Postdoctoral Fellows

2007/2008

Tanya Day, PhD (VGH) is a graduate of Flinders University and Medical Centre in South Australia, where she completed her PhD in the Department of Hematology and Genetic Pathology. Her work on chromosomal inversion response in the prostate after low dose radiation exposure has led to eight publications, five of which as first or last author. She joined Dr. Martin Gleave's team in late 2006. Her work involves the identification and characterization of expression and biological functions associated with newly identified isoforms and splice variants of human clusterin. She is currently working to identify functions and regulation of expression of a newly identified, pro-apoptotic, clusterin splice variant. Since joining the Prostate Centre, she has submitted an invited book chapter for a book entitled "Androgen Action in Prostate Cancer" (Chapter ref: Day, T.K., Nelson, C.C. & Gleave, M.E. Differential Regulation of Clusterin Isoforms by the Androgen Receptor).
Mentor: Martin Gleave

Liesel M. FitzGerald, PhD (FHCRC) received her PhD in Molecular Genetics from the University of Tasmania, Australia in 2007. The focus of Dr. FitzGerald's work is in familial genetics and genetic epidemiology with a focus on the field of prostate cancer. She joined the SPORE Career Development program as a post-doctoral fellow to be mentored by Dr. Janet Stanford in November, 2007. She will be working with Dr. Stanford on the genetic epidemiology of hereditary and sporadic prostate cancer.
Mentor: Janet L. Stanford

Boris Hadaschik, PhD (VGH) joined the Prostate Centre in 2006 as a Post-doctoral Fellow. He is currently working on preclinical proof-of-principle studies for a new compound called HTI-286 which is being tested both against prostate and bladder cancer. He has established and validated an orthotopic bladder cancer model in mice using in vivo bioluminescent imaging and within this model system he is currently evaluating mucoadhesive cytotoxic agents, oncolytic viruses and antisense oligonucleotides as intravesical agents against nonmuscle-invasive bladder cancer. He is collaborating with Dr. Raymond Andersen (Earth and Ocean Sciences, UBC) and Dr. Helen Burt (Pharmaceutical Sciences, UBC) on some of these projects. Once his fellowship is complete, Dr. Hadaschik will return to Mainz, Germany in June 2008 to finish his residency in Urology.
Mentor: Martin Gleave

Sarah K. Holt, PhD received her PhD in Epidemiology from the University of Washington in Seattle in 2006. The focus of Dr. Holt's work is in genetic epidemiology, and she has an interest in the field of prostate cancer. She joined the SPORE Career Development program as a post-doctoral fellow to be mentored by Dr. Janet Stanford in September, 2006. She will be working with Drs. Stanford, Lin, and Ostrander on genetic epidemiology of hereditary and sporadic prostate cancer.
Mentor: Janet Stanford

Dapei Li, PhD (FHCRC) received his PhD in Pharmacology, and joined the SPORE Career Development program as a post-doctoral fellow working with Dr. Peter Nelson in 2006. His current SPORE project is titled "Exploiting Prostate Cell Type-Specific Gene Expression Mechanisms for Diagnostic and Therapeutic Applications." He has focused on developing panels of markers capable of identifying and isolating cell types within the prostate that exibit distinct molecular phentoypes. The application of this work toward characterizing subtypes of disseminated or circulating prostate cancer cells is currently being explored as an adjunct to clinical trials involving surgical and pharmacological therapies. This work is being carried out in collaboration with Dr. Larry True.

Jonathan Wright, MD (UW) came to the University of Washington for residency with impeccable credentials (e.g., Phi Beta Kappa, AOA). During his resident research year he got a Masters in Public Health. He will begin as an oncology fellow in 2007, taking one or two research years before completing his clinical fellowship. He is an outstanding individual with an impressive curriculum vitae for his stage of development and is totally dedicated to a career in academia focused on CaP research.
Mentor: Janet Stanford

Amina Zoubeidi, PhD began working as a post-doctoral fellow in Dr. Gleave's laboratory in January 2005. She is working on mechanisms of molecular chaperones in prostate cancer progression. Specifically, she is working on: 1) the role of Hsp27 in ligand dependent and independent androgen receptor activation; 2) the role of Hsp27 in IGF signaling; and, 3) the molecular basis of clusterin in prostate cancer cell survival. Some of her results are published (e.g. Zoubeidi A, Zardan A, Beraldi E, Fazli L, Sowery R, Rennie P, Nelson C, Gleave M. "Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity." Cancer Research 2007. Nov 1;67(21):10455-65) and others and 3 others have been submitted or are near completion. She has also presented abstracts in posters in more than 16 national and international conferences. Dr. Zoubeidi was recognized as having one of the top abstracts at the ASCO prostate cancer meeting (San Francisco), 2006. In 2007, she received awards from the Canadian Prostate Cancer Research Initiative, the NorthWest Urological Society and the AACR-Women in Cancer Research Brigid G. Leventhal Scholar in Cancer Research Award.
Mentor: Martin Gleave

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