Identification and Validation of Circulating Biomarkers of the Early Detection of Breast Cancer in Pre-clinical Specimens

PI: Christopher Li PhD

The specific aims of this study are: 1) To use three proteomic platforms to identify protein biomarkers in preclinical sera that could potentially be used for the early detection of breast cancer; 2) To validate the utility of the potential protein biomarkers identified in this study with respect to their specificity and sensitivity as markers of early detection; and 3) To enhance the predictive power of our set of protein biomarkers by including known risk factors for breast cancer in our models.