Science Projects

  • A Multi-State Study of Cancer Treatment and Outcomes Among American Indians
    Public Health Sciences
  • A Study of Cancer Diagnosis as a Risk Factor for Personal Bankruptcy
    Public Health Sciences
  • Adipose Tissue Inflammation in the Etiology of Obesity-associated Chronic Disease
    Public Health Sciences
  • Advancing Innovative Comparative Effectiveness in Cancer Diagnostics (ADVICE)
    Public Health Sciences
  • Advancing Our Understanding of the Etiologies and Mutational Landscapes of Basal-like Luminal A, and Luminal B Breast Cancers
    Public Health Sciences
  • Affinity Based Serum Proteomics: Breast and Ovarian Cancer
    Public Health Sciences
  • Affinity Based Strategies to Fast Track Development of Colon Cancer Biomarkers
    Public Health Sciences
  • Asia Cohort Consortium
    Public Health Sciences
    The Asia Cohort Consortium (ACC) is a collaborative effort seeking to understand the relationship between genetics, environmental exposures, and the etiology of disease through the establishment of a cohort of at least one million healthy people around the world.
  • Aspirin, UGT1A6 Genotype, and Colon Gene Expression study ("ABC, Aspirin and the Biology of the Colon")
    Public Health Sciences
  • Association Between HIV and Survival after Cancer Diagnosis
    Public Health Sciences
  • Bai Lab
    Basic Sciences
  • Bedalov Lab
    Clinical Research
    The Bedalov Lab conducts research to identify drugs that disrupt gene silencing, a process that has been implicated in cancer and other diseases in which genes are inappropriately shut off.
  • Bernstein Lab
    Clinical Research
    Dr. Irwin D. Bernstein's research interests include normal and leukemic hematopoietic stem cells, antibody targeted therapies for lymphoma and leukemia, and the biology of acute myeloid leukemia.
  • Beronja Lab
    Human Biology
    Regulation of epithelial growth in development and cancer. Tissue growth is a fundamental biological process that generates functional organs in development, and maintains them in the adulthood through continuous cycles of renewal and repair.
  • Bielas Lab
    Public Health Sciences
    The Bielas Lab studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the development of cancer and age-related disease. Translational research projects explore the potential utility of these mutations as novel DNA biomarkers for improved disease detection, treatment outcome, survival and quality of life.
  • Biggins Lab
    Basic Sciences
    The Biggins Lab uses budding yeast to study chromosome segregation, the process by which chromosomes are distributed to new cells during cell division. Cells with an abnormal number of chromosomes are a hallmark of cancer and many birth defects.
  • Biobehavioral Sciences
    Clinical Research
    The Biobehavioral Sciences program investigates mechanisms and methods for integrating behavioral and biological components of care for cancer survivors during and following active treatment.
  • Biomarkers For Ovarian Cancer Diagnosis and Screening
    Public Health Sciences
  • Biomarkers Lab
    Public Health Sciences
  • Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non-progressing Cancers
    Public Health Sciences
  • Biostatistics and Biomathematics Program
    Public Health Sciences
  • Bloom Lab
    Basic Sciences
    The Bloom lab uses a combination of experimental and computational approaches to study the molecular evolution of proteins and viruses. A major goal is to understand the underlying biophysical and immunological constraints that shape influenza evolution.
  • Boeckh Lab
    Vaccine and Infectious Disease
    The long-term goal of the Boeckh Research Program is to prevent infectious disease in immunocompromised hosts and reduce the severity of infections that do occur. We focus on herpes viruses (primarily cytomegalovirus), respiratory viruses, and the genetics of susceptibility to infection.
  • Bolouri Lab
    Human Biology
    The Bolouri Lab is interested in understanding how gene regulatory interactions control cellular state and identity, particularly during development (e.g. in stem cells). The lab specializes in the development and use of computational systems biology methods to map gene regulatory networks.
  • Bradley Lab
    Basic Sciences
    The Bradley Lab uses genomics and molecular genetics to study alternative splicing, the process by which a single gene can give rise to multiple, distinct protein isoforms. Alternative splicing enormously increases the complexity of eukaryotic genomes, and plays important roles in many human diseases.
  • BRAVO Study
    Public Health Sciences
    The purpose of the BRAVO Study is to understand what causes different types of breast cancer. It will include women who have experienced breast cancer, from age 20 to age 69, living in Washington state and New Mexico.
  • Breast Cancer and HRT: Genetic Susceptibility within the Progesterone Pathway
    Public Health Sciences
  • Breast Cancer Research Program
  • Breast Cancer Risk and Molecular Change After Chernobyl
    Public Health Sciences
    This study has two primary aims: 1) to investigate whether the risk of premenopausal breast cancer is associated with individual radiation dose to the breast from the Chernobyl accident, to estimate the risk per unit dose, to investigate the shape of the dose- response, and potential dose effect modifying factors, including molecular characteristics and established breast cancer risk factors; and 2) to investigate whether the association of breast cancer risk with radiation exposure differs according to characteristics of breast cancer, including hormone receptor status, genomic loss and gain, and specific alterations in 14 selected DMA repair genes.
  • Breast Health Global Initiative
    Public Health Sciences
    The Breast Health Global Initiative (BHGI), co-sponsored by Fred Hutchinson Cancer Research Center and Susan G. Komen for the Cure®, pioneered development of comprehensive resource-sensitive, evidence based clinical Guidelines for International Breast Health and Cancer Control to improve breast cancer outcomes in low- and middle-resource countries (LMCs) through the collaboration of an alliance of dedicated organizations and individuals.
  • Breeden Lab
    Basic Sciences
    The Breeden Lab investigates control of cell division in budding yeast, with a long-term goal of understanding how the commitment to the mitotic cell cycle is regulated in response to environmental and internal cues.
  • Brent Lab
    Basic Sciences
    The Brent Lab studies how living cells sense, represent, transmit and act upon information to make decisions about their future states. The lab includes, experimentally, a social science component, in which lab members are encouraged to identify and analyze how their research outcomes and ongoing increases in biological knowledge might impact human affairs.
  • Buck Lab
    Basic Sciences
    The Buck lab studies the mechanisms and neural circuits that underlie the sense of smell and pheromone sensing in mammals. They are also interested in aging.
  • C-erbB-2 and Risk of Contralateral Breast Cancer
    Public Health Sciences
    This Career Development Award expands Dr. Li's previous work on contralateral breast cancer (CBC).
  • Cadmium Exposure and Risk of Breast Cancer in the Women’s Health Initiative
    Public Health Sciences
  • Cancer Biology Program
    Public Health Sciences
    The Cancer Biology Program, which was formed in 1991, is comprised of seven laboratories that provide opportunities for new research directions that complement and benefit from the epidemiology and cancer prevention components of the Public Health Sciences Division.
  • Cancer Epidemiology Research Cooperative (CERC)
    Public Health Sciences
    Our studies focus on the causes of cancer, cancer prevention, factors associated with cancer survival, and the effects of cancer on the quality of life.
  • Cancer Information for Uganda
  • Cancer Prevention Program
    Public Health Sciences
  • Cancer Surveillance System
    Public Health Sciences
    The Cancer Surveillance System (CSS) collects population-based data on cancer incidence and survival in 13 counties in western Washington State. These cancer data are collected to provide public health scientists and practitioners with the ability to track trends in the incidence of all forms of cancer (surveillance); identify and investigate patterns of cancer occurrence (epidemiology); and monitor of trends in mortality and survival for specific cancers (end results).
  • Cancer Survivorship: decreasing the risk of colon cancer mortality
    Public Health Sciences
  • CANTRANce
  • CAREGEN: Genetic susceptibility and the risk of breast cancer
    Public Health Sciences
    This is an ancillary study of the NICHD Women’s CARE Study, a large population-based multi-center case-control study among Caucasian and African-American women that is designed primarily to evaluate the risk of breast cancer in women ages 35-64 in relation to oral contraceptive (OC) use and hormone replacement therapy (HRT).
  • Carlson Group
    Public Health Sciences
    The Carlson Group uses genetic epidemiology to investigate the genetic risk factors of diseases such as cancer, cardiovascular and neurological disease. The group identifies statistical correlations between variations and disease. The group's molecular biology laboratory is then equipped to assess the molecular mechanisms behind these correlations. Recently, the lab has played a significant role in development of technologies for adaptive immune system profiling, in collaboration with Harlan Robins and Hootie Warren. These tools are being applied to a variety of arenas.
  • Carotene and Retinol Efficacy Trial (CARET)
    Public Health Sciences
  • Ceballos Studies
    Public Health Sciences
  • Center for Biological Futures
    Basic Sciences
  • Center for Comparative Effectiveness Research in Cancer Genomics (CANCERGEN)
    Public Health Sciences
  • Center for Hispanic Health Promotion: Reducing Cancer Disparities
    Public Health Sciences
  • Center for Sustainable Health
  • Center for the Evaluation of Biomarkers for the Early Detection of Breast Cancer
    Public Health Sciences
  • Characterization of the Gut Bacteria involved in Isoflavone and Estrogen Metabolism
    Public Health Sciences
  • Chen Lab
    Public Health Sciences
    The Chu Chen Lab is conducting a hospital-based study to discover biomarkers that may improve diagnosis and prognosis of oral cancer. Several other studies focus on the links between genetic and environmental factors and development of, and/or survival from, tobacco-related and hormone-related cancers.
  • Clurman Lab
    Clinical Research
    The Clurman Lab studies how cell division is regulated in normal cells, and how abnormal control of cell division leads to cancer. They hope to use these mechanistic insights into tumor formation to develop new cancer treatment strategies.
  • Cocoa Flavanols and Multivitamin Supplements
    Public Health Sciences
    The Women’s Health Initiative will be conducting a five-year, large-scale randomized controlled trial to test the effect of a concentrated cocoa extract and multivitamin supplements in reducing risks of CVD and cancer.
  • ColoCare Consortium
    Public Health Sciences
  • Colon Cancer Pathways: Hyperplastic Polyps & Adenomas
    Public Health Sciences
  • COMIDAS Study
    Public Health Sciences
    The COMIDAS study will compare the metabolic response between traditional Mexican diets vs. Western diets.
  • COMIDAS Study – Project 2 in Understanding and Preventing Breast Cancer Disparities in Latinas
    Public Health Sciences
  • Comprehensive Center for the Advancement of Scientific Strategies (COMPASS)
    Public Health Sciences
  • Computational Biology
    Public Health Sciences
    Members of the Computational Biology Program use and develop novel computational methods, often in combination with wet-laboratory experiments, to investigate biological mechanisms across a broad range of topics.
  • Cooper Lab
    Basic Sciences
    The Cooper Lab investigates proteins involved in the signaling pathways that allow cells to communicate with each other. In particular, they study a protein called Disabled and the Src protein family to better understand how they regulate normal cell behavior and the transformation of normal cells to cancer cells.
  • CORE Family Studies
    Public Health Sciences
    This international registry provides a comprehensive infrastructure for facilitating interdisciplinary studies in the genetic epidemiology of colorectal cancer
  • Crohn's Allogeneic Transplant Study (CATS)
    Clinical Research
    A clinical study for treatment of patients with severe Crohn's Disease, using bone marrow transplantation. This study is being conducted by Dr. George McDonald and teams of doctors and nurses at the University of Washington Medical Center, Seattle Children's Hospital and the Fred Hutchinson Cancer Research Center in Seattle.
  • Cx43 Phosphorylation Modulates Kras Mediated Pancreas Cancer Progression
    Public Health Sciences
  • DEEM Study - Investigating the Role of a Lifestyle Intervention on Novel Estrogen Biomarkers
    Public Health Sciences
    The specific impact of diet and exercise relating to the prevention of cancer remains unclear. Help us examine the impact of improved nutritional and physical activity habits on reactive estrogens.
  • defeatHIV, the Delaney Cell and Genome Engineering Initiative
    Clinical Research, Vaccine and Infectious Disease
    Led by the Hutchinson Center's Drs. Keith Jerome and Hans-Peter Kiem, the Delaney Cell and Genome Engineering Initiative, also known as defeatHIV, is a consortium of FHCRC and external investigators working together to eradicate HIV. Their research efforts utilize the latest cellular and genetic engineering techniques to develop HIV-resistant cells and to target and incapacitate HIV within the host.
  • Delaney Lab
    Clinical Research
  • Depo-Provera and Breast Cancer: Epidemiology and Pathology
    Public Health Sciences
    The primary objective of this study is to assess the relationship between DMPA use and breast cancer risk among young women in a large population-based study.
  • Descriptive Epidemiology and Clinical Course of Myelodysplastic Syndromes (MDS) within the Group Health Cooperative
    Public Health Sciences
    An epidemiologic study using patient databases from the Group Health Cooperative to estimate basic descriptive statistics for myelodysplastic syndromes (MDS) (e.g., incidence, prevalence, survival) and to track patterns of treatment for the disease.
  • Diagnostic and Biomarkers Statistical (DABS) Center
    Public Health Sciences
  • Diet and Diet-Related Factors in the PCPT
    Public Health Sciences
  • Diet and genetic risk for prostate cancer (Results from Carotene and Retinol Efficacy Trial = CARET)
    Public Health Sciences
  • Diet and Systemic Inflammation Study
    Public Health Sciences
  • Disparities Projects
  • DNA Repair, Folate, and Colorectal Carcinogenesis
    Public Health Sciences
    A study to investigate the relationship between genetic variability in enzymes related to DNA damage and repair of that damage
  • DOVE Study
    Public Health Sciences
    The purpose of the DOVE Study is to further our understanding of why some women develop ovarian tumors and others do not. The results of this study will help to improve the health of future generations of women.
  • Early Detection Research Network (EDRN)
    Public Health Sciences
  • Early Detection Research Network (EDRN) Breast and Ovary Cancer Clinical Validation Center
    Public Health Sciences
    Early Detection Research Network (EDRN), a multidisciplinary research team dedicated to discovering and validating candidate early detection biomarkers for breast and ovary cancers.
  • Edlefsen Group
    Vaccine and Infectious Disease
  • Eisenman Lab
    Basic Sciences
    The Eisenman Lab studies how cell proliferation, growth, and differentiation are regulated through the actions of transcriptional networks, and how this regulation is undermined during tumor progression. The lab employs the tools of molecular biology as well as mammalian and Drosophila genetics to study basic mechanisms underlying normal and abnormal cellular functions.
  • Elucidation of a Bacterial Cell Shape Generating Program
    Public Health Sciences
  • Emerman Lab
    Human Biology, Basic Sciences
    The Emerman Lab studies the molecular and evolutionary basis for the replication of HIV and related viruses, with an emphasis on the interaction of these viruses with their host cells. Their goal is to understand what determines resistance or vulnerability to current, past and potential viral diseases.
  • Energy Balance, Organochlorine Exposure, and Possible Toxicologic Effects
    Public Health Sciences
    The study builds on resources from an existing randomized controlled trial of exercise, with an extensive assessment of immune function biomarkers.
  • Epidemiology and Biostatistics Training
    Public Health Sciences
    Provide skills in epidemiology and biostatistics that will enable the trainee to address this problem through the conduct of high quality cancer research.
  • Epidemiology Program
    Public Health Sciences
  • Equol, Breast, and Bone Study
    Public Health Sciences
  • Etzioni Lab
    Public Health Sciences
    The Etzioni Lab focuses on statistical methods for prostate-cancer studies, with the goal of improving guidelines for screening and treatment. Etzioni has assessed the likely impact of prostate-specific antigen testing on prostate-cancer incidence and mortality, and developed approaches for evaluating new cancer-screening biomarkers.
  • Evaluation of a Hepatitis B Outreach Intervention for Cambodians
    Public Health Sciences
  • EXCEL Study
    Public Health Sciences
    The ExCel research study is a breast cancer prevention clinical trial. It is an important international clinical trial designed to determine whether a special type of medication can prevent breast cancer in healthy postmenopausal women who are at an increased risk for developing breast cancer.
  • Factors Affecting Survival of Young Breast Cancer Patients
    Public Health Sciences
    This study seeks to identify factors that affect the risk of recurrence and death in a cohort of 1400 women diagnosed with invasive breast cancer before age 45.
  • Feeding Study to Examine the Effect of Glycemic Load and Obesity on Cancer Biomarkers (CARBS / Seattle TREC Project 3)
    Public Health Sciences
  • Fero Lab
    Clinical Research
    The Fero Lab studies how cell-cycle regulatory genes, p27 and Rb, control growth of tumors and normal tissues. Using novel mouse models and genomic technologies, they have discovered that cell cycle inhibitors and microRNAs regulate T-cell growth and differentiation, whereas mutations of these genes cooperate in lymphoma development.
  • Flax FX Study
    Public Health Sciences
    Flaxseed and many nuts contain lignans. The "phytochemicals" are thought to be beneficial to health but it is not clear how they work. Help us research how flaxseed lignans affect the colon.
  • Fong Group
    Vaccine and Infectious Disease
    The Fong Group specializes in using biostatics and computer modeling to investigate complex biological problems, with an emphasis on vaccine development. The group��is working together with other Hutchinson Center researchers to evaluate immune responses to HIV vaccines, and to design and analyze HIV vaccine trials.
  • Fredricks Lab
    Vaccine and Infectious Disease
  • Galloway Lab
    Human Biology
    The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.
  • Geballe Lab
    Human Biology
    The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses.
  • Genetic Counseling for Participants of the Colon Cancer Family Registry – Seattle
    Public Health Sciences
  • Genetic Requirements of Helicobacter pylori Infection
    Public Health Sciences
  • Genetic Studies of Prostaglandin Synthesis/EGFR and Risk of Colorectal Neoplasia
    Public Health Sciences
  • Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)
    Public Health Sciences
  • Genome-Wide Association Study in Early-Onset Breast Cancer
    Public Health Sciences
    This study aims to conduct a genome-wide association study of young (less than 50 years) invasive female breast cancer to identify new genes responsible for young cases who are negative for BRCA1 and BRCA2 gene mutations.
  • Genome-Wide Association Study on Breast Cancer within the Women's Health Initiative
    Public Health Sciences
  • Geographic Clustering of Myelodysplastic Syndromes (MDS) and Correlation with Pollution Sources
    Public Health Sciences
    This study constitutes one of the first large population-based investigations of incidence patterns of myelodysplastic syndromes (MDS) in the United States.
  • Gilbert Group
    Vaccine and Infectious Disease
    Statistical design and analysis of HIV vaccine efficacy trials
  • Gottardo Lab
    Vaccine and Infectious Disease
    The Gottardo Lab conducts research in computational biology and statistical genomics with applications to high throughput biological assays and immunology.
  • Gottschling Lab
    Basic Sciences
    The Gottschling Lab uses budding yeast as a model system to investigate fundamental questions in biology. One of their current areas of research interest is the striking link between increasing age and cancer incidence in humans.
  • Grandori Lab
    Human Biology
    The Grandori Lab focuses on exploiting the weaknesses of cancer cells to identify targeted, less toxic cancer therapies. RNA interference (RNAi) combined with high throughput technology enables us to interrogate the human genome for genes that are essential for viability of molecularly defined cancer cells, thus allowing the unbiased identification of these Achilles' heels.
  • Green Group
    Clinical Research
  • Greenberg Lab
    Clinical Research
    The Greenberg Lab's guiding research goals are to understand the principles underlying T cell recognition of viruses and cancer cells, to determine why such responses often fail to eliminate the virus or cancer, and to develop cellular and molecular approaches that manipulate the immune system to treat human viral and malignant diseases.
  • Gut Microbiota and Colonic Gene Expression: A Lignan Trial in Humans
    Public Health Sciences
  • GVHD Assessment Video
    Clinical Research
  • GWAS, SNPs
    Public Health Sciences
  • Hahn Lab
    Basic Sciences
    The Hahn Lab studies the mechanism and regulation of transcription, the process of mRNA synthesis. Transcriptional regulation is one of the key steps controlling cell growth, differentiation and development, and defects cause many human illnesses. Using biochemistry, structural biology and molecular genetics, the lab focuses on the mechanism of the large conserved protein complexes that regulate and promote transcription.
  • Hansen Lab
    Clinical Research
    The Hansen Lab's primary research focus is graft-vs.-host disease (GVHD). Ongoing studies investigate whether monitoring of gene expression correlates with T-cell activation, programmed cell death, severity of GVHD, the patient���s response to primary therapy or treatment failure, and emergence of tolerance.
  • Health Disparities Research Center
    Public Health Sciences
  • Health Effects of Sugar-Sweetened Beverages Study
    Public Health Sciences
    Fred Hutchinson Cancer Research Center is recruiting adults 18-65 years old to participate in a study that will investigate the health effects of sugar-sweetened beverages.
  • Health, Eating, Activity, and Lifestyle (HEAL) Study
    Public Health Sciences
    A study to investigate methods to improve breast cancer survival
  • Heimfeld Lab
    Clinical Research
    The Heimfeld Lab focuses on the translation of new cell-based therapies from the scientist's bench to the patient's bedside. Areas of research include improvements in specific cell-subset selection, large-scale therapeutic-cell culturing in closed systems, optimized cryopreservation and cell storage.
  • Henikoff Lab
    Basic Sciences
    The Henikoff Lab studies the structure, function and evolution of chromosomes. They also develop tools for epigenomics and functional genomics.
  • Hepatitis B ESL Education for Chinese
    Public Health Sciences
  • Hockenbery Lab
    Clinical Research
    The Hockenbery lab studies programmed cell death (apoptosis) pathways that are defective in many cancer cells; and the role of cancer-cell metabolism in apoptosis, oncogene functions, and environmental/dietary risk factors, including excess supply of nutrients. After identifying cancer-selective targets, they carry out small-molecule screens for inhibitors to identify lead compounds as anticancer agents.
  • Holland Lab
    Human Biology
    The Holland lab works at the intersection of multiple disciplines to address the molecular basis of brain tumors and develop new approaches to their treatment. Our research focuses on developing mouse models of brain cancer that mimic the behavior of the disease in patients. Our work with mouse models has led to clinical trials in glioma patients. We also have developed imaging strategies to follow mouse brain tumors as they develop—a powerful system that is used to test promising new drugs with potential benefit for patients.
  • Hormones and Colon Cancer: Epigenetic Subtypes, Risk and Survival
    Public Health Sciences
  • HPV Vaccination in a Cambodian Community
    Public Health Sciences
  • Huang Lab
    Vaccine and Infectious Disease
    The Huang Lab focuses on the evaluation of biomarkers for disease prevention and control. The lab also studies genetic epidemiology, particularly the detection of gene-environment interactions based on genome-wide association studies and the construction of risk prediction models using the genetic regulatory network.
  • Human Gut Microflora Profiling Population Studies
    Public Health Sciences
  • Identification and Validation of Circulating Biomarkers for the Early Detection of Breast Cancer in Pre-clinical Specimens
    Public Health Sciences
    A study to use three proteomic platforms to identify protein biomarkers in preclinical sera that could potentially be used for the early detection of breast cancer.
  • Identification and Validation of Circulating Biomarkers of the Early Detection of Breast Cancer in Pre-clinical Specimens
    Public Health Sciences
    This study aims to are to use three proteomic platforms to identify protein biomarkers in preclinical sera that could potentially be used for the early detection of breast cancer.
  • Immune Exercise Study
    Public Health Sciences
  • Immune Function Studies
    Public Health Sciences
  • Improving Breast Cancer Screening at the Primary Care Level
    Public Health Sciences
  • INSIGHT Study
    Public Health Sciences
    The purpose of this study is to look for the possible causes of developing a second breast cancer among women who had an in situ breast cancer.
  • Institute for Prostate Cancer Research
    Clinical Research
    The institute is a collaborative effort of Fred Hutchinson Cancer Research Center and UW Medicine. A natural outgrowth of established research and clinical collaborations, the IPCR brings together a world-renowned team whose mission is to understand the causes of prostate cancer and its progression, develop new prevention strategies, devise innovative diagnostics and improve survival and quality of life.
  • Integrated Discovery of Novel Markers in Hodgkin Lymphoma
    Public Health Sciences
  • Integrated Sensor Technology for Real-Time Recording of Dietary Intake
    Public Health Sciences
  • IRIS Study
    Public Health Sciences
    The goal of the IRIS study is to enroll about 1,000 women with certain gynecologic conditions to share their medical history and provide a saliva sample, which contains genetic material. We want to better understand what medical, lifestyle, background, and genetic factors may be related to these conditions.
  • Isothiocyanates as Specific Antagonists of Suman SXR
    Public Health Sciences
  • Janes Lab
    Vaccine and Infectious Disease
  • Jerome Lab
    Vaccine and Infectious Disease
  • Jerome Lab
    Vaccine and Infectious Disease
    Chronic and latent phases of virus infections, virus immune evasion mechanisms, and potential curative therapeutic approaches to these infections.
  • Kemp Lab
    Human Biology
    The Kemp Lab studies tumor formation in mice to better understand how environmental and genetic factors interact to cause cancer. They also work to develop simple blood tests for early cancer detection by discovering biomarkers, the proteins that signal the earliest traces of disease.
  • Kiem Lab
    Clinical Research
    The Kiem Lab studies stem cell biology and stem cell gene transfer with the goal of developing new treatment strategies for patients with genetic and infectious diseases and cancers.
  • Kooperberg Website
    Public Health Sciences
  • Laboratory for the Study of Metastatic Microenvironments
    Understanding how microenvironments within distant tissues regulate dormancy and growth of disseminated breast tumor cells.
  • Lampe, P Lab
    Public Health Sciences
    The Paul Lampe Lab attempts to discover early detection cancer biomarkers and investigates the control of cell growth at the cell biology level. Of particular interest is the role that gap junctions play in the regulation of cell growth and the cell cycle, and the disruption of this relationship during cancer development.
  • Lee Lab
    Clinical Research
  • Li Lab
    Public Health Sciences
    Dr. Li uses a multidisciplinary approach to understand factors related to the causes and patient outcomes of breast cancer. Current projects include identifying new biomarkers that could be used for early detection, evaluating risk factors for different types of breast cancer, determining predictors of poor outcomes among breast cancer survivors, and assessing disparities in cancer stage, treatment and survival by race/ethnicity.
  • Long-Term Follow-Up
    Clinical Research
  • Long-term Follow-up of the Family And Cancer Therapy Selection (FACTS) Study Participants
    Public Health Sciences
  • Lund Lab
    Vaccine and Infectious Disease
  • Lymphoma Program
    Clinical Research
  • MacPherson Lab
    Human Biology
    The MacPherson Lab is focused on understanding the mechanisms through which cancer-mutated genes drive tumorigenesis. The lab studies two tumor types, small cell lung carcinoma (SCLC) and retinoblastoma. Genomic analyses of human tumors allow us to identify gene mutations that may contribute to tumor initiation, progression and metastasis.
  • Madeleine Lab
    Public Health Sciences
    Dr. Madeleine's research focuses primarily on the molecular epidemiology of disease-causing agents, or pathogens, and the immune response to them that may be associated with cancer development and prognosis. Another interest is the role of chronic, undiagnosed immune system dysfunctions (such as those occurring with age, obesity, physical inactivity, hormone use, and UV exposure) in cancer development.
  • Malik Lab
    Basic Sciences
    The Malik Lab hunts for rapidly evolving proteins in order to understand how conflicts between genes affect human evolution. Such genetic conflicts can arise between virus and host genes as each fights for survival, but they can affect the function of essential genes, including those implicated in cancer.
  • Markers of B-Cell Stimulation as Potential Predictors of Non-Hodgkin Lymphoma
    Public Health Sciences
    We are conducting a nested case-control study of biologic markers of a B-cell stimulatory host environment as predictors of B-cell NHL among 500 cases and 500 pair-matched controls from the WHI Observational Study (OS), among whom biologic samples were collected an average of 10 years before NHL diagnosis.
  • Matsen Group
    Public Health Sciences
  • McElrath Lab
    Vaccine and Infectious Disease
    The McElrath Lab is dedicated to understanding the human immune response mechanisms in HIV infection and resistance in a way that can be translated into the development of an effective HIV vaccine.
  • McGregor Lab
    Public Health Sciences
    The McGregor Lab leads the Stress Management and Relaxation Training, or SMART, studies, which focus on understanding the effects of stress management on behavioral and biological factors that are relevant to cancer development, such as diet, exercise, immune function, DNA repair and cellular aging processes.
  • McIntosh Lab
    Public Health Sciences
    The McIntosh Lab develops primarily computational approaches for studying proteins and genomes in cancer. Their primary goal is to discover and evaluate diagnostic and early-detection biomarkers in serum, with research projects in ovarian, breast and pancreatic cancer and neurodegenerative diseases.
  • Menopausal Symptoms Initiative: Finding Lasting Answers for Sweats and Hot Flashes (MSI-FLASH)
    Public Health Sciences
  • Migraine, Migraine Medication Use, and Breast Cancer Risk
    Public Health Sciences
  • Modeling Folate, One-Carbon Metabolism & DNA Methylation
    Public Health Sciences
  • Modeling Ovarian Cancer Screening for CEA
    Public Health Sciences
  • Moens Lab
    Basic Sciences
    The Moens Lab uses zebrafish as a model system to study how genes control the early development of the brain in vertebrates. Their work adds to our understanding of the causes of cancer because many of the genes that control embryonic development are the same ones that are wrongly regulated in cancer cells.
  • Molecular Change and Thyroid Cancer Risk After Chernobyl
    Public Health Sciences
    This study will investigate the occurrence and molecular characteristics of thyroid cancer in residents of the Bryansk Oblast of the Russian Federation who were up to 50 years of age at the time of exposure to radiation from the Chernobyl Power Station accident on April 26, 1986.
  • Molecular Epidemiology Lab
    Public Health Sciences
    The Molecular Epidemiology Lab provides investigators working on population-based studies with laboratory-based research expertise through a collaborative scientific relationship. The lab is headed by Dr. Karen W. Makar in the Cancer Prevention Program and supports epidemiological and clinical investigators at FHCRC and their collaborators at other institutions.
  • Molecular Epidemiology of Endometrial Cancer
    Public Health Sciences
    This study tests the hypotheses that the risk of developing endometrial cancer is related to variation in genes that encode for enzymes: 1) involved in the biosynthesis or catabolism of estrogens, or in the response to steroid hormones, and 2) that repair DNA damage generated during estrogen exposure.
  • Molecular Epidemiology of Lung Cancer
    Public Health Sciences
    A study determining whether polymorphisms of enzymes involved in the repair of smoking-induced DNA damage, namely those from the base excision (BER) and nucleotide excision repair (NER) pathways, are associated with risk of lung cancer.
  • Move and Moderate in Balance (MOVE'M): A TREC Worksite Health Study
    Public Health Sciences
    A study related to a diet and exercise regimen that individuals can follow to achieve balance in their energy intake and expenditure
  • Mueller Lab
    Public Health Sciences
    Dr. Mueller's research focuses on the roles of maternal, gestational, early life factors, and early environmental exposures in the occurrence of childhood cancer and autoimmune diseases. She also studies reproductive history in relation to cancer and cancer survival in women, and reproductive outcomes among male and female childhood cancer survivors.
  • Neiman Lab
    Basic Sciences
  • Nelson Lab
    Clinical Research
    The J. Lee Nelson Lab studies microchimerism, a natural state in which cells are exchanged between mother and fetus during pregnancy and can remain in the other individual decades later. They study the role of this phenomenon in autoimmune diseases, pregnancy complications and cancer, as well as its impact on the success of blood stem-cell and organ transplants.
  • Night Shift Workers and Hormone Levels in Men
    Public Health Sciences
    This study will be the first effort to assess the effects of night shift work on melatonin and the hormones of most interest in the etiology of prostate cancer.
  • Night Shift Workers and Hormone Levels in Women
    Public Health Sciences
  • NSAIDs and Other Medications in Prostate Cancer Etiology
    Public Health Sciences
    The objective of this study is to determine whether use of NSAIDs and other frequently used medications are associated with risk of prostate cancer.
  • Nutrition and Physical Activity Assessment
    Public Health Sciences
  • Nutrition and Physical Activity Assessment
    Public Health Sciences
    This project focuses on the use of biomarkers to evaluate and compare measurement properties of prominent nutritional and physical activity assessment methods, and on the use of biomarker-calibrated nutrient consumption and activity-related energy expenditure estimates in disease association studies in the Women’s Health Initiative (WHI) cohorts of postmenopausal women.
  • Nutrition Assessment Shared Resource (NASR)
    Public Health Sciences
    A resource that aids investigators in incorporating state-of-the-art dietary data collection methods into their studies
  • Nutrition, Thymic T-Cell Production and control of HIV
    Public Health Sciences
    A study to determine if poor nutrition contributes to the high risk of viral cancer in HIV-infected adults in Uganda
  • Obesity, Body Fat Distribution and Cancer Risk in the Multiethnic Cohort
    Public Health Sciences
  • Oehler Lab
    Clinical Research
  • Olsen Lab
    Basic Sciences
    The Olsen Lab uses a combination of lipid biochemistry and genetics to study membrane maintenance in the nematode, C. elegans. Cellular membranes are affected in many diseases and in natural aging, and our main goal is to define genes that are important for preserving proper membrane composition and function.
  • Olson Lab
    Clinical Research
    The Olson Lab studies pediatric brain tumors, brain development and neurodegenerative disorders. The lab has a strong focus on emergent technologies such as "tumor paint," which causes cancer cells to glow with light so that surgeons can see them during an operation.
  • Oral Cancer: Molecular Profiles & Clinical Outcomes
    Public Health Sciences
    Our goals in this study are to determine whether: 1) The prognosis of OSCC patients is associated with tumor gene expression profiles; 2) OSCC tumor characteristics known to be related to patient outcome - such as stage and nodal status - are associated with tumor gene expression profiles; and 3) Tumor gene expression differs among invasive OSCC, pre-neoplastic oral squamous cell lesions, and normal oral tissue.
  • Overbaugh Lab
    Human Biology
    The Overbaugh lab has a long-standing interest in understanding the mechanisms of HIV-1 transmission and pathogenesis. The lab is part of a larger team, comprising researchers in both Seattle and Kenya (The Nairobi HIV/STD Project). Trainees in the lab have opportunities to engage in studies of viral evolution, virus-host cell interactions, and viral immunology all within the context of international collaboration.
  • PACE [Promoting Activity and Changes in Eating] Project
    Public Health Sciences
    A project to develop simple strategies for moderating dietary intake and increasing energy expenditure for individuals at the worksite level
  • Pacific Northwest Prostate Cancer SPORE
    Public Health Sciences
  • Pacific Ovarian Cancer Research Consortium (SPORE in Ovarian Cancer)
    Public Health Sciences
  • Paddison Lab
    Human Biology
    The Paddison Lab uses functional genetics to probe the underlying biology of mammalian stem/progenitor cells. We identify and characterize gene products affecting stem cell self-renewal, differentiation, proliferation, or survival through the use of RNAi knockdown technologies.
  • Pagel Lab
    Clinical Research
    The Pagel lab focuses on the development and improvement of antibody therapies for leukemia and lymphoma, with the goal of decreasing toxic side effects while increasing the treatment's effectiveness. Our projects focus on advancing radioimmunotherapy through a pre-targeted method of delivering radiation to tumor sites.
  • Parkhurst Lab
    Basic Sciences
    The Parkhurst Lab studies how genes get turned on and off as fruit-fly embryos develop and how errors in this process can lead to cancer and other diseases. They also investigate wound healing and complex signals involving proteins that can affect a cell's "skeletal" structure.
  • Partnership for a Hispanic Diabetes Prevention Program
    Public Health Sciences
  • Partnership for the Advancement of Cancer Research Project
    Public Health Sciences
    The National Cancer Institute (NCI) has awarded funds to enhance and expand an existing collaboration between New Mexico State University (NMSU) and the Fred Hutchinson Cancer Research Center (FHCRC). This collaboration is designed to enhance the opportunities of minorities and underrepresented individuals, including Hispanics and Native Americans, to become trained and experienced in cancer research.
  • Paulovich Lab
    Clinical Research
    The Paulovich Lab works to characterize human variation and to relate this variation to clinically relevant endpoints, such as predicting a patient's risk of cancer and tolerance for treatments. Projects range from studying cellular DNA damage response in yeast and mammalian cells, to developing novel mass spectrometry-based technologies for finding and validating new protein biomarkers to serve as diagnostic tests.
  • Peichel Lab
    Human Biology
    The Peichel Lab uses a small fish called the threespine stickleback as a model organism to conduct research aimed at identifying the genetic and molecular mechanisms that underlie evolutionary processes. Research topics include understanding evolution of the fish's behavior and sex chromosomes.
  • Pepe Lab
    Public Health Sciences
    The Pepe Lab develops guidelines and software to promote the use of sound statistical methods by scientists who are working to evaluate diagnostic or prognostic medical devices and biomarkers.
  • Peter Gilbert Group
    Vaccine and Infectious Disease
  • Peter Nelson Lab
    Human Biology
    Dr. Peter Nelson's lab focuses on understanding the molecular, cellular and physiological events that lead to cancer initiation and progression. A particular emphasis involves hormonal carcinogenesis and prostate cancer with the goal of developing new strategies for diagnosis, prognosis and therapy.
  • Peters Studies
    Public Health Sciences
    Peter's Lab research is focused on the genetic and molecular epidemiology of common complex diseases, including cancer, obesity, type 2 diabetes, and cardiovascular diseases, as well as intermediate traits, including inflammation and metabolic measurements. Within well characterized and diverse study populations, we are studying the impact of common and rare genetic variants across the entire genome, as well as interactions between genetic variants and environmental factors (such as diet, exercise, smoking and aspirin use).
  • Pharmacogenetics of the Folate Pathway
    Public Health Sciences
    A study to investigate polymorphisms in proteins important for folate metabolism and their effect on the toxicity and effectiveness of methotrexate, a drug widely used in cancer chemotherapy
  • Physical Activity for Total Health (PATH)
    Public Health Sciences
    The goal of the study is to examine how moderate exercise may lower breast cancer risk
  • Physical Activity in the Cambodian Community
    Public Health Sciences
  • Polymorphisms in PG/COX Pathway and Colorectal Polyps
    Public Health Sciences
    The goal of this study is to evaluate the association between common genetic changes in enzymes, growth factors, and receptors linked to prostaglandin synthesis or COX activity and the risk of precancerous colon polyps
  • Population Architecture using Genomics and Epidemiology (PAGE)
    Public Health Sciences
  • Population-based Research Optimizing Screening through Personalized Regimens (PROSPR)
  • Porter Lab
    Human Biology
    The Porter Lab focuses on identifying and understanding the molecular events in normal and cancer cells that are associated with the initiation and progression of human cancer, with a focus on breast and ano-genital cancers. They also investigate the molecular profiles that distinguish different types of cancer or determine an individual's cancer risk.
  • POWDER Study
    Fred Hutch researchers are working to understand the challenges women with disabilities face when pregnant and birth outcomes among women with chronic conditions that may restrict mobility or care access.
  • Press Lab
    Clinical Research
    Dr. Press is a pioneer in immunotherapy, a treatment strategy that harnesses the power of the immune system. His lab engineers antibodies that help to destroy cells involved in blood cancers and carry radiation directly to cancer cells. They also genetically modify disease-fighting T-cells to boost their ability to recognize and kill lymphoma cells.
  • Priess Lab
    Basic Sciences
    The Priess lab studies how cells coordinate their shape and fate during the development of complex tissues and organs. Most of these studies use the nematode C. elegans as a model organism.
  • Prlic Lab
    Vaccine and Infectious Disease
    The Prlic Lab primarily focuses on two populations of the adaptive immune system: CD8 T cells and NK cells. The lab studies these cells in a variety of different in vivo (mouse) and in vitro model systems to gain mechanistic insight and learn how to manipulate these cells for therapeutic purposes.
  • Program in Global Oncology/Hutch in Uganda
    Vaccine and Infectious Disease
  • Program in Prostate Cancer Research
    Public Health Sciences
    The Program in Prostate Cancer Research at Fred Hutchinson Cancer Research Center is a multidisciplinary program. The aim is to foster interactive communication and the development of new or expanded research projects between investigators with diverse expertise and interest in prostate cancer.
  • PROGRESS Study
    Public Health Sciences
  • Prospective Study of Selenium, Genetics of Selenoenzymes and Colorectal Cancer
    Public Health Sciences
  • Prostaglandin Synthesis, Genetics, and Colorectal Cancer (ColoCox)
    Public Health Sciences
  • Protein Biomarkers of Cancer Risk in Older Persons
    Public Health Sciences
    Using a case-cohort study design, this study evaluates if baseline plasma proteomic patterns can be used to distinguish between subjects who will and will not develop breast, colorectal, lung, and prostate cancers.
  • Protein Biomarkers of Cancer Risk in Older Persons
    Public Health Sciences
    Study evaluates if baseline plasma proteomic patterns can be used to distinguish between subjects who will and will not develop breast, colorectal, lung, and prostate cancers. In addition, it evaluates if the addition of known risk factors for these cancers.
  • Proteomics and the Health Effects in Postmenopausal Hormone Therapy
    Public Health Sciences
  • Puget Sound Oncology Consortium
    Clinical Research
    Secure member site for the Puget Sound Oncology Consortium (PSOC) - a non-profit corporation located at the Fred Hutchinson Cancer Research Center. Physicians in the Puget Sound area established PSOC in 1983 to conduct and promote clinical trials.
  • Quilt Study
    Public Health Sciences
    The Quilt Study is a study of predictors of disease progression and recurrence in women diagnosed with breast cancer at ages 45-79 to identify pre- and post-diagnosis exposures and events that may increase the risk of recurrence; assess pre-diagnosis exposures for their association with tumor characteristics and risk of recurrence; and evaluate how tumor markers, both ones currently used in clinical care and novel ones not currently in use, relate to breast cancer progression or recurrence across age groups.
  • Radiation and Environmental Exposure Studies
    Public Health Sciences
    The REES group focuses on identifying risk factors and causes of cancer and other diseases associated with many types of environmental exposures, including radiation, persistent organic pollutants, electromagnetic fields, and factors that disrupt normal circadian rhythm. Projects have focused on breast cancer, thyroid cancer and other thyroid diseases, lymphomas, and myelodysplastic syndrome.
  • Radich Lab
    Clinical Research
    The Radich Lab studies the molecular genetics of response, progression and relapse in human leukemia. Research topics include the detection of minimal residual disease, the role of signal transduction abnormalities in leukemia, and the construction of gene-expression profiles of response and progression.
  • Randolph Lab
    Public Health Sciences
    The Randolph Program's research focuses on mathematical and statistical methods for high-dimensional, functional and otherwise "non-standard" data including: image-based data, mass spectrometry, various spectroscopies, microbiome and genetic arrays as well as longitudinal data. Projects and collaborations involve studies for discovery and validation of molecular properties and markers of disease.
  • Random Digit Dialing Methodology for the 21st Century
    Public Health Sciences
  • REACH Group
    Public Health Sciences
    Dr. Ramsey directs the Research and Economic Assessment in Cancer and Healthcare (REACH) group, which focuses on cutting-edge cost-effectiveness and outcomes research in cancer prevention and treatment. REACH also has experience in designing and performing cost-effectiveness analyses of drugs, devices and interventions, with an eye towards supporting public and private decision making to maximize health value under resource constraints.
  • REACH Study
    Public Health Sciences
    The purpose of the REACH Study is to further our understanding of why some young women develop breast cancer and others do not. Studies like the REACH Study compare information from people who have a particular disease to those who do not.
  • REDA Study - The Reproducibility of EDA
    Public Health Sciences
    Research suggests that estrogen (EDA) levels may be useful to assess a woman's risk of breast cancer, although it is yet unclear which forms of estrogens provide the most information. The goal of this study is to find out if they vary over time or stay at constant levels in healthy women.
  • Reducing Pesticide Exposure in Children of Farm Workers
    Public Health Sciences
    The overall goal of this study is to reduce pesticide exposure in children of farm workers in the Yakima Valley of Washington state, by breaking the pesticide "take-home" pathway
  • Regulation of Intercellular Communication
    Public Health Sciences
  • Reid Lab
    Human Biology
    The Reid Lab is focused on understanding the mechanisms by which environmental exposures (i.e. aspirin or other nonsteroidal antiinflammatory agents) affect the evolution of clones that lead to the development of esophageal adenocarcinoma in patients with Barrett's esophagus.
  • Research Cell Bank
    Clinical Research
    The Research Cell Bank (RCB) is a qualified, experienced research facility that has been actively engaged in clinical research through B-lymphoblastoid cell (B-LCL) transformation and maintenance, DNA extraction, and inventory control for more than 30 years. The RCB is currently expanding its role as a core repository of reagents and services to better serve the needs of investigators worldwide.
  • Residential Proximity to Industrial Facilities and Risk of Non-Hodgkin Lymphoma
    Public Health Sciences
    We are investigating long-term environmental exposure to industrial pollutants as a risk factor for NHL.
  • Risk Factors for Second Primary Breast Cancer Among DCIS Survivors
    Public Health Sciences
    The study of epidemiological factors, clinical and pathological characteristics, and tumor marker expression influence the risk of second primary invasive contralateral breast cancer among survivors of a first primary invasive breast cancer.
  • Risk Prediction Symposium 2014
  • Roberts Lab
    Basic Sciences
    The Roberts Lab has discovered key proteins that regulate cell division and explored how changes in cell-cycle proteins may inform the treatment of specific cancers. Current research focuses on the development of mouse models of human cancers.
  • Role of Air Pollution in Rheumatoid Arthritis Incidence and Exacerbation
    Public Health Sciences
    This study is investigating ambient air pollution as a contributor to rheumatoid arthritis (RA) incidence and exacerbation, with a focus on exposure to particulate matter.
  • Role of Missense Changes in the BRCA1 and BRCA2 Breast Cancer Susceptibility Genes in Breast Cancer Among African-American Women: A Population-Based Approach
    Public Health Sciences
    The aims of this project are to conduct a series of statistical and laboratory analyses, using data and samples from a recently completed population-based study of breast cancer, to investigate the clinical significance of missense changes in BRCA1 and BRCA2 in African-American women.
  • Roth Lab
    Basic Sciences
    The Roth Lab studies suspended animation and metabolic hibernation as a means to temporarily halt, or "dial down," metabolism. One day such techniques may help to buy time for critically ill patients on organ-transplant lists and in trauma situations.
  • Salama Lab
    Human Biology
    The Salama lab studies the gastric bacterial pathogen Helicobacter pylori, which infects half the world's population and can cause ulcers and gastric cancer.
  • Schiffer Group
    Vaccine and Infectious Disease
    The Schiffer Group aims to gain a better understanding of the quantitative features of human pathogens and immune responses. In close collaboration with colleagues at the Fred Hutchinson Cancer Research Center and the University of Washington, the Group designs mathematical models that capture growth and decay kinetics of infectious organisms. These models attempt to replicate detailed empirical datasets, and in turn are used to inform subsequent human studies and laboratory experiments.
  • SCOT Study
    Public Health Sciences
    The SCOT Study was funded by the National Institutes of Health and directed by Dr. Madeleine at the Fred Hutchinson Cancer Research Center and co-investigators at local transplant institutions, including the University of Washington, Virginia Mason and Swedish Medical Centers. We are analyzing the study data to learn more about factors like genetics or viruses that may be involved in why many transplant patients develop skin cancer after transplant.
  • Seattle 5 a Day Worksite Program: Eat 5 for Life
    Public Health Sciences
    A randomized trial to evaluate the effectiveness of an intervention to maintain change in companies that have already received an intervention to increase fruit and vegetable consumption
  • Seattle Barrett's Esophagus Research Program
    The Seattle Barrett's Esophagus Research Program is committed to understanding the genetic mechanisms and environmental risk factors that ultimately result in cancer of the esophagus, and identifying intermediate genetic markers that will allow for the early identification of patients at an increased risk of developing esophageal cancer so that the cancer can be prevented or detected when it is early and the patient can be cured.
  • Selenium, Genetic Variation in Selenoenzymes and Prostate Cancer
    Public Health Sciences
  • SHARE Study
    Public Health Sciences
    The focus of the SHARE Study is to determine risk factors specific to three different types of breast cancer. Studies like this one compare information from people who have a particular disease to those who do not. This type of research allows us to identify what specific characteristics of exposures may cause different types of breast cancer.
  • Shared Host Genetics and Bacterial Adaptation in the Transmission of H. pylori
    Public Health Sciences
  • Shimamura Lab
    Clinical Research
    The Shimamura Lab works to understand the molecular mechanisms contributing to development of blood cells (hematopoiesis) and cancer (tumorigenesis), with the ultimate goal of informing rationally designed therapeutic strategies. Their research focuses particularly on genetic marrow failure syndromes.
  • Shou Lab
    Basic Sciences
    The Shou Lab uses experimental biology, mathematics and engineering to study a variety of biological problems. Research interests include how cooperative systems evolve despite threats from "cheaters" that consume benefits without paying a fair cost, and how cells cope with nutrient limitations.
  • Simon Lab
    Clinical Research
    The Simon Lab works toward identifying new anticancer drugs through a wide range of experimental techniques and systems, ranging from organic synthesis to genetic screens.
  • Smith Lab
    Basic Sciences
    The Smith Lab works to understand how genetic recombination and DNA repair are accomplished, and how they are regulated to occur at the proper place and time. As deviations in this process can result in birth defects and cancers, this work may lend insight into the causes of these diseases and ways of predicting or preventing them.
  • Spies Lab
    Clinical Research
    The Spies Lab focuses on experimental studies of the human NKG2D lymphocyte receptor and its ligands, and the mechanisms whereby these proteins stimulate or suppress immune responses against cancer and in autoimmune disease.
  • SPORE Supplement: Phase III Validation of a Consensus Panel of Ovarian Cancer Biomarkers Developed by SPORE/EDRN investigators
    Public Health Sciences
  • Statistical Methods for Medical Studies
    Public Health Sciences
  • Stephan Lab
  • Stoddard Lab
    Basic Sciences
    The Stoddard Lab studies the structure and mechanism of enzymes, the body's catalysts of biological reactions, in order to harness them for use in biotechnology and medicine. The engineering and redesign of certain enzymes could be used in targeted therapies for genetic diseases such as hemophilia and cystic fibrosis.
  • Storb Lab
    Clinical Research
    Transplantation Biology combines basic and translational research directed at understanding and eliminating major barriers to successful allogeneic hematopoietic stem cell transplantation; these include host-versus-graft reactions, graft failure, acute and chronic graft-versus-host disease (GVHD), regimen-related toxicities, and induction of graft-versus-tumor reactions. The program’s goal has been to use stem cell transplantation to treat patients with malignant and nonmalignant hematologic diseases.
  • Strong Lab
    Basic Sciences
    The Strong Lab analyzes the structure of proteins and protein-receptor complexes that control the immune system's response to disease. Building on the principles learned from these studies, they also participate in a collaborative project to design proteins for a vaccine to prevent AIDS.
  • Survivorship Program
    Clinical Research
    Fred Hutchinson Cancer Research Center's Survivorship Program offers support, treatment and education to cancer survivors. A member of the LIVESTRONG Survivorship Center of Excellence Network, the Survivorship Program is helping to lead a nationwide effort to help survivors and their healthcare providers understand, prevent and manage the medical and psychosocial effects of having cancer and receiving treatment.
  • Tamoxifen & Second Breast Cancer: Epidemiology and Pathology
    Public Health Sciences
    The purpose of this population-based nested case-control study is to evaluate how treatment with tamoxifen influences a breast cancer survivor's risk of developing a second, or contralateral, breast cancer.
  • Taniguchi Lab
    Human Biology
    The Taniguchi Lab's long-term research objective is to elucidate molecular mechanism of DNA damage response pathways, such as the Fanconi Anemia-BRCA (FA-BRCA) pathway, and their involvement in carcinogenesis.
  • Tapscott Lab
    Human Biology
    The Tapscott Lab studies gene transcription and expression in normal development and disease, with an additional emphasis on rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other research areas include gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.
  • Tewari Lab
    Human Biology
    The Tewari Lab draws on perspectives from systems biology and complexity science to address important problems in basic and applied cancer research. More specifically, the lab is investigating microRNAs, which are 22 nt non-protein-encoding RNA molecules that function to repress messenger RNA targets to modulate gene expression networks.
  • Thompson Studies
    Public Health Sciences
    Led by Dr. Beti Thompson, this research group works to understand why disparities in cancer incidence and survival rates exist among different populations, especially Latinos. The group also supports efforts to reduce other health disparities, including diabetes and pesticide exposure, in minority communities in the United States and abroad.
  • Tobacco & Health Behavior Science Research Group
    Public Health Sciences
    This group, led by Dr. Jonathan Bricker, focuses on two key questions: (1) Can innovative theory-based behavioral interventions succeed in changing unhealthy behaviors (e.g., smoking)?; (2) Why do people engage in unhealthy behaviors (e.g., smoking)?
  • Transdisciplinary Research on Energetics and Cancer (TREC)
    Public Health Sciences
  • Translational Research Program
    Public Health Sciences
  • Transmission of Stomach Bacteria Study
    Human Biology
    Fred Hutchinson Cancer Research Center is recruiting families to participate in a study about the transmission of Helicobacter pylori, a stomach bacteria infecting half of the world's population. The bacteria can cause ulcers and stomach cancer.
  • Tsukiyama Lab
    Basic Sciences
    The Tsukiyama Lab studies chromatin, the complex of DNA and proteins that make up our chromosomes, and how chromatin structure controls essential processes that take place on DNA.
  • Tumor Vaccine Group
    Clinical Research
  • Ulrich Lab
    Public Health Sciences
    The Ulrich Group conducts research related to cancer prevention, prognosis and survivorship, with an emphasis on colorectal cancer. Topics of study include the effects of folate, vitamin D, exercise, diet and genetics on cancer risk, prognosis and treatment outcomes, and biological markers of cancer risk.
  • Understanding and Preventing Breast Cancer Disparities in Latinas
    Public Health Sciences
    This program is designed to better understand and address inequities associated with the two leading causes of death in the United States; cancer and cardiovascular disease.
  • Use of Exogenous Progestins and Risk of in situ and Invasive Breast Cancer
    Public Health Sciences
    The first project investigates the relationship between use of depo-medroxyprogesterone acetate on risk of in situ breast cancer among premenopausal women 20-44 years of age. The second study is a population-based case-control study evaluating the relationship between use of progestin containing hormone therapy regimens and risk of invasive pure lobular, ductal/lobular, and ductal carcinomas among postmenopausal women 55-74 years of age.
  • Vasioukhin Lab
    Human Biology
    The Vasioukhin lab studies the mechanisms and significance of cell polarity and cell adhesion in normal mammalian development and cancer. In addition, we have a significant interest in the mechanisms responsible for initiation and progression of human prostate cancer. We believe that it is important to study cells in their normal microenvironment.
  • Vaughan Group
    Public Health Sciences
  • Vitamin D and Adipose Tissue inflammation
    Public Health Sciences
  • Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation
    Public Health Sciences
  • Vitamin D, Diet and Activity Study
    Public Health Sciences
    The Vitamin D, Diet and Activity (ViDA) Study is being conducted to determine whether Vitamin D can help decrease breast cancer risk by reducing body fat or decreasing weight gain.
  • VITamins And Lifestyle (VITAL) Study: A Cohort Study of Dietary Supplements and Cancer Risk
    Public Health Sciences
  • Walter Lab
    Clinical Research
    Research is focused on clinical trials testing new drugs and drug combinations to treat acute myeloid leukemia.
  • Wang Program
    Public Health Sciences
    The Wang Lab focuses on developing statistical and computational methods to address scientific questions based on data from high throughput biology/genetics experiments. The ultimate goal is to enhance our understanding of cell activities and disease initiation/progression to a system level by integrating information from diverse biological sources (genetics/genomics, proteomics, and phenotypes).
  • Warren Lab
    Clinical Research
    The Warren Lab studies human antitumor immune responses at the cellular and molecular level in order to learn how these immune responses can be exploited to treat human cancer.
  • WECARE Study: Interaction of Radiation, BRCA 1/2 and Breast Cancer
    Public Health Sciences
    A study to investigate gene-environment interactions influencing susceptibility in the etiology of breast cancer.
  • Women's Health Initiative
    Public Health Sciences
    The Women’s Health Initiative (WHI) is a major, long-term research program designed to address cardiovascular disease, cancer and osteoporosis – the most frequent causes of death, disability and poor quality of life in postmenopausal women. Fred Hutch is home to the study's coordinating hub, led by Dr. Garnet Anderson and colleagues Drs. Ross Prentice, Andrea LaCroix, and Charles Kooperberg
  • Women’s Health Initiative Clinical Coordinating Center Extension, 2011-2015
    Public Health Sciences
    A clinical trial testing the risks and benefits of different treatments in relation to the overall health of post-menopausal women
  • Women’s Health Initiative Sequencing Project (WHISP)
    Public Health Sciences
  • Wu Group
    Public Health Sciences
  • Youth & Adult Smoking Research
    Public Health Sciences
    Youth and Adult Smoking Research works to learn more about attitudes and practices about smoking and non-smoking in teens. To learn how they change from their teen years to their young adult years. And to develop and test interventions for smoking prevention and smoking cessation, to see if they can help teens avoid and/or quit smoking.

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