Asia Cohort Consortium Public Health Sciences The Asia Cohort Consortium (ACC) is a collaborative effort seeking to understand the relationship between genetics, environmental exposures, and the etiology of disease through the establishment of a cohort of at least one million healthy people around the world.
Bedalov Lab Clinical Research The Bedalov Lab conducts research to identify drugs that disrupt gene silencing, a process that has been implicated in cancer and other diseases in which genes are inappropriately shut off.
Bernstein Lab Clinical Research Dr. Irwin D. Bernstein's research interests include normal and leukemic hematopoietic stem cells, antibody targeted therapies for lymphoma and leukemia, and the biology of acute myeloid leukemia.
Beronja Lab Human Biology Regulation of epithelial growth in development and cancer. Tissue growth is a fundamental biological process that generates functional organs in development, and maintains them in the adulthood through continuous cycles of renewal and repair.
Bielas Lab Public Health Sciences The Bielas Lab studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the development of cancer and age-related disease. Translational research projects explore the potential utility of these mutations as novel DNA biomarkers for improved disease detection, treatment outcome, survival and quality of life.
Biggins Lab Basic Sciences The Biggins Lab uses budding yeast to study chromosome segregation, the process by which chromosomes are distributed to new cells during cell division. Cells with an abnormal number of chromosomes are a hallmark of cancer and many birth defects.
Biobehavioral Sciences Clinical Research The Biobehavioral Sciences program investigates mechanisms and methods for integrating behavioral and biological components of care for cancer survivors during and following active treatment.
Bloom Lab Basic Sciences The Bloom lab uses a combination of experimental and computational approaches to study the molecular evolution of proteins and viruses. A major goal is to understand the underlying biophysical and immunological constraints that shape influenza evolution.
Boeckh Lab Vaccine and Infectious Disease The long-term goal of the Boeckh Research Program is to prevent infectious disease in immunocompromised hosts and reduce the severity of infections that do occur. We focus on herpes viruses (primarily cytomegalovirus), respiratory viruses, and the genetics of susceptibility to infection.
Bolouri Lab Human Biology The Bolouri Lab is interested in understanding how gene regulatory interactions control cellular state and identity, particularly during development (e.g. in stem cells). The lab specializes in the development and use of computational systems biology methods to map gene regulatory networks.
Bradley Lab Basic Sciences The Bradley Lab uses genomics and molecular genetics to study alternative splicing, the process by which a single gene can give rise to multiple, distinct protein isoforms. Alternative splicing enormously increases the complexity of eukaryotic genomes, and plays important roles in many human diseases.
BRAVO Study Public Health Sciences The purpose of the BRAVO Study is to understand what causes different types of breast cancer. It will include women who have experienced breast cancer, from age 20 to age 69, living in Washington state and New Mexico.
Breast Cancer Risk and Molecular Change After Chernobyl Public Health Sciences This study has two primary aims: 1) to investigate whether the risk of premenopausal breast cancer is associated with individual radiation dose to the breast from the Chernobyl accident, to estimate the risk per unit dose, to investigate the shape of the dose- response, and potential dose effect modifying factors, including molecular characteristics and established breast cancer risk factors; and 2) to investigate whether the association of breast cancer risk with radiation exposure differs according to characteristics of breast cancer, including hormone receptor status, genomic loss and gain, and specific alterations in 14 selected DMA repair genes.
Breast Health Global Initiative Public Health Sciences The Breast Health Global Initiative (BHGI), co-sponsored by Fred Hutchinson Cancer Research Center and Susan G. Komen for the Cure®, pioneered development of comprehensive resource-sensitive, evidence based clinical Guidelines for International Breast Health and Cancer Control to improve breast cancer outcomes in low- and middle-resource countries (LMCs) through the collaboration of an alliance of dedicated organizations and individuals.
Breeden Lab Basic Sciences The Breeden Lab investigates control of cell division in budding yeast, with a long-term goal of understanding how the commitment to the mitotic cell cycle is regulated in response to environmental and internal cues.
Brent Lab Basic Sciences The Brent Lab studies how living cells sense, represent, transmit and act upon information to make decisions about their future states. The lab includes, experimentally, a social science component, in which lab members are encouraged to identify and analyze how their research outcomes and ongoing increases in biological knowledge might impact human affairs.
Buck Lab Basic Sciences The Buck lab studies the mechanisms and neural circuits that underlie the sense of smell and pheromone sensing in mammals. They are also interested in aging.
Cancer Biology Program Public Health Sciences The Cancer Biology Program, which was formed in 1991, is comprised of seven laboratories that provide opportunities for new research directions that complement and benefit from the epidemiology and cancer prevention components of the Public Health Sciences Division.
Cancer Surveillance System Public Health Sciences The Cancer Surveillance System (CSS) collects population-based data on cancer incidence and survival in 13 counties in western Washington State. These cancer data are collected to provide public health scientists and practitioners with the ability to track trends in the incidence of all forms of cancer (surveillance); identify and investigate patterns of cancer occurrence (epidemiology); and monitor of trends in mortality and survival for specific cancers (end results).
CAREGEN: Genetic susceptibility and the risk of breast cancer Public Health Sciences This is an ancillary study of the NICHD Women’s CARE Study, a large population-based multi-center case-control study among Caucasian and African-American women that is designed primarily to evaluate the risk of breast cancer in women ages 35-64 in relation to oral contraceptive (OC) use and hormone replacement therapy (HRT).
Carlson Group Public Health Sciences The Carlson Group uses genetic epidemiology to investigate the genetic risk factors of diseases such as cancer, cardiovascular and neurological disease. The group identifies statistical correlations between variations and disease. The group's molecular biology laboratory is then equipped to assess the molecular mechanisms behind these correlations. Recently, the lab has played a significant role in development of technologies for adaptive immune system profiling, in collaboration with Harlan Robins and Hootie Warren. These tools are being applied to a variety of arenas.
Chen Lab Public Health Sciences The Chu Chen Lab is conducting a hospital-based study to discover biomarkers that may improve diagnosis and prognosis of oral cancer. Several other studies focus on the links between genetic and environmental factors and development of, and/or survival from, tobacco-related and hormone-related cancers.
Clurman Lab Clinical Research The Clurman Lab studies how cell division is regulated in normal cells, and how abnormal control of cell division leads to cancer. They hope to use these mechanistic insights into tumor formation to develop new cancer treatment strategies.
Cocoa Flavanols and Multivitamin Supplements Public Health Sciences The Women’s Health Initiative will be conducting a five-year, large-scale randomized controlled trial to test the effect of a concentrated cocoa extract and multivitamin supplements in reducing risks of CVD and cancer.
Computational Biology Public Health Sciences Members of the Computational Biology Program use and develop novel computational methods, often in combination with wet-laboratory experiments, to investigate biological mechanisms across a broad range of topics.
Cooper Lab Basic Sciences The Cooper Lab investigates proteins involved in the signaling pathways that allow cells to communicate with each other. In particular, they study a protein called Disabled and the Src protein family to better understand how they regulate normal cell behavior and the transformation of normal cells to cancer cells.
CORE Family Studies Public Health Sciences This international registry provides a comprehensive infrastructure for facilitating interdisciplinary studies in the genetic epidemiology of colorectal cancer
Crohn's Allogeneic Transplant Study (CATS) Clinical Research A clinical study for treatment of patients with severe Crohn's Disease, using bone marrow transplantation. This study is being conducted by Dr. George McDonald and teams of doctors and nurses at the University of Washington Medical Center, Seattle Children's Hospital and the Fred Hutchinson Cancer Research Center in Seattle.
defeatHIV, the Delaney Cell and Genome Engineering Initiative Clinical Research, Vaccine and Infectious Disease Led by the Hutchinson Center's Drs. Keith Jerome and Hans-Peter Kiem, the Delaney Cell and Genome Engineering Initiative, also known as defeatHIV, is a consortium of FHCRC and external investigators working together to eradicate HIV. Their research efforts utilize the latest cellular and genetic engineering techniques to develop HIV-resistant cells and to target and incapacitate HIV within the host.
DOVE Study Public Health Sciences The purpose of the DOVE Study is to further our understanding of why some women develop ovarian tumors and others do not. The results of this study will help to improve the health of future generations of women.
Eisenman Lab Basic Sciences The Eisenman Lab studies how cell proliferation, growth, and differentiation are regulated through the actions of transcriptional networks, and how this regulation is undermined during tumor progression. The lab employs the tools of molecular biology as well as mammalian and Drosophila genetics to study basic mechanisms underlying normal and abnormal cellular functions.
Emerman Lab Human Biology, Basic Sciences The Emerman Lab studies the molecular and evolutionary basis for the replication of HIV and related viruses, with an emphasis on the interaction of these viruses with their host cells. Their goal is to understand what determines resistance or vulnerability to current, past and potential viral diseases.
Epidemiology and Biostatistics Training Public Health Sciences Provide skills in epidemiology and biostatistics that will enable the trainee to address this problem through the conduct of high quality cancer research.
Etzioni Lab Public Health Sciences The Etzioni Lab focuses on statistical methods for prostate-cancer studies, with the goal of improving guidelines for screening and treatment. Etzioni has assessed the likely impact of prostate-specific antigen testing on prostate-cancer incidence and mortality, and developed approaches for evaluating new cancer-screening biomarkers.
EXCEL Study Public Health Sciences The ExCel research study is a breast cancer prevention clinical trial. It is an important international clinical trial designed to determine whether a special type of medication can prevent breast cancer in healthy postmenopausal women who are at an increased risk for developing breast cancer.
Fero Lab Clinical Research The Fero Lab studies how cell-cycle regulatory genes, p27 and Rb, control growth of tumors and normal tissues. Using novel mouse models and genomic technologies, they have discovered that cell cycle inhibitors and microRNAs regulate T-cell growth and differentiation, whereas mutations of these genes cooperate in lymphoma development.
Flax FX Study Public Health Sciences Flaxseed and many nuts contain lignans. The "phytochemicals" are thought to be beneficial to health but it is not clear how they work. Help us research how flaxseed lignans affect the colon.
Fong Group Vaccine and Infectious Disease The Fong Group specializes in using biostatics and computer modeling to investigate complex biological problems, with an emphasis on vaccine development. The group��is working together with other Hutchinson Center researchers to evaluate immune responses to HIV vaccines, and to design and analyze HIV vaccine trials.
Galloway Lab Human Biology The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.
Geballe Lab Human Biology The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses.
Genome-Wide Association Study in Early-Onset Breast Cancer Public Health Sciences This study aims to conduct a genome-wide association study of young (less than 50 years) invasive female breast cancer to identify new genes responsible for young cases who are negative for BRCA1 and BRCA2 gene mutations.
Gilbert Group Vaccine and Infectious Disease Statistical design and analysis of HIV vaccine efficacy trials
Gottardo Lab Vaccine and Infectious Disease The Gottardo Lab conducts research in computational biology and statistical genomics with applications to high throughput biological assays and immunology.
Gottschling Lab Basic Sciences The Gottschling Lab uses budding yeast as a model system to investigate fundamental questions in biology. One of their current areas of research interest is the striking link between increasing age and cancer incidence in humans.
Grandori Lab Human Biology The Grandori Lab focuses on exploiting the weaknesses of cancer cells to identify targeted, less toxic cancer therapies. RNA interference (RNAi) combined with high throughput technology enables us to interrogate the human genome for genes that are essential for viability of molecularly defined cancer cells, thus allowing the unbiased identification of these Achilles' heels.
Greenberg Lab Clinical Research The Greenberg Lab's guiding research goals are to understand the principles underlying T cell recognition of viruses and cancer cells, to determine why such responses often fail to eliminate the virus or cancer, and to develop cellular and molecular approaches that manipulate the immune system to treat human viral and malignant diseases.
Hahn Lab Basic Sciences The Hahn Lab studies the mechanism and regulation of transcription, the process of mRNA synthesis. Transcriptional regulation is one of the key steps controlling cell growth, differentiation and development, and defects cause many human illnesses. Using biochemistry, structural biology and molecular genetics, the lab focuses on the mechanism of the large conserved protein complexes that regulate and promote transcription.
Hansen Lab Clinical Research The Hansen Lab's primary research focus is graft-vs.-host disease (GVHD). Ongoing studies investigate whether monitoring of gene expression correlates with T-cell activation, programmed cell death, severity of GVHD, the patient���s response to primary therapy or treatment failure, and emergence of tolerance.
Health Effects of Sugar-Sweetened Beverages Study Public Health Sciences Fred Hutchinson Cancer Research Center is recruiting adults 18-65 years old to participate in a study that will investigate the health effects of sugar-sweetened beverages.
Heimfeld Lab Clinical Research The Heimfeld Lab focuses on the translation of new cell-based therapies from the scientist's bench to the patient's bedside. Areas of research include improvements in specific cell-subset selection, large-scale therapeutic-cell culturing in closed systems, optimized cryopreservation and cell storage.
Henikoff Lab Basic Sciences The Henikoff Lab studies the structure, function and evolution of chromosomes. They also develop tools for epigenomics and functional genomics.
Hockenbery Lab Clinical Research The Hockenbery lab studies programmed cell death (apoptosis) pathways that are defective in many cancer cells; and the role of cancer-cell metabolism in apoptosis, oncogene functions, and environmental/dietary risk factors, including excess supply of nutrients. After identifying cancer-selective targets, they carry out small-molecule screens for inhibitors to identify lead compounds as anticancer agents.
Holland Lab Human Biology The Holland lab works at the intersection of multiple disciplines to address the molecular basis of brain tumors and develop new approaches to their treatment. Our research focuses on developing mouse models of brain cancer that mimic the behavior of the disease in patients. Our work with mouse models has led to clinical trials in glioma patients. We also have developed imaging strategies to follow mouse brain tumors as they develop—a powerful system that is used to test promising new drugs with potential benefit for patients.
Huang Lab Vaccine and Infectious Disease The Huang Lab focuses on the evaluation of biomarkers for disease prevention and control. The lab also studies genetic epidemiology, particularly the detection of gene-environment interactions based on genome-wide association studies and the construction of risk prediction models using the genetic regulatory network.
INSIGHT Study Public Health Sciences The purpose of this study is to look for the possible causes of developing a second breast cancer among women who had an in situ breast cancer.
Institute for Prostate Cancer Research Clinical Research The institute is a collaborative effort of Fred Hutchinson Cancer Research Center and UW Medicine. A natural outgrowth of established research and clinical collaborations, the IPCR brings together a world-renowned team whose mission is to understand the causes of prostate cancer and its progression, develop new prevention strategies, devise innovative diagnostics and improve survival and quality of life.
IRIS Study Public Health Sciences The goal of the IRIS study is to enroll about 1,000 women with certain gynecologic conditions to share their medical history and provide a saliva sample, which contains genetic material. We want to better understand what medical, lifestyle, background, and genetic factors may be related to these conditions.
Jerome Lab Vaccine and Infectious Disease Chronic and latent phases of virus infections, virus immune evasion mechanisms, and potential curative therapeutic approaches to these infections.
Kemp Lab Human Biology The Kemp Lab studies tumor formation in mice to better understand how environmental and genetic factors interact to cause cancer. They also work to develop simple blood tests for early cancer detection by discovering biomarkers, the proteins that signal the earliest traces of disease.
Kiem Lab Clinical Research The Kiem Lab studies stem cell biology and stem cell gene transfer with the goal of developing new treatment strategies for patients with genetic and infectious diseases and cancers.
Lampe, P Lab Public Health Sciences The Paul Lampe Lab attempts to discover early detection cancer biomarkers and investigates the control of cell growth at the cell biology level. Of particular interest is the role that gap junctions play in the regulation of cell growth and the cell cycle, and the disruption of this relationship during cancer development.
Li Lab Public Health Sciences Dr. Li uses a multidisciplinary approach to understand factors related to the causes and patient outcomes of breast cancer. Current projects include identifying new biomarkers that could be used for early detection, evaluating risk factors for different types of breast cancer, determining predictors of poor outcomes among breast cancer survivors, and assessing disparities in cancer stage, treatment and survival by race/ethnicity.
MacPherson Lab Human Biology The MacPherson Lab is focused on understanding the mechanisms through which cancer-mutated genes drive tumorigenesis. The lab studies two tumor types, small cell lung carcinoma (SCLC) and retinoblastoma. Genomic analyses of human tumors allow us to identify gene mutations that may contribute to tumor initiation, progression and metastasis.
Madeleine Lab Public Health Sciences Dr. Madeleine's research focuses primarily on the molecular epidemiology of disease-causing agents, or pathogens, and the immune response to them that may be associated with cancer development and prognosis. Another interest is the role of chronic, undiagnosed immune system dysfunctions (such as those occurring with age, obesity, physical inactivity, hormone use, and UV exposure) in cancer development.
Malik Lab Basic Sciences The Malik Lab hunts for rapidly evolving proteins in order to understand how conflicts between genes affect human evolution. Such genetic conflicts can arise between virus and host genes as each fights for survival, but they can affect the function of essential genes, including those implicated in cancer.
Markers of B-Cell Stimulation as Potential Predictors of Non-Hodgkin Lymphoma Public Health Sciences We are conducting a nested case-control study of biologic markers of a B-cell stimulatory host environment as predictors of B-cell NHL among 500 cases and 500 pair-matched controls from the WHI Observational Study (OS), among whom biologic samples were collected an average of 10 years before NHL diagnosis.
McElrath Lab Vaccine and Infectious Disease The McElrath Lab is dedicated to understanding the human immune response mechanisms in HIV infection and resistance in a way that can be translated into the development of an effective HIV vaccine.
McGregor Lab Public Health Sciences The McGregor Lab leads the Stress Management and Relaxation Training, or SMART, studies, which focus on understanding the effects of stress management on behavioral and biological factors that are relevant to cancer development, such as diet, exercise, immune function, DNA repair and cellular aging processes.
McIntosh Lab Public Health Sciences The McIntosh Lab develops primarily computational approaches for studying proteins and genomes in cancer. Their primary goal is to discover and evaluate diagnostic and early-detection biomarkers in serum, with research projects in ovarian, breast and pancreatic cancer and neurodegenerative diseases.
Moens Lab Basic Sciences The Moens Lab uses zebrafish as a model system to study how genes control the early development of the brain in vertebrates. Their work adds to our understanding of the causes of cancer because many of the genes that control embryonic development are the same ones that are wrongly regulated in cancer cells.
Molecular Change and Thyroid Cancer Risk After Chernobyl Public Health Sciences This study will investigate the occurrence and molecular characteristics of thyroid cancer in residents of the Bryansk Oblast of the Russian Federation who were up to 50 years of age at the time of exposure to radiation from the Chernobyl Power Station accident on April 26, 1986.
Molecular Epidemiology Lab Public Health Sciences The Molecular Epidemiology Lab provides investigators working on population-based studies with laboratory-based research expertise through a collaborative scientific relationship. The lab is headed by Dr. Karen W. Makar in the Cancer Prevention Program and supports epidemiological and clinical investigators at FHCRC and their collaborators at other institutions.
Molecular Epidemiology of Endometrial Cancer Public Health Sciences This study tests the hypotheses that the risk of developing endometrial cancer is related to variation in genes that encode for enzymes: 1) involved in the biosynthesis or catabolism of estrogens, or in the response to steroid hormones, and 2) that repair DNA damage generated during estrogen exposure.
Molecular Epidemiology of Lung Cancer Public Health Sciences A study determining whether polymorphisms of enzymes involved in the repair of smoking-induced DNA damage, namely those from the base excision (BER) and nucleotide excision repair (NER) pathways, are associated with risk of lung cancer.
Mueller Lab Public Health Sciences Dr. Mueller's research focuses on the roles of maternal, gestational, early life factors, and early environmental exposures in the occurrence of childhood cancer and autoimmune diseases. She also studies reproductive history in relation to cancer and cancer survival in women, and reproductive outcomes among male and female childhood cancer survivors.
Nelson Lab Clinical Research The J. Lee Nelson Lab studies microchimerism, a natural state in which cells are exchanged between mother and fetus during pregnancy and can remain in the other individual decades later. They study the role of this phenomenon in autoimmune diseases, pregnancy complications and cancer, as well as its impact on the success of blood stem-cell and organ transplants.
Night Shift Workers and Hormone Levels in Men Public Health Sciences This study will be the first effort to assess the effects of night shift work on melatonin and the hormones of most interest in the etiology of prostate cancer.
Nutrition and Physical Activity Assessment Public Health Sciences This project focuses on the use of biomarkers to evaluate and compare measurement properties of prominent nutritional and physical activity assessment methods, and on the use of biomarker-calibrated nutrient consumption and activity-related energy expenditure estimates in disease association studies in the Women’s Health Initiative (WHI) cohorts of postmenopausal women.
Olsen Lab Basic Sciences The Olsen Lab uses a combination of lipid biochemistry and genetics to study membrane maintenance in the nematode, C. elegans. Cellular membranes are affected in many diseases and in natural aging, and our main goal is to define genes that are important for preserving proper membrane composition and function.
Olson Lab Clinical Research The Olson Lab studies pediatric brain tumors, brain development and neurodegenerative disorders. The lab has a strong focus on emergent technologies such as "tumor paint," which causes cancer cells to glow with light so that surgeons can see them during an operation.
Oral Cancer: Molecular Profiles & Clinical Outcomes Public Health Sciences Our goals in this study are to determine whether: 1) The prognosis of OSCC patients is associated with tumor gene expression profiles; 2) OSCC tumor characteristics known to be related to patient outcome - such as stage and nodal status - are associated with tumor gene expression profiles; and 3) Tumor gene expression differs among invasive OSCC, pre-neoplastic oral squamous cell lesions, and normal oral tissue.
Overbaugh Lab Human Biology The Overbaugh lab has a long-standing interest in understanding the mechanisms of HIV-1 transmission and pathogenesis. The lab is part of a larger team, comprising researchers in both Seattle and Kenya (The Nairobi HIV/STD Project). Trainees in the lab have opportunities to engage in studies of viral evolution, virus-host cell interactions, and viral immunology all within the context of international collaboration.
Paddison Lab Human Biology The Paddison Lab uses functional genetics to probe the underlying biology of mammalian stem/progenitor cells. We identify and characterize gene products affecting stem cell self-renewal, differentiation, proliferation, or survival through the use of RNAi knockdown technologies.
Pagel Lab Clinical Research The Pagel lab focuses on the development and improvement of antibody therapies for leukemia and lymphoma, with the goal of decreasing toxic side effects while increasing the treatment's effectiveness. Our projects focus on advancing radioimmunotherapy through a pre-targeted method of delivering radiation to tumor sites.
Parkhurst Lab Basic Sciences The Parkhurst Lab studies how genes get turned on and off as fruit-fly embryos develop and how errors in this process can lead to cancer and other diseases. They also investigate wound healing and complex signals involving proteins that can affect a cell's "skeletal" structure.
Partnership for the Advancement of Cancer Research Project Public Health Sciences The National Cancer Institute (NCI) has awarded funds to enhance and expand an existing collaboration between New Mexico State University (NMSU) and the Fred Hutchinson Cancer Research Center (FHCRC). This collaboration is designed to enhance the opportunities of minorities and underrepresented individuals, including Hispanics and Native Americans, to become trained and experienced in cancer research.
Paulovich Lab Clinical Research The Paulovich Lab works to characterize human variation and to relate this variation to clinically relevant endpoints, such as predicting a patient's risk of cancer and tolerance for treatments. Projects range from studying cellular DNA damage response in yeast and mammalian cells, to developing novel mass spectrometry-based technologies for finding and validating new protein biomarkers to serve as diagnostic tests.
Peichel Lab Human Biology The Peichel Lab uses a small fish called the threespine stickleback as a model organism to conduct research aimed at identifying the genetic and molecular mechanisms that underlie evolutionary processes. Research topics include understanding evolution of the fish's behavior and sex chromosomes.
Pepe Lab Public Health Sciences The Pepe Lab develops guidelines and software to promote the use of sound statistical methods by scientists who are working to evaluate diagnostic or prognostic medical devices and biomarkers.
Peter Nelson Lab Human Biology Dr. Peter Nelson's lab focuses on understanding the molecular, cellular and physiological events that lead to cancer initiation and progression. A particular emphasis involves hormonal carcinogenesis and prostate cancer with the goal of developing new strategies for diagnosis, prognosis and therapy.
Peters Studies Public Health Sciences Peter's Lab research is focused on the genetic and molecular epidemiology of common complex diseases, including cancer, obesity, type 2 diabetes, and cardiovascular diseases, as well as intermediate traits, including inflammation and metabolic measurements. Within well characterized and diverse study populations, we are studying the impact of common and rare genetic variants across the entire genome, as well as interactions between genetic variants and environmental factors (such as diet, exercise, smoking and aspirin use).
Pharmacogenetics of the Folate Pathway Public Health Sciences A study to investigate polymorphisms in proteins important for folate metabolism and their effect on the toxicity and effectiveness of methotrexate, a drug widely used in cancer chemotherapy
Polymorphisms in PG/COX Pathway and Colorectal Polyps Public Health Sciences The goal of this study is to evaluate the association between common genetic changes in enzymes, growth factors, and receptors linked to prostaglandin synthesis or COX activity and the risk of precancerous colon polyps
Porter Lab Human Biology The Porter Lab focuses on identifying and understanding the molecular events in normal and cancer cells that are associated with the initiation and progression of human cancer, with a focus on breast and ano-genital cancers. They also investigate the molecular profiles that distinguish different types of cancer or determine an individual's cancer risk.
POWDER Study Fred Hutch researchers are working to understand the challenges women with disabilities face when pregnant and birth outcomes among women with chronic conditions that may restrict mobility or care access.
Press Lab Clinical Research Dr. Press is a pioneer in immunotherapy, a treatment strategy that harnesses the power of the immune system. His lab engineers antibodies that help to destroy cells involved in blood cancers and carry radiation directly to cancer cells. They also genetically modify disease-fighting T-cells to boost their ability to recognize and kill lymphoma cells.
Priess Lab Basic Sciences The Priess lab studies how cells coordinate their shape and fate during the development of complex tissues and organs. Most of these studies use the nematode C. elegans as a model organism.
Prlic Lab Vaccine and Infectious Disease The Prlic Lab primarily focuses on two populations of the adaptive immune system: CD8 T cells and NK cells. The lab studies these cells in a variety of different in vivo (mouse) and in vitro model systems to gain mechanistic insight and learn how to manipulate these cells for therapeutic purposes.
Program in Prostate Cancer Research Public Health Sciences The Program in Prostate Cancer Research at Fred Hutchinson Cancer Research Center is a multidisciplinary program. The aim is to foster interactive communication and the development of new or expanded research projects between investigators with diverse expertise and interest in prostate cancer.
Protein Biomarkers of Cancer Risk in Older Persons Public Health Sciences Using a case-cohort study design, this study evaluates if baseline plasma proteomic patterns can be used to distinguish between subjects who will and will not develop breast, colorectal, lung, and prostate cancers.
Protein Biomarkers of Cancer Risk in Older Persons Public Health Sciences Study evaluates if baseline plasma proteomic patterns can be used to distinguish between subjects who will and will not develop breast, colorectal, lung, and prostate cancers. In addition, it evaluates if the addition of known risk factors for these cancers.
Puget Sound Oncology Consortium Clinical Research Secure member site for the Puget Sound Oncology Consortium (PSOC) - a non-profit corporation located at the Fred Hutchinson Cancer Research Center. Physicians in the Puget Sound area established PSOC in 1983 to conduct and promote clinical trials.
Quilt Study Public Health Sciences The Quilt Study is a study of predictors of disease progression and recurrence in women diagnosed with breast cancer at ages 45-79 to identify pre- and post-diagnosis exposures and events that may increase the risk of recurrence; assess pre-diagnosis exposures for their association with tumor characteristics and risk of recurrence; and
evaluate how tumor markers, both ones currently used in clinical care and novel ones not currently in use, relate to breast cancer progression or recurrence across age groups.
Radiation and Environmental Exposure Studies Public Health Sciences The REES group focuses on identifying risk factors and causes of cancer and other diseases associated with many types of environmental exposures, including radiation, persistent organic pollutants, electromagnetic fields, and factors that disrupt normal circadian rhythm. Projects have focused on breast cancer, thyroid cancer and other thyroid diseases, lymphomas, and myelodysplastic syndrome.
Radich Lab Clinical Research The Radich Lab studies the molecular genetics of response, progression and relapse in human leukemia. Research topics include the detection of minimal residual disease, the role of signal transduction abnormalities in leukemia, and the construction of gene-expression profiles of response and progression.
Randolph Lab Public Health Sciences The Randolph Program's research focuses on mathematical and statistical methods for high-dimensional, functional and otherwise "non-standard" data including: image-based data, mass spectrometry, various spectroscopies, microbiome and genetic arrays as well as longitudinal data. Projects and collaborations involve studies for discovery and validation of molecular properties and markers of disease.
REACH Group Public Health Sciences Dr. Ramsey directs the Research and Economic Assessment in Cancer and Healthcare (REACH) group, which focuses on cutting-edge cost-effectiveness and outcomes research in cancer prevention and treatment. REACH also has experience in designing and performing cost-effectiveness analyses of drugs, devices and interventions, with an eye towards supporting public and private decision making to maximize health value under resource constraints.
REACH Study Public Health Sciences The purpose of the REACH Study is to further our understanding of why some young women develop breast cancer and others do not. Studies like the REACH Study compare information from people who have a particular disease to those who do not.
REDA Study - The Reproducibility of EDA Public Health Sciences Research suggests that estrogen (EDA) levels may be useful to assess a woman's risk of breast cancer, although it is yet unclear which forms of estrogens provide the most information. The goal of this study is to find out if they vary over time or stay at constant levels in healthy women.
Reid Lab Human Biology The Reid Lab is focused on understanding the mechanisms by which environmental exposures (i.e. aspirin or other nonsteroidal antiinflammatory agents) affect the evolution of clones that lead to the development of esophageal adenocarcinoma in patients with Barrett's esophagus.
Research Cell Bank Clinical Research The Research Cell Bank (RCB) is a qualified, experienced research facility that has been actively engaged in clinical research through B-lymphoblastoid cell (B-LCL) transformation and maintenance, DNA extraction, and inventory control for more than 30 years. The RCB is currently expanding its role as a core repository of reagents and services to better serve the needs of investigators worldwide.
Risk Factors for Second Primary Breast Cancer Among DCIS Survivors Public Health Sciences The study of epidemiological factors, clinical and pathological characteristics, and tumor marker expression influence the risk of second primary invasive contralateral breast cancer among survivors of a first primary invasive breast cancer.
Roberts Lab Basic Sciences The Roberts Lab has discovered key proteins that regulate cell division and explored how changes in cell-cycle proteins may inform the treatment of specific cancers. Current research focuses on the development of mouse models of human cancers.
Roth Lab Basic Sciences The Roth Lab studies suspended animation and metabolic hibernation as a means to temporarily halt, or "dial down," metabolism. One day such techniques may help to buy time for critically ill patients on organ-transplant lists and in trauma situations.
Salama Lab Human Biology The Salama lab studies the gastric bacterial pathogen Helicobacter pylori, which infects half the world's population and can cause ulcers and gastric cancer.
Schiffer Group Vaccine and Infectious Disease The Schiffer Group aims to gain a better understanding of the quantitative features of human pathogens and immune responses. In close collaboration with colleagues at the Fred Hutchinson Cancer Research Center and the University of Washington, the Group designs mathematical models that capture growth and decay kinetics of infectious organisms. These models attempt to replicate detailed empirical datasets, and in turn are used to inform subsequent human studies and laboratory experiments.
SCOT Study Public Health Sciences The SCOT Study was funded by the National Institutes of Health and directed by Dr. Madeleine at the Fred Hutchinson Cancer Research Center and co-investigators at local transplant institutions, including the University of Washington, Virginia Mason and Swedish Medical Centers. We are analyzing the study data to learn more about factors like genetics or viruses that may be involved in why many transplant patients develop skin cancer after transplant.
Seattle 5 a Day Worksite Program: Eat 5 for Life Public Health Sciences A randomized trial to evaluate the effectiveness of an intervention to maintain change in companies that have already received an intervention to increase fruit and vegetable consumption
Seattle Barrett's Esophagus Research Program The Seattle Barrett's Esophagus Research Program is committed to understanding the genetic mechanisms and environmental risk factors that ultimately result in cancer of the esophagus, and identifying intermediate genetic markers that will allow for the early identification of patients at an increased risk of developing esophageal cancer so that the cancer can be prevented or detected when it is early and the patient can be cured.
SHARE Study Public Health Sciences The focus of the SHARE Study is to determine risk factors specific to three different types of breast cancer. Studies like this one compare information from people who have a particular disease to those who do not. This type of research allows us to identify what specific characteristics of exposures may cause different types of breast cancer.
Shimamura Lab Clinical Research The Shimamura Lab works to understand the molecular mechanisms contributing to development of blood cells (hematopoiesis) and cancer (tumorigenesis), with the ultimate goal of informing rationally designed therapeutic strategies. Their research focuses particularly on genetic marrow failure syndromes.
Shou Lab Basic Sciences The Shou Lab uses experimental biology, mathematics and engineering to study a variety of biological problems. Research interests include how cooperative systems evolve despite threats from "cheaters" that consume benefits without paying a fair cost, and how cells cope with nutrient limitations.
Simon Lab Clinical Research The Simon Lab works toward identifying new anticancer drugs through a wide range of experimental techniques and systems, ranging from organic synthesis to genetic screens.
Smith Lab Basic Sciences The Smith Lab works to understand how genetic recombination and DNA repair are accomplished, and how they are regulated to occur at the proper place and time. As deviations in this process can result in birth defects and cancers, this work may lend insight into the causes of these diseases and ways of predicting or preventing them.
Spies Lab Clinical Research The Spies Lab focuses on experimental studies of the human NKG2D lymphocyte receptor and its ligands, and the mechanisms whereby these proteins stimulate or suppress immune responses against cancer and in autoimmune disease.
Stoddard Lab Basic Sciences The Stoddard Lab studies the structure and mechanism of enzymes, the body's catalysts of biological reactions, in order to harness them for use in biotechnology and medicine. The engineering and redesign of certain enzymes could be used in targeted therapies for genetic diseases such as hemophilia and cystic fibrosis.
Storb Lab Clinical Research Transplantation Biology combines basic and translational research directed at understanding and eliminating major barriers to successful allogeneic hematopoietic stem cell transplantation; these include host-versus-graft reactions, graft failure, acute and chronic graft-versus-host disease (GVHD), regimen-related toxicities, and induction of graft-versus-tumor reactions. The program’s goal has been to use stem cell transplantation to treat patients with malignant and nonmalignant hematologic diseases.
Strong Lab Basic Sciences The Strong Lab analyzes the structure of proteins and protein-receptor complexes that control the immune system's response to disease. Building on the principles learned from these studies, they also participate in a collaborative project to design proteins for a vaccine to prevent AIDS.
Survivorship Program Clinical Research Fred Hutchinson Cancer Research Center's Survivorship Program offers support, treatment and education to cancer survivors.
A member of the LIVESTRONG Survivorship Center of Excellence Network, the Survivorship Program is helping to lead a nationwide effort to help survivors and their healthcare providers understand, prevent and manage the medical and psychosocial effects of having cancer and receiving treatment.
Taniguchi Lab Human Biology The Taniguchi Lab's long-term research objective is to elucidate molecular mechanism of DNA damage response pathways, such as the Fanconi Anemia-BRCA (FA-BRCA) pathway, and their involvement in carcinogenesis.
Tapscott Lab Human Biology The Tapscott Lab studies gene transcription and expression in normal development and disease, with an additional emphasis on rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other research areas include gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.
Tewari Lab Human Biology The Tewari Lab draws on perspectives from systems biology and complexity science to address important problems in basic and applied cancer research. More specifically, the lab is investigating microRNAs, which are 22 nt non-protein-encoding RNA molecules that function to repress messenger RNA targets to modulate gene expression networks.
Thompson Studies Public Health Sciences Led by Dr. Beti Thompson, this research group works to understand why disparities in cancer incidence and survival rates exist among different populations, especially Latinos. The group also supports efforts to reduce other health disparities, including diabetes and pesticide exposure, in minority communities in the United States and abroad.
Tobacco & Health Behavior Science Research Group Public Health Sciences This group, led by Dr. Jonathan Bricker, focuses on two key questions: (1) Can innovative theory-based behavioral interventions succeed in changing unhealthy behaviors (e.g., smoking)?; (2) Why do people engage in unhealthy behaviors (e.g., smoking)?
Transmission of Stomach Bacteria Study Human Biology Fred Hutchinson Cancer Research Center is recruiting families to participate in a study about the transmission of Helicobacter pylori, a stomach bacteria infecting half of the world's population. The bacteria can cause ulcers and stomach cancer.
Tsukiyama Lab Basic Sciences The Tsukiyama Lab studies chromatin, the complex of DNA and proteins that make up our chromosomes, and how chromatin structure controls essential processes that take place on DNA.
Ulrich Lab Public Health Sciences The Ulrich Group conducts research related to cancer prevention, prognosis and survivorship, with an emphasis on colorectal cancer. Topics of study include the effects of folate, vitamin D, exercise, diet and genetics on cancer risk, prognosis and treatment outcomes, and biological markers of cancer risk.
Use of Exogenous Progestins and Risk of in situ and Invasive Breast Cancer Public Health Sciences The first project investigates the relationship between use of depo-medroxyprogesterone acetate on risk of in situ breast cancer among premenopausal women 20-44 years of age. The second study is a population-based case-control study evaluating the relationship between use of progestin containing hormone therapy regimens and risk of invasive pure lobular, ductal/lobular, and ductal carcinomas among postmenopausal women 55-74 years of age.
Vasioukhin Lab Human Biology The Vasioukhin lab studies the mechanisms and significance of cell polarity and cell adhesion in normal mammalian development and cancer. In addition, we have a significant interest in the mechanisms responsible for initiation and progression of human prostate cancer. We believe that it is important to study cells in their normal microenvironment.
Vitamin D, Diet and Activity Study Public Health Sciences The Vitamin D, Diet and Activity (ViDA) Study is being conducted to determine whether Vitamin D can help decrease breast cancer risk by reducing body fat or decreasing weight gain.
Walter Lab Clinical Research Research is focused on clinical trials testing new drugs and drug combinations to treat acute myeloid leukemia.
Wang Program Public Health Sciences The Wang Lab focuses on developing statistical and computational methods to address scientific questions based on data from high throughput biology/genetics experiments. The ultimate goal is to enhance our understanding of cell activities and disease initiation/progression to a system level by integrating information from diverse biological sources (genetics/genomics, proteomics, and phenotypes).
Warren Lab Clinical Research The Warren Lab studies human antitumor immune responses at the cellular and molecular level in order to learn how these immune responses can be exploited to treat human cancer.
Women's Health Initiative Public Health Sciences The Women’s Health Initiative (WHI) is a major, long-term research program designed to address cardiovascular disease, cancer and osteoporosis – the most frequent causes of death, disability and poor quality of life in postmenopausal women. Fred Hutch is home to the study's coordinating hub, led by Dr. Garnet Anderson and colleagues Drs. Ross Prentice, Andrea LaCroix, and Charles Kooperberg
Youth & Adult Smoking Research Public Health Sciences Youth and Adult Smoking Research works to learn more about attitudes and practices about smoking and non-smoking in teens. To learn how they change from their teen years to their young adult years. And to develop and test interventions for smoking prevention and smoking cessation, to see if they can help teens avoid and/or quit smoking.
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The Hutchinson Center's clinical research breakthroughs are delivered to patients through our treatment arm, the Seattle Cancer Care Alliance. This collaboration combines the strengths of the Hutchinson Center, UW Medicine and Seattle Children's.
Fred Hutchinson Cancer Research Center is a world-renowned nonprofit research organization working to improve the prevention, detection and treatment of cancer and related diseases. We are proud to be home to three Nobel laureates.