Cancer Prevention Program

Population Architecture using Genomics and Epidemiology (PAGE)

This program is designed to study the “epidemiological architecture” of established GWAS findings in diverse and well characterized cohorts. The focus of this research is to investigate if genetic variants initially identified through GWAS research are a) generalizing across ancestral groups,  b) modified by environmental factors (gene-environment interactions) and c) associated with various outcomes (pleiotropy).  PAGE is studying a variety of outcomes, including cardiovascular diseases, stroke, obesity, diabetes, insulin glucose, inflammation, lipids, cancer reproductive history, ECG phenotypes among others. PAGE is conducting candidate SNP genotyping of GWAS findings as well as comprehensive fine-mapping of GWAS regions to aid the identification of underlying functional variants.  Drs. Kooperberg and Peters co-lead the Women’s Health Initiative efforts of PAGE.

More information can be found here: https://www.pagestudy.org/

PAGE includes the following studies with a total of over 400,000 participants:

  • Causal Variants Across the Life Course (CaliCo) Consortium:
    • Atherosclerosis Risk In Communities (ARIC),
    • Coronary Artery Risk In Young Adults (CARDIA),
    • Cardiovascular Heart Study (CHS),
    • Hispanic Community Health Study,
    • Strong Heart Cohort Study,
    • Strong Heart Family Study
  • Epidemiologic Architecture of Genes Linked to Environment (EAGLE)
  • Multiethnic Cohort
  • Women’s Health Initiative

Efforts are coordinated through the PAGE Coordinating Center at Rutgers University and University of Southern California

For questions or additional information please contact:

Charles Kooperberg, PhD
Full Member
Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N
M3-A410
PO Box 19024
Seattle, WA 98109-1024
Phone: (206) 667 4142
Email: clk@fhcrc.org

Ulrike (Riki) Peters, PhD, MPH
Associate Member
Fred Hutchinson Cancer Research Center
Research Associate Prof University of Washington
PO Box 19024
1100 Fairview Avenue N, M4-B402
Seattle, WA 98109-1024
Phone: (206) 667-2450
Email: upeters@fhcrc.org

Fred Hutchinson Cancer Research Center is a world leader in research to prevent, detect and treat cancer and other life-threatening diseases.