Graduate Students

Courses offered at Fred Hutchinson

Conj 512 
How To Give A Scientific Seminar (1.5 Credits)
Winter 13 — Weeks 1-5

Location: FHCRC, Day Campus; Weintraub Bldg., Rm. B1-076
Meeting Time: Tues & Thurs, 3:20 to 4:40p
Organizers: *Sue Biggins (FHCRC), Katie Peichel (FHCRC)

This course will provide training for MCB graduate students to effectively give a scientific seminar about their research. At the end of the class, students will have prepared and practiced a complete seminar and received feedback from their peers and the instructors.

*For more information about the course contact Sue Biggins, (206) 667-1351

Conj 512 Course Syllabus

Conj 529 
Cell Migration (1.5 Credits)
Winter 14 — Weeks 6-10

Location: FHCRC, Day Campus; Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizers: *Cecilia Moens (FHCRC/UW Biology & BMSD Affiliate), Jon Cooper (FHCRC/UW Biochemistry Affiliate)

This course will explore mechanisms of cell migration in vivo and in cell culture. We will discuss the cell biology of different forms of cell migration, the extracellular cues that direct migration and how these cues are integrated by the migrating cell.

*For more information about the course contact Cecilia Moens, (206) 667-5627

Conj 529 Course website

Conj 533  
The Dynamic Chromosome
(1.5 Credits)
Autumn 12 — Weeks 1-5

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizer: Sue Biggins (FHCRC)

This course is a graduate level introduction to the chromosome, viewing it as the ultimate organelle. Topics this year will focus on the functions and evolution of chromosomal elements as well as the mechanisms that ensure the maintenance and propagation of chromosomes. The class will use a combination of lecture, literature review, and in class discussion to explore genetic, biochemical, and cytological methods for defining our current knowledge about chromosomes. The course requires students to have taken undergraduate cell biology, biochemistry and genetics. Active participation in discussion is required.

*For more information about the course contact Sue Biggins, (206) 667-1351

Conj 533 Course website

Conj 537
Mechanisms of Transcriptional Regulation (1.5 Credits)
Autumn 12 - Weeks 6-10

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizer: Toshio Tsukiyama (FHCRC/UW Biochemistry Affiliate)

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Transcriptional regulation, development and diseases in mammals (Steve Tapscott).

For more information about the course contact Toshio Tsukiyama, (206) 667-4996

Conj 537 Course Syllabus

MCB 539 
Biological Basis of Neoplasia (3 Credits)
Spring 13

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructors: Valeri Vasioukhin, Toshiyasu Taniguchi, (FHCRC/UW Pathology Affiliates)

This course allows students to gain experience in applying the several disciplines which comprise cellular and molecular biology toward a deeper understanding of a complex biological problem: neoplastic change. The course consists of a series of lectures and discussion meetings to introduce students to the major themes in research in the cellular and molecular biology of neoplastic change. They cover principal molecular mechanisms responsible for tumor initiation and progression, with a specific emphasis on DNA repair mechanisms, cell cycle checkpoints and loss of normal tissue homeostasis. The latest state of the art research in  Cancer Biology will be presented by invited scientists experts in their relevant field.  The discussion meetings will concentrate on selected major papers in cancer biology and be presented and discussed by the students with help and guidance of the instructors.  

Student overall participation, activity during discussions, quality and depth of the research paper presentation, and the written research proposal on one of the topics in cancer biology will be used for course credit and grading.

Prerequisites: Introductory biochemistry and cell biology.

For more information contact: Toshiyasu Taniguchi or Valeri Vasioukhin, (206) 667-1710

MCB 539 Course website

Conj 544 
Protein Structure, Modification and Regulation (1.5 Credits)
Winter 14 — Weeks 1-5

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructors: Roland K. Strong (FHCRC/UW Immunology Affiliate)
Readings: Selected papers from primary literature.

We will provide an overview of general principles of protein structure, including (i) forces and interactions that contribute to folding, dynamics and stability, (ii) the structural and functional effects of post-transcriptional and post-translational splice variation, (iii) covalent chemical modification of protein side chains, (iv) the functional effects of ligand binding via cooperativity and allostery, and and (v) diversification of protein fold and function during evolution.

Background and Prerequisites: The course will assume knowledge at the level of an advanced undergraduate biochemistry course. Knowledge in the areas we will discuss at the level of Stryer Biochemistry or Alberts Molecular Biology of the Cell will be assumed.

For More Information and Course Overview

Conj 551 
Immunity (1.5 Credits)
Periodically

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/74
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructor: Roland K. Strong (FHCRC/UW Immunology Affiliate)
Readings: Selected chapters from Abbas & Lichtman, Cellular & Molecular Immunology, 5th edition, and papers from the primary literature.

The goal of this course is to provide an understanding of the workings of the central cellular and molecular players in the mammalian immune system, at a level appropriate for the non-specializing graduate student. Classes will be run as discussions of the assigned readings. The selective topics will include the molecular basis of B and T cell activation and effector functions, as well as an introduction to the mechanisms of innate immunity. The course grade will be based upon written critiques and in-class oral presentations of seminal papers from the current and classic literature.

Prerequisites: A basic understanding of molecular biology and biochemistry from undergraduate- and prior graduate-level courses as well as permission of the instructor. Course size will be limited to ten (auditors are welcome).

For more information about the course contact Roland Strong, (206) 667-5587.

Conj 551 Course website

Conj 552
Metabolic Flexibility in Biology
(1.5 Credits)
Fall 13 — Weeks 1-5

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-072/74
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructors: Dan Gottschling (FHCRC/UW Genome Sciences Affiliate), Mark Roth (FHCRC/UW Biochemistry Affiliate)

This course will focus on small molecules and the ways that the chemistry of these molecules facilitates life under changing conditions. It will include systems from microbiology to human physiology to understand aspects of cancer, aging, and animation. A combination of lecture and in class discussion will be used to explore topics including bioenergetics/metabolic flux, adaptation, and allometric scaling.

Prerequisites: Undergraduate organic chemistry and biochemistry. Evaluations will be made based on assigned problem sets. Graduate students only. No auditors. Course limited to 25 students.

Conj 552 Course website

Genetics

MCB / FHCRC 517 Topics
DNA Repair and Genetic Recombination
(3 Credits)
Gerry Smith

This course emphasizes the critical analysis of data, using DNA repair and recombination as an example. The goals are to help students critically analyze scientific literature, to introduce them to a current subject in molecular and cellular biology, and to aid them in public presentations. The instructor will give short lectures for background, followed by detailed discussion of one to three papers from classical and current literature. Weekly problem sets are assigned. Periodically; Thursday mornings for 3 hours.

For more information contact Gerry Smith, (206) 667-4438.

Development

MCB/FHCRC 521  
Embryos, Genes & Development (3 credits)
James Priess* and Cecilia Moens

This course introduces vertebrate and invertebrate development, emphasizing cellular, genetic and molecular mechanisms. The course will focus on development of the model organisms zebra fish, fruit flies, and nematodes. Emphasis will be on understanding fundamental embryological processes such as induction, determination, and pattern formation. Current technologies available for each system will be described, such as the construction of transgenic animals, genetics, mosaic analysis, homologous recombination, and classical embryonic manipulations. Selected topics include developmental genetics of regulatory hierarchies, lateral inhibition, and cell lineage analysis. Following introductory lectures, the course will focus on primary literature detailing the current state of the field using journal club presentations (by students). Winter 13/14

A basic knowledge of principles of molecular and cellular biology is assumed for the course.

*For more information about course contact: Jim Priess or (206) 667-2871

Virology

MCB / FHCRC 532  
Human Pathogenic Viruses (3 Credits)
Michael Emerman

This course will cover the molecular biology and pathogenesis of major groups of human viruses, including retroviruses, flaviviruses, herpesviruses, influenza viruses, poliovirus, papillomaviruses, and others. The class will meet on Tuesdays and Thursdays from 1:30 to 3:00 PM.; FHCRC Rooms B1-072 & 074. Course registration is limited to 24. Fall 12/13

For more information contact Michael Emerman, (206) 667-5058.

MCB 532 Course website

MCB / FHCRC 533 
Evolutionary Genetics and Genomics (3 Credits)
*K. Peichel and H. Malik

An understanding of evolutionary processes is becoming increasingly important in biomedical research. The purpose of this elective is to introduce graduate students with backgrounds in molecular, cellular, and developmental biology to evolutionary approaches. A combination of lectures, discussions of primary literature, and "hands-on" assignments to provide training in comparative and genomic approaches will be used during the course. Tuesdays and Thursdays from 1:30 to 3:00 PM.; FHCRC Rooms B1-072 & 074. Course registration is limited to 15. Fall 13/14

*For more information contact Katie Peichel, (206) 667-1628

MCB 540
Nucleic Acid Enzymes
(1.5 Credits)
Winter 13 - Weeks 1-5
B. L. Stoddard

In this class, we survey a wide variety of enzymatic process that control the structure and modification of DNA and RNA, with particular focus on structure, function and mechanism.  Unifying features of major reaction types (such as phosphoryl transfers and base modifications) will constitute core material.
Tuesdays and Thursdays at 3:20-4:40p, FHCRC Day Campus, Weintraub Bldg, Rm B1-072/074.

For more info, please contact Barry Stoddard at (206) 667-4031.

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