Research has shown that certain vegetables can increase the activity of groups of enzymes (called glutathione-S-transferases or GST for short) that help our body get rid of potentially harmful substances, including carcinogens. Genetic differences among individuals can play a role in how effectively these cancer-fighting enzymes work. The GUSTO study will look at how the interplay of genes and diet – in particular, a diet rich in vegetables – may affect the function of the body’s cancer-fighting enzymes. The results of this study, funded by the National Cancer Institute, could be important in making recommendations about diets that prevent cancer.
About 600 people are sought for the first part of the study, screening for genetic patterns of enzymes. People will be asked to provide some cheek cells by swishing and spitting mouthwash into a container. DNA will be extracted from these cells and analyzed for genetic patterns of enzymes.
Out of that group, 72 people, ages 20 to 40, who have specific genetic patterns of enzymes will be asked to participate. The feeding study, conducted in four 14-day feeding periods, will look at the influence of a diet high in vegetables on the function of these cancer-fighting enzymes. The Hutchinson Center will provide all food and beverages during each feeding study period.
For more information, contact Yvonne Schwarz
