., Sussman, D., Monnat, R. J. Jr., Stoddard, B. L. and Baker, D. (2006) "Computational redesign of endonuclease DNA binding and cleavage specificity" Nature Nature 441: 656 - 659..  (Also listed under "protein engineering" below)    (Also see this news and views by Carl Pabo)

18.  Spiegel, P. C., Chevalier, B., Sussman, D., Turmel, M., Lemieux, and Stoddard, B. L. (2006) "The structure of I-CeuI homing endonuclease: evolving asymmetric DNA recognition from a symmetric protein scaffold" Structure 14 (5): 869 - 880.    (Also see this commentary by Fred Gimble)

19.  Rosen, L. E., Morrison, H. A., Masri, S., Brown, M. J., Springstubb, B., Sussman, D., Stoddard, B. L. and Seligman, L. M. (2006) "Homing endonuclease I-CreI derivatives with novel DNA target specificities" Nuc. Acids Research 34 (17): 4791 - 800.

20.  Zhao, L, Boncora, R., Shub, D. and Stoddard, B. L. “The restriction folds turns to the dark side: a bacterial homing endonuclease with a PD(D/E)XK motif” (2007) EMBO Journal 26: 2432 - 2442.    (Zhao et al. supplementary information)

21.  Volna, P., Jarjour, J., Baxter,S., Roffler, S. R., Monnat, R. J. Jr., Stoddard, B. L. and Scharenberg, A. M. (2007) "Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases" Nucleic Acids Research 35 (8): 2748 - 2758.  (Volna et al. supplementary information)

22.  Eastberg, J., Monnat, R. J. Jr., and Stoddard, B. L. (2007) “Mutability of the ββα-metal HNH nuclease active site: substitution of a deprotonation mechanism” Biochemistry 46 (24): 7215 - 7225.

23.  Scalley-Kim, M., McConnell-Smith, A. and Stoddard, B. L. (2007) "Coevolution of homing endonuclease specificity and its host target sequence" J. Mol. Biol. 372 (5): 1305 - 1319.   (plus Supplementary Information).

24.  Eastberg, J. H., McConnell-Smith, A., Zhao, L., Ashworth, J., Shen, B. W. and Stoddard, B. L. (2007) "The thermodynamics of DNA target site recognition by homing endonucleases" Nuc. Acids Res. 35 (21) 7209 - 7221.

25.  Lambert, A. R., Sussman, D., Shen, B. W., Nix, J., Maunus, R., Samuelson, J., Xu, S. -Y., and Stoddard, B. L. (2008) "Structures of the rare cutting restriction endonuclease NotI revieal a novel metal binding fold involved in DNA recognition" Structure 16: 558 - 569.   (See also this commentary)    (Supplementary Information)

Hydrolases, Phosphatases and Kinases:

1.  Galburt, E., Pelletier, J., Wilson G., and Stoddard, B. L. (2002) "Structure of a tRNA repair enzyme and molecular biology workhorse, T4 polynucleotide kinase"Structure10 (9): 1249 - 1260.

2.  Perraud, A. -L., Shen, B., Dunn, C. A., Rippe, K., Smith, M. K., Bessman, M. J., Stoddard, B. L. and Scharenberg, A. M. (2003) "NUDT9, a member of the nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase" J. Biol. Chem. 278 (3): 1794 - 1801. 

3.  Shen, B. W., Perraud, A. -L., Scharenberg, A. M and Stoddard, B. L. (2003) "The crystal structure and mutational analysis of human  NUDT9" J. Mol. Biol. 332(2):385-98.

4.  Eastberg, J., Pelletier, J., and Stoddard, B. L. (2004) "Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase"Nucleic Acids Research 32 (2): 653 - 660.

5.  Perraud., A. -L., Takanishi, C., Shen, B. W., Kang, S., Smith, M. K., Schmitz, C., Knowles, H. M., Ferraris, D., Li, Weixing, Zhang, J., Stoddard, B. L. and Scharenberg, A. M. (2005) "Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels" J. Biol. Chem. 280 (7): 6138 - 6148.

Blood coagulation factors:

1. Pratt, K. P., Shen, B. W., Takeshima, K., Davie, E. W., Fujikawa, K. and Stoddard, B. L. (1999) "Structure of the C2 domain of human factor VIII at 1.5 angstrom resolution"Nature 402: 439 - 442.

2. Liu, M., Shen, B. W., Nakaya, S., Pratt, K. P., Fujikawa, K., Davie, E. W., Stoddard, B. L., and Thompson, A. R. (2000) "Hemophilic factor VIII C1 and C2 domain missense mutations and their modeling to the 1.5 angstrom human C2 domain crystal structure" Blood 96(3): 979 - 987.

3. Spiegel, P. C., Jacquemin, M., St. Remy, J. -M., Stoddard, B. L. and Pratt, K. P. (2001) "Structure of a factor VIII C2 domain/IgG4K Fab complex: identification of an inhibitory antibody epitope on the surface of Factor VIII" Blood 98(1): 13 - 19 (Plenary Article).

4.  Spiegel, P.C., Kaiser, S. M., Simon, J. and Stoddard, B. L. (2004) "Disruption of protein-membrane binding and identification of small molecule inhibitors of coagulation factor VIII" Chemistry and Biology 11 (10): 1413 - 1422.

5.  Spiegel, P. C. and Stoddard, B. L. (2004)  "Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities" J. Biol. Chem. 279 (51): 53691 - 53698. 

6.  Shen, B. W., Spiegel, P.C., Chang, C. -H., Huh, J. -W., Lee, J. -S., Kim, J., Kim, Y. -H. and Stoddard, B. L. (2008) "Tertiary structure and domain organization of coagulation factor VIII" Blood 111 (3): 1240 - 1247.

 

General mechanistic enzymology:

1. Lee, M., Klein, O. D., Bolduc, J., Dyer, D. H., Stoddard, B. L. and Koshland, D. E. Jr. (1995) "The role of the catalytic residues Lysine 230 and Tyrosine 160 in the NADP+-dependent isocitrate dehyrogenase" Biochemistry 34: 378 - 384.

2. Bolduc, J., Dyer, D., Lee, M., Scott, W. G., Singer, P., Sweet, R. M., Koshland, D. E. Jr. and Stoddard, B. L. (1995) "Mutagenesis and laue structures of enzyme intermediates: isocitrate dehydrogenase" Science 268: 1312 - 1318.

3. Stoddard, B. L. and Farber, G. K. (1995) "Direct measurement of steady-state kinetic constants in the enzyme crystal" Structure 3: 991 - 996.

4. O'Hara, P., Goodwin, P. and Stoddard, B. L. (1995) "Determination of substrate diffusion rates in protein crystals by optical microspectrophotometry using CCD video analysis" J. Appl. Cryst. 28: 829 - 833.

5. Brubaker, M., Dyer, D. H., Stoddard, B. L. and Koshland, D. E. Jr. (1995) "Synthesis and characterization of caged isocitrate: a photolytic trigger for enzyme catalysis" (1996) Biochemistry 35: 2854 - 2864.

6. Stoddard, B. L., Dean, A. and Bash, P. A. (1996) "Combining Laue diffraction and molecular dynamics to study enzyme intermediates: formation of a Michaelis complex" Nature Struct. Biol. 3 (7): 590 - 594.

7. Scott, W. G., Stoddard, B. L. and Klug, A. (1996) "Capturing structures of catalytic RNA intermediates: the hammerhead ribozyme" Science 274: 2065 - 2069.

8. Mesecar, A., Stoddard, B. L. and Koshland, D. E. Jr. (1997) "Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences" Science 277: 202 - 206.

9. Cohen, B. E., Stoddard, B. L. and Koshland, D. E. Jr. (1997) "Caged NADP and NAD. Synthesis and characterization of functionally distinct caged compounds. " Biochemistry 36: 9035 - 9044.

10. Stoddard, B. L., Cohen, B., Brubaker, M., Mesecar, A. and Koshland, D. E. Jr. (1998) "Millisecond Laue structures of an enzyme product complex using photocaged substrate analogues" Nature Structural Biology 5 (10): 891 - 897.

11. Jurica, M. S., Heath, P. J., Shi, W., Mesecar, A., and Stoddard, B. L. (1998) "The allosteric regulation of pyruvate kinase by fructose-1,6-bis-phosphate" Structure 6 (2) 195 - 210.

12. Bryant, M. D., Flick, K. E., Koduri, R. S., Wilton, D. C., Stoddard, B. L., and Gelb, M. H. (1999) "1,3-dioxane-4,6-dione-5-carboxamide-based inhibitors of human group IIA phospholipase A2: X-ray structure of the complex and interfacial selection of inhibitors from a structural library" Bioorg. & Med. Chem. Letters 9: 1097 - 1102.

13. Bond, C. J., Huang, J. -Y., Hajduk, R., Heath, P. J., Flick, K. E., and Stoddard, B. L. (2000) "Cloning, sequence and crystallographic structure of recombinant iron superoxide dismutase from Pseudomonas ovalis" Acta Cryst D56 1359 - 1366.

14. Bond, C., Jurica, M. S., Mesecar, A. and Stoddard, B. L. (2000) "Determinants of allosteric activation of yeast pyruvate kinase and identification of novel effectors using computational screening" Biochemistry 39: 15333 - 15343 .

15.  Cotton, N. J., Stoddard, B. L. and Parson, W. W. (2004) "Oxidative inhibition of soluble human catechol-o-methyltransferase" J. Biol. Chem. 279: 23710 - 23718.
 

Nucleoside synthesis and salvage enzymes:

1. D'Ari, L., Cheung, E., Rabinowitz, J., Bolduc, J. and Stoddard, B. L. (1997) "Purification, crystallization, and preliminary x-ray Data for 10-formyl-tetrahydrofolate synthetase from Clostridium acidi-urici" Proteins 27: 319 - 321.

2. Cheung, E., D'Ari, L., Rabinowitz, J. C., Dyer, D. H. and Stoddard, B. L. (1997) "Purification, crystallization, and preliminary x-ray studies of a bifunctional 5,10-methenyl/methylene tetrahydrofolate cyclohydrolase/dehydrogenase from Escherichia coli" Proteins 27: 322 - 324.

3. Shen, B. W., Dyer, D. H., Huang, J. -Y., D'Ari, L., Rabinowitz, J., and Stoddard, B. L. (1998) "The crystal structure of a bacterial bifunctional 5,10-methylene tetrahydrofolate cyclohydrolase/dehydrogenase" Protein Science 8(6) 1342 - 1349.

4. Ireton, G., Black, M., and Stoddard, B. L. (2001) "Crystallization and prelminary X-ray analysis of bacterial cytosine deaminase" Acta Cryst D 57: 1643 - 1645.

5. Ireton, G., McDermitt, G., Black, M. and Stoddard, B. L. (2002) "The structure of Escherichia coli cytosine deaminase" J. Mol. Biol. 315(4): 687 - 697.

6. Ireton, G., Black, M. and Stoddard, B. L. (2003) "The 1.14 Å crystal structure of yeast cytosine deaminase:  evolution of nucleotide salvage enzymes and implications for genetic chemotherapy" Structure 11(8): 961 - 972.

7.  Ireton, G. and Stoddard, B. L. (2004) "Microseed matrix screening to improve crystals of yeast cytosine deaminase" Acta Cryst D 60: 601 - 605.

8.  Mahan, S. D., Ireton, G. C., Stoddard, B. L. and Black, M. E. (2004) "Alanine-Scanning Mutagenesis Reveals a Cytosine Deaminase Mutant with Altered Substrate Preference" Biochemistry 43: 8957 - 8964.

9.  Mahan, S. D., Ireton, G. C., Stoddard, B. L. and Black, M. E. (2004) “Directed evolution and selection of bacterial cytosine deaminase with altered substrate specificity towards 5-fluorocytosine”  Protein Engineering and Design 17 (8): 225 – 633. (Also listed under "protein engineering" below)

10.  Korkegian, A., Baker, D. and Stoddard, B. L. (2005) "Computational thermostabilization of an enzyme catalyst" Science 308: 857 - 860 (Also listed under "protein engineering" below).

11.  Stolworthy, T.S., Korkegian, A. M., Willmon, C. L., Ardiani, A., Cundiff, J., Stoddard, B. L. and Black, M.E.  (2008) "Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine" J. Mol. Biol 377 (3): 854 - 869.

Protein Engineering:

(Please note that some of these papers are also listed under their respective biological functions, above)


1.  Chevalier, B., Kortemme, T., Chadsey, M., Baker, D., Monnat, R. J. Jr. and Stoddard, B. L. (2002) "Design, activity and structure of a highly specific artificial endonuclease" Molecular Cell 10 : 895 - 905 (Also listed under "intron-encoded proteins" above).

2.  Kuhlman, B., Dantas, G., Ireton, G. C., Varani, G., Stoddard, B. L. and Baker, D. (2003) "Design of a novel globular protein fold with atomic accuracy" Science 302:1364 - 1368.   (See also the corresponding commentary in the same issue)

3.  Kortemme, T., Joachimiak, L. A., Bullock, A. N., Stoddard, B. L. and Baker, D. (2004) "Computational redesign of protein-protein interaction specificity" Nature Structural and Molecular Biology 11: 371 - 379.

4.  Mahan, S. D., Ireton, G. C., Stoddard, B. L. and Black, M. E. (2004) “Directed evolution and selection of bacterial cytosine deaminase with altered substrate specificity towards 5-fluorocytosine”  Protein Engineering and Design 17 (8): 225 – 633. (Also listed under "nucleotide synthesis and salvage enzymes" above).

5.  Korkegian, A., Baker, D. and Stoddard, B. L. (2005) "Computational thermostabilization of an enzyme catalyst" Science 308: 857 - 860 (Also listed under "nucleotide synthesis and salvage enzymes" above).

6.  Ashworth, J., Havranek, J. J., Duarte, C. M., Sussman, D., Monnat, R. J. Jr., Stoddard, B. L. and Baker, D. (2006) "Computational redesign of endonuclease DNA binding and cleavage specificity" Nature Nature 441: 656 - 659. (Also listed under "intron-encoded proteins" above)

7.  Joachimiak, L.A., Kortemme, T., Stoddard, B. L., and Baker, D. (2006) "Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface" J. Mol. Biol. 361 (1): 195-208.

8.  Dantas, G., Watters, A.L., Lunde, B. M., Eletr, Z. M., Isern, N.G., Roseman, T., Lipfert, J., Doniach, S., Tompa, M., Kuhlman, B., Stoddard, B. L., Varani, G. and Baker, D. (2006) "Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution" J. Mol. Biol. 362 (5): 1004 - 1024.

9.  Jiang, L, Althoff, E. A., Clemente, F. R., Doyle, L., Rothlisberger, D., Zanghellini, A., Gallaher, J. L., Betker, J. L., Tanaka, F., Barbas, C. F., Hilvert, D., Houk, K. N., Stoddard, B. L. and Baker, D. (2008) "De Novo computational design of retro-aldol enzymes" Science 319 : 1387 - 1391.

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Reviews, Summaries and Commentaries:

1. Stoddard, B. L., Farber, G. K., and Strong, R. K. (1993) "Facts and Fancy of Microgravity Protein Crystallization" Biotechnology and Genetic Engineering Reviews 11: 57 - 77.

2. Stoddard, B. L. (1996) "Laue diffraction: potential for enzyme mechanism and inhibitor screening" Pharmacology and Therapeutics 70 (3): 215 - 256.

3. Stoddard, B. L. (1996) "Caught in a chemical trap" Nature Structural Biology 3 (11): 907 - 909.

4. Flick, K. E. and Stoddard, B. L. (1996) "Calcineurin" Current Opinions in Structural Biology 6 (6) 770 - 775.

5. Ellman, J., Stoddard, B. L. and Wells, J. (1997) "Combinatorial Thinking in Chemistry and Biology" PNAS USA 94: 2779 - 2782.

6. Stoddard, B. L. and Pietrokovski, S. (1998) "Breaking up is hard to do" Nature Structural Biology 5 (1): 3 - 6.

7. Jurica, M. S. and Stoddard, B. L. (1998) "Mind your Bs and Rs: Bacterial Chemotaxis, signal transduction, and protein recognition" Structure 6: 809 - 813.

8. Stoddard, B. L. (1998) "New results from time-resolved crystallography" Curr. Opin. Struct. Biol. 8: 612 - 618.

9. Stoddard, B. L., Bolduc, J. M., Dyer, D. H., Scott, W. G. and Sweet, R.M. (1998) "Visualizing enzyme and ribozyme intermediates using fast diffraction and reaction trapping methods" Pure and Applied Chemistry 70 (1): 17 - 23.

10. Jurica, M. S. and Stoddard, B. L. (1999) "Homing endonucleases: structure, function and evolution" Cellular and Molecular Life Sciences 55: 1304 - 1326.

11. Gottschling, D. and Stoddard, B. L. (1999) "Telomeres: Structure of a chromosome's aglet" Current Biology 9: R164 - R167. ]

12. Ren, Z., Bourgeois, D., Helliwell, J. R., Moffat, K., Srajer, V. and Stoddard, B. L. (1999) "Laue Crystallography: Coming of Age" Journal of Synchrotron Radiation 6: 891 - 917.

13. Galburt, E. and Stoddard, B. L. (2000) "Restriction endonucleases: one of these things is not like the others" Nature Structural Biology 7(2): 89 - 91.

14. Stoddard, B. L. (2001) "Accumulation and trapping of catalytic intermediates for crystallographic structure determination" Methods 24: 125 - 138.

15. Galburt, E., and Stoddard, B. L. (2001) "Time-resolved macromolecular crystallography" Physics Today July: pg. 33 - 39.

16. Chevalier, B. and Stoddard, B. L. (2001) "Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility" Nucleic Acids Research 28(18): 3757-3774. 

17.  Spiegel, P. C. and Stoddard, B. L. (2002) "Optimization of factor VIII replacement therapy: can structural studies help evade antibody inhibitors?" British Journal of Haematology 119: 310 - 322. 

18.  Galburt, E. and Stoddard, B. L. (2002) "The catalytic mechanisms of restriction and homing endonucleases" Biochemistry 41 (47): 13851 - 13860.

19.  Roberts, R., et al., Stoddard, B. L. et al. (2003) "A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes" Nucl. Acids. Res. 31 (7): 1805 - 1812.

20.  Chevalier, B., Monnat, R. J. Jr. and Stoddard, B. L. (2005) "The LAGLIDADG homing endonuclease family" in Homing endonucleases and Inteins (Springer Verlag; M. Belfort, V. Derbyshire, D. Wood and B. Stoddard, editors) .

21.  Stoddard, B. L. (2005) "Homing endonuclease structure and function" Quarterly Reviews in Biophysics (January issue; published online Dec. 2005).

22.  Monnat, R. J. Jr., Scharenberg, A. M. and Stoddard, B. L. (2008) "Progress in engineering homing endonucleases for gene targeting: ten years after structures "  Progress in Gene Therapy Volume 3: Autologous and cancer stem cell gene therapy (R. Bertolotti and K. Ozawa, ed.) World Scientific Publishers.