Brett Chevalier

(Graduate Student, 1997 - 2002)

Division of Basic Sciences
Program in Structural Biology
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N.
Seattle, WA 98109
and
Graduate Program in Molecular and Cellular Biology
University of Washington and Fred Hutchinson Cancer Research Center
Seattle, WA

Current Contact Information:

chevalib@gmail.com



Galburt, E., Chevalier, B., Tang, W., Jurica, M. S., Flick, K. E., Monnat, R. J. Jr., and Stoddard, B. L. (1999) "A novel endonuclease mechanism directly visualized for I-PpoI" Nature Structural Biology 6: 1096 - 1099.

Galburt, E., Jurica, M., Chevalier, B., Erho, D., Tang, W., Monnat, R. J. Jr., and Stoddard, B. L. (2000) " Conformational changes and cleavage by the homing endonuclease I-PpoI: a critical role for a leucine residue in the active site" J. Mol. Biol. 300 (4): 877 - 887.

Chevalier, B., Monnat, R. J. Jr. and Stoddard, B. L. (2001) " The homing endonuclease I-CreI uses three metals, one of which is shared between two active sites" Nature Structural Biology 8 (4): 312 - 316. 

Chevalier, B. and Stoddard, B. L. (2001) "Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility" Nucleic Acids Research 28(18): 3757-3774.  

Chevalier, B., Kortemme, T., Chadsey, M., Baker, D., Monnat, R. J. Jr. and Stoddard, B. L. (2002) " Design, activity and structure of a highly specific artificial endonuclease " Molecular Cell 10 : 895 - 905.

Chevalier, B., Turmel, M., Lemieux, C., Monnat, R. J. Jr. and Stoddard, B. L. (2003) "Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-Cre I and I-MsoI" J. Mol. Biol. 329: 253 - 269.

Chevalier, B., Sussman, D., Otis, C., Noel, A. -J., Turmel, M., Lemieux, C., Stephens, K., Monnat, R. J. Jr. and Stoddard, B. L.  (2004) "Analysis of the symmetric metal-dependent I-CreI homing endonuclease mechanism" Biochemistry  43: 14015 - 14026.

Spiegel, P. C., Chevalier, B., Sussman, D., Turmel, M., Lemieux, and Stoddard, B. L. (2006) "The structure of I-CeuI homing endonuclease: evolving asymmetric DNA recognition from a symmetric protein scaffold" Structure 14 (5): 869 - 880.  


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